Navigation Links
TRUST study data confirms safety and efficacy of erlotinib for advanced lung cancer
Date:9/30/2010

Featured in the October edition of the Journal of Thoracic Oncology (JTO), data from The Tarceva Lung Cancer Survival Treatment (TRUST) confirms the safety and efficacy profile of erlotinib, a highly potent oral active, reversible inhibitor of epidermal growth factor receptor (EGFR) tyrosine-kinase (TK) activity in a large heterogeneous non-small cell lung cancer (NSCLC) population.

Erlotinib has been shown to significantly increase survival for patients with previously treated advanced NSCLC. Certain groups of patients with NSCLC, such as those with a particular type of cancer - adenocarcinoma , women, Asian ethnicity and non (minimal) smokers are reported to be more likely to have tumor responses to EGFR TK inhibitors (TKIs) than other groups. However, results from the TRUST study suggest that erlotinib can benefit a wide range of patients, including those who have previously been thought unlikely to benefit from this treatment.

The large, global, open-labeled, phase IV trial TRUST study included the participation of 513 centers across 51 countries, culminating safety data from more than 6,500 patients. In patients with advanced NSCLC, the progression-free survival and overall survival in this study were 3.25 months and 7.9 months, respectively, and the disease control rate (defined as the sum complete response, partial response, or stable disease) was 69 percent.

As a post marketing surveillance trial (phase IV) occurring after erlotinib received permission to be sold, the study provided an opportunity to evaluate the efficacy and safety of this medication in a broad patient population in a real-life clinical setting. Furthermore, it included patients with advanced stage IIIB/IV NSCLC who had previously failed on or were considered unsuitable to receive standard chemotherapy or radiotherapy and were ineligible for other erlotinib trials.

"The criteria used for selecting the most appropriate therapy for a patient
'/>"/>

Contact: Kaitlin Doody
kdoody@spectrumscience.com
202-587-2553
International Association for the Study of Lung Cancer
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Medibank Health Solutions: The New Name to Trust in Workplace Health
2. BioMed Realty Trust Reports Fourth Quarter and Full-Year 2009 Financial Results
3. Three NHS Trusts Choose BigHand Voice Technology Under YHCPC Framework Agreement
4. BestMassage.com Receives Award for Customer Trust
5. BioMed Realty Trust Promotes Matthew G. McDevitt to Executive Vice President, Real Estate
6. Healthcare Trust of America, Inc. Executes Agreement to Acquire an Approximately 260,500 Square Foot Medical Office Portfolio in Indiana
7. Healthcare Realty Trust Announces Fourth Quarter Results
8. PIA Hails Removal of Medical Malpractice Insurers From Bill Restricting Insurance Antitrust Exemption
9. Universal Health Realty Income Trust Reports 2009 Fourth Quarter and Full Year Financial Results
10. Pelosi, Senior Democrats Remarks at News Conference on Repealing Health Insurance Industry Anti-Trust Exemption
11. Healthcare Trust of America, Inc. Executes Agreement to Acquire an Approximately 60,300 Square Foot Medical Office Building in Sugar Land, Texas
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2014)... Boca Raton, FL (PRWEB) September 02, 2014 ... online audience targeting and multi-channel email marketing is pleased ... to the market, Firearms & Freedom as ... these online properties represent more than one million concerned ... and display advertising. , “We are honored to ...
(Date:9/2/2014)... patient adherence to treatment following a myocardial infarction ... results reported at the European Society of Cardiology,s ... Principal Investigator Valentin Fuster, MD, PhD, Director of ... at Mount Sinai and General Director of the ... in Madrid, Spain, the novel fixed-dose combination drug ...
(Date:9/2/2014)... of California, San Diego School of Medicine have identified ... The findings, reported in the current issue of ... cancer mortality worldwide. An estimated 40,000 women in America ... the American Cancer Society. , "The take-home message of ... to target breast cancer metastasis through a pathway regulated ...
(Date:9/2/2014)... associated with many health risks, including heart disease and ... possible way to mitigate one often-overlooked risk: not buckling ... by Sheldon H. Jacobson, a professor of computer science ... are associated with a decrease in seatbelt usage. However, ... in effect. , "Primary seatbelt laws lead to increased ...
(Date:9/2/2014)... 02, 2014 To commemorate the 13th ... children’s literacy organization that has donated more than 200,000 ... founding in 2001, will host the 5th Annual BJF ... p.m. at Barnes & Noble Tribeca. Featuring special guest ... public event for children and families will celebrate the ...
Breaking Medicine News(10 mins):Health News:ASG Continues to Bring New Lists to Market 2Health News:ASG Continues to Bring New Lists to Market 3Health News:New polypill increases heart attack patients' medication adherence 2Health News:New polypill increases heart attack patients' medication adherence 3Health News:Enzyme controlling metastasis of breast cancer identified 2Health News:Seatbelt laws encourage obese drivers to buckle up 2Health News:Brooke Jackman Foundation Hosts 5th Annual Read-A-Thon, A Celebration of Hope and Literacy in New York City to Commemorate 13th Anniversary of 9/11 2Health News:Brooke Jackman Foundation Hosts 5th Annual Read-A-Thon, A Celebration of Hope and Literacy in New York City to Commemorate 13th Anniversary of 9/11 3
... , TUESDAY, Sept. 27 (HealthDay News) -- Men may need ... suggests. The study found that men were far more ... adenomas) in their colon -- 24.9 percent of men compared ... at an earlier age. "In our study, analysis of ...
... Discussing and documenting patients, preferences for care at the end ... recent claims. A new study published today in the ... with their physicians about end-of-life care and have an advance ... patients who do not have these discussions and documents. ...
... Steven Reinberg HealthDay Reporter , TUESDAY, Sept. 27 ... to an enlarged prostate, saw palmetto extract doesn,t seem to ... at high doses, a new study finds. Many men ... relieve lower urinary tract symptoms related to benign prostatic hyperplasia ...
... been honored with the Presidential Early Career Award ... and scientific leadership. It is the highest honor ... engineering professionals in the early stages of their ... Sept. 26. Justin Kasper, an astrophysicist at ...
... TUESDAY, Sept. 27 (HealthDay News) -- Average annual premiums for ... past year, to more than $15,000, according to new research ... Educational Trust. On average, U.S. workers now pay more ... has far outpaced growth in workers, wages, the 2011 employer ...
... an associate professor in the department of mathematical ... Arts, has received the honor of "Excellence in ... Convocation at NJIT traditionally honors select faculty ... level of excellence over a sustained period. ...
Cached Medicine News:Health News:Do Men Need Colon Cancer Screening Earlier Than Women Do? 2Health News:Do Men Need Colon Cancer Screening Earlier Than Women Do? 3Health News:Saw Palmetto Doesn't Help Enlarged Prostate: Study 2Health News:Saw Palmetto Doesn't Help Enlarged Prostate: Study 3Health News:President Barack Obama recognizes outstanding scientists at the Smithsonian 2Health News:Cost of U.S. Workers' Health Premiums Surged in 2011 2Health News:Cost of U.S. Workers' Health Premiums Surged in 2011 3Health News:Gifted mathematician honored at NJIT convocation 2
(Date:9/2/2014)... 2, 2014  EMD Serono, Inc., a subsidiary of ... today that Drew Young has joined the ... this capacity, he will be responsible for leading the ... including future products.   Bringing more than 20 ... sales efforts at pharmaceutical and biotech companies, Mr. Young ...
(Date:9/2/2014)... 2014  Cyberonics, Inc. (NASDAQ: CYBX ... study.  Results of the study presented by a ... cardiology congress and concurrently published by the ... Therapy (ART) in patients with moderate to severe ... safe, improves the heart,s ability to pump blood, ...
(Date:9/2/2014)... , Sept. 2, 2014 ResMed (NYSE: ... 150 devices in the United States ... portable, lightweight, and user-friendly life support ventilators. ... mobility and ease of use for patients suffering from ... adult and childhood respiratory disorders. The U.S. launch comes ...
Breaking Medicine Technology:EMD Serono Appoints Drew Young to Senior Vice President, Neurology and Immunology 2EMD Serono Appoints Drew Young to Senior Vice President, Neurology and Immunology 3EMD Serono Appoints Drew Young to Senior Vice President, Neurology and Immunology 4ANTHEM-HF Shows Autonomic Regulation Therapy Is Safe And Improves Heart Function In Patients With Chronic Heart Failure 2ANTHEM-HF Shows Autonomic Regulation Therapy Is Safe And Improves Heart Function In Patients With Chronic Heart Failure 3ANTHEM-HF Shows Autonomic Regulation Therapy Is Safe And Improves Heart Function In Patients With Chronic Heart Failure 4ANTHEM-HF Shows Autonomic Regulation Therapy Is Safe And Improves Heart Function In Patients With Chronic Heart Failure 5ResMed's Revolutionary Life Support Ventilation Platform -- Astral 100 and 150 Devices Now Available in the U.S. 2ResMed's Revolutionary Life Support Ventilation Platform -- Astral 100 and 150 Devices Now Available in the U.S. 3
... Formation in ... Animals, Hearts, SUNRISE, ... of myoblasts modified to express,stromal derived factor-1(alpha) protein (SDF-1) into the ... were recently,presented at two scientific meetings -- the International Society for,Magnetic ...
... Enrollment Program Speeds Oncology Patient Accrual, ... Research Management,Organization (RMO), has contracted with five ... management services for their,clinical trials using the ... the following disease indications: follicular Non-Hodgkin,s,Lymphoma, Metastatic ...
Cached Medicine Technology:Bioheart Reports Promising Results From SDF-1 Modified MyoCell(R) Therapy in Heart Failure Study 2Bioheart Reports Promising Results From SDF-1 Modified MyoCell(R) Therapy in Heart Failure Study 3Bioheart Reports Promising Results From SDF-1 Modified MyoCell(R) Therapy in Heart Failure Study 4Bioheart Reports Promising Results From SDF-1 Modified MyoCell(R) Therapy in Heart Failure Study 5Bioheart Reports Promising Results From SDF-1 Modified MyoCell(R) Therapy in Heart Failure Study 6Pharmatech, Inc. Contracts for Five New Just-in-Time Clinical Trials 2
... DXC-990 camera is a 3 chip 1/2 inch color ... and a high s/n ratio. It offers picture contrast ... and knee control. The user can choose automatic exposure ... The Sony DXC-990 camera is a bayonet mount and ...
Sony DSR-20MD is the right choice If you need digital recording capability. It accepts both s-video and composite inputs....
... image management. Mediscan is an advanced ... derived from extensive experience with clinicians. ... organize, and distribute high quality images, ... effort. Can be connected to flexible ...
For continuous intracranial monitoring of pressure, oxygen and temperature of the brain...
Medicine Products: