Navigation Links
TNF-alpha antagonist stops inflammation-induced colon cancer in its tracks
Date:1/24/2008

Individuals with the inflammatory bowel disease ulcerative colitis are at increased risk of developing colon cancer. New data generated by Naofumi Mukaida and colleagues at Kanazawa University, Japan, identified a central role for the soluble factor TNF-alpha in the development of colon cancer in mice in which inflammation of the bowel was induced by administration of azoxymethane (AOM) followed by repeated dextran sulfate sodium (DSS) ingestion. Expression of TNF-alpha was increased in the colon of normal mice treated with AOM and DSS and this was followed by the development of tumors in the colon. Mice lacking one of the receptors for TNF-alpha and mice treated with an antagonist of TNF-alpha were markedly protected from the effects of treatment with AOM and DSS, developing less inflammation of the colon and fewer tumors in the colon. As suggested by the authors, and by Ezra Burstein and Eric R. Fearon in an accompanying commentary, these data provide clear rationale for the idea that drugs antagonizing TNF-alpha (such as those used to treat individuals with rheumatoid arthritis) might be useful in reducing the risk of colon cancer in individuals with ulcerative colitis.


'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

Page: 1

Related medicine news :

1. How IAP antagonist chemicals kill tumors
2. Prominent Respiratory Therapist and Author Joins StopSmokingConnection.com as a COPD Expert
3. Transports Phase 2 Data Show Single Treatment SoloVir(TM) ETS Significantly Stops Progression of Cold Sore Episode
4. Statin Benefits Persist After Treatment Stops
5. How vitamin C stops the big C
6. Vaccine Stops Alzheimers Brain Tangles
7. New Colon Cancer Test Might Spot Trouble Earlier
8. New Colonial Life Brand Clarifies Companys Strengths
9. Colonoscopy fears overcome when patients support patients
10. Colon cancer risk in US traced to common ancester
11. Photo: KFC Colonel Original and Look-a-Like Share Eye Treatment Success Story
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2014)... Alan Mozes HealthDay Reporter ... patients burdened by stress and family conflicts before surgery ... operation, a new study suggests. Investigators found that ... a nearly three times greater risk for complications compared ... life. "We,ve long known that patient quality of ...
(Date:9/19/2014)... using intact cells to treat and cure disease ... it is hindered by the inability of doctors and ... of these cells in patients without resorting to invasive ... September 17 in the online journal Magnetic Resonance ... San Diego School of Medicine, University of Pittsburgh and ...
(Date:9/19/2014)... --- Domestic violence occurs at least as frequently, ... compared to opposite-sex couples, according to a review ... , Previous studies, when analyzed together, indicate that ... of lesbian, gay and bisexual individuals. However, a ... paints an incomplete picture of the true landscape, ...
(Date:9/19/2014)... (PRWEB) September 20, 2014 As summer vacations ... DMD in Queens, NY now reminds area patients about the ... 80% of our population affected by gum disease, there is ... , For over 20 years Dr. Krishnan has treated patients ... office location. “Most patients that come in due to common ...
(Date:9/19/2014)... M.D., a second-year resident in the Department of ... Medicine and Health Sciences, received at $154K grant ... presence of diffuse brain swelling and injury in ... epidemiological studies, intracerebral hemorrhage accounts for less than ... least treatable form of stroke, with the highest ...
Breaking Medicine News(10 mins):Health News:Family Squabbles Can Derail Recovery From Cancer Surgery 2Health News:Family Squabbles Can Derail Recovery From Cancer Surgery 3Health News:A better way to track emerging cell therapies using MRIs 2Health News:Domestic violence likely more frequent for same-sex couples 2Health News:New York Periodontist Dr. Prabha Krishnan Now Raises Awareness about the Dangers of Untreated Decay, Gingivitis and Gum Disease During Self-Awareness Month 2Health News:New York Periodontist Dr. Prabha Krishnan Now Raises Awareness about the Dangers of Untreated Decay, Gingivitis and Gum Disease During Self-Awareness Month 3Health News:GW researcher receives grant to study brain swelling following bleeding in the brain 2
... use of designated drivers and open dialogue between parents ... ... Attorney General Bob,McDonnell today launched a campaign aimed at preventing drunk driving ... on stations throughout the state. The spots are timed to,coincide with the ...
... Third ... Straight Year, FLINT, Mich., Oct. 26 ... Medicaid health,plans have been recognized by U.S. News & World Report as ... top 50,Commercial plans and the top 25 plans for both Medicare and ...
... website allows consumers to share experiences on anti-aging and ... ... ( http://www.realself.com ),today announced the public launch of the first consumer ... lifestyle choices. On RealSelf.com, consumers engage in an,open and honest conversation ...
... Help End Insurance Coverage Exclusions for,Pre-existing Conditions for ... The National Patient,Advocate Foundation (NPAF) -- a ... avenues of improved patient access to health,care through ... levels -- today,praised Senator Jay Rockefeller (D-WV) for ...
... 26 Uroplasty, Inc. (Amex:,UPI) announced today that ... of fiscal 2008 ended September 30, 2007, before ... Company will host a conference call to,discuss these ... a.m. Central,Time. David Kaysen, President and Chief Executive ...
... YORK, Oct. 26 American Oriental,Bioengineering, Inc. (NYSE: ... of,plant-based pharmaceutical and nutraceutical products in China, today,announced ... in,November. The Company will present at the ... November 6, 2007 at the Waldorf-Astoria,Hotel in New ...
Cached Medicine News:Health News:Virginia Attorney General Addresses Drunk Driving and Underage Drinking in New Radio Campaign 2Health News:Consumers Open Up on RealSelf.com About 'Getting Work Done' 2Health News:Consumers Open Up on RealSelf.com About 'Getting Work Done' 3Health News:National Patient Advocate Foundation Hails Senator Rockefeller for Introducing Bill Protecting Patient Access to Health Coverage 2Health News:American Oriental Bioengineering Announces Participation in November Healthcare Conferences 2
(Date:9/19/2014)... Sept. 19, 2014  For Cloud Pharmaceuticals, Inc., ... and development, partnering is an integral part of ... design new drugs and identify early stage, preclinical, ... further their development. The company also partners with ... this business model, Cloud Pharmaceuticals will be participating ...
(Date:9/19/2014)... 2014  Diplomat, the nation,s largest independent specialty pharmacy, ... to the Board of Directors on September 15, 2014. ... serve as chair of the Audit Committee. ... financial, compliance and operating experience in the health care ... chief financial officer, chief operating officer and secretary of ...
(Date:9/19/2014)... -- Alere Inc. (NYSE: ALR ), a global ... in support of President Barack Obama,s Executive ... leader in rapid diagnostics for infectious disease, we commend ... the serious threat of antibiotic resistance. We look forward ... to promote the development of rapid point-of-care tests that, ...
Breaking Medicine Technology:Cloud Pharmaceuticals Announces Partnering Sessions and Presentation Schedule 2David Dreyer Appointed to Diplomat Board of Directors 2Alere Applauds President's Executive Order Combating Antibiotic-Resistant Bacteria 2
... SPRING, Md., March 30 The Laboratory Response Network ... public in health emergencies, will mark its first decade ... 2009.Founded in 1999 by the Association of Public Health ... (CDC) and the Federal Bureau of Investigation (FBI) to ...
... 29 Results from a new sub-,analysis of ... to normal,cholesterol levels and elevated high sensitivity C-reactive ... LDL-C <70mg/dL and hsCRP <2mg/L with,CRESTOR(R) (rosuvastatin calcium) ... to placebo than those who did not (65% ...
Cached Medicine Technology:Nation's Laboratory Response Network Marks First Decade of Protecting Public Health 2CRESTOR(R) Reduced CV Risk in Patients Achieving Low LDL and hsCRP Targets in New JUPITER Analysis 2CRESTOR(R) Reduced CV Risk in Patients Achieving Low LDL and hsCRP Targets in New JUPITER Analysis 3CRESTOR(R) Reduced CV Risk in Patients Achieving Low LDL and hsCRP Targets in New JUPITER Analysis 4
Anti-MPO ANCA EIA Auto-Immune Markers 013-MPO-96 Myeloperoxidase...
... the quantitative determination of Immunoglobulin E ... atopic allergic diseases such as atopic ... been shown to exhibit increased total,immunoglobulin ... is also known as the,reagenic antibody. ...
... Immune Complexes from patient serum or plasma, standards ... onto microtiter wells. After a washing step, ... binds to the Fc region of human IgG. ... is pipetted followed by a stopping step. ...
... Images captured with the CR-DGi can be viewed ... just the beginning. Because the images are ... applications, such as telemedicine and electronic filing. ... with quality and ease of use. It's the ...
Medicine Products: