Navigation Links
TNF-alpha antagonist stops inflammation-induced colon cancer in its tracks
Date:1/24/2008

Individuals with the inflammatory bowel disease ulcerative colitis are at increased risk of developing colon cancer. New data generated by Naofumi Mukaida and colleagues at Kanazawa University, Japan, identified a central role for the soluble factor TNF-alpha in the development of colon cancer in mice in which inflammation of the bowel was induced by administration of azoxymethane (AOM) followed by repeated dextran sulfate sodium (DSS) ingestion. Expression of TNF-alpha was increased in the colon of normal mice treated with AOM and DSS and this was followed by the development of tumors in the colon. Mice lacking one of the receptors for TNF-alpha and mice treated with an antagonist of TNF-alpha were markedly protected from the effects of treatment with AOM and DSS, developing less inflammation of the colon and fewer tumors in the colon. As suggested by the authors, and by Ezra Burstein and Eric R. Fearon in an accompanying commentary, these data provide clear rationale for the idea that drugs antagonizing TNF-alpha (such as those used to treat individuals with rheumatoid arthritis) might be useful in reducing the risk of colon cancer in individuals with ulcerative colitis.


'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

Page: 1

Related medicine news :

1. How IAP antagonist chemicals kill tumors
2. Prominent Respiratory Therapist and Author Joins StopSmokingConnection.com as a COPD Expert
3. Transports Phase 2 Data Show Single Treatment SoloVir(TM) ETS Significantly Stops Progression of Cold Sore Episode
4. Statin Benefits Persist After Treatment Stops
5. How vitamin C stops the big C
6. Vaccine Stops Alzheimers Brain Tangles
7. New Colon Cancer Test Might Spot Trouble Earlier
8. New Colonial Life Brand Clarifies Companys Strengths
9. Colonoscopy fears overcome when patients support patients
10. Colon cancer risk in US traced to common ancester
11. Photo: KFC Colonel Original and Look-a-Like Share Eye Treatment Success Story
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/20/2017)... Minneapolis, Minnesota (PRWEB) , ... July 19, 2017 ... ... in healthcare experience, recently hiring senior healthcare project manager, Josh Christensen. As a ... the nation and looks to further its healthcare resume in the Midwest with ...
(Date:7/20/2017)... ... July 20, 2017 , ... “Lucky the Buffalo and Her Adventures”: a collection of heartwarming children’s ... Bieniek. Edward Steven Bieniek Jr. was born in Toledo, Ohio. He attended Woodward ... tech. He is married to a brilliant woman with a caring heart named Tiina, ...
(Date:7/18/2017)... ... ... an international clinical trial, led in part by a UC Davis School of Medicine expert, ... for a subgroup of patients. , In a paper just published online in the journal ... 18 countries describe the clinical benefit of using the drug ataluren for a certain group ...
(Date:7/18/2017)... ... , ... Heritage Woods of Benton, a Gardant affordable assisted living community is ... , The community, which is located at 1305 Bailey Lane in Benton, Illinois, serves ... maintain their independence. , The lunch menu will include Hawaiian chicken, meatballs and coleslaw. ...
(Date:7/17/2017)... ... July 18, 2017 , ... ... PICOPLUS 450 ps pulse width and a new published paper entitled ‘Pattern ... in tissue-mimicking phantom’ featured in Nature’s specialty journal Scientific Reports May 08, ...
Breaking Medicine News(10 mins):
(Date:6/30/2017)... June 30, 2017  AVACEN Medical (AVACEN) announced the publication of ... describes the use of its AVACEN Treatment Method to ... fibromyalgia. ... AVACEN Medical ... chronic widespread pain. It affects approximately 200 to 400 million people worldwide ...
(Date:6/27/2017)...  Therapix Biosciences Ltd. (Nasdaq: TRPX ) ... development of cannabinoid-based drugs, today announced that the Company ... New York, NY on Wednesday, ... offering (IPO) of American Depository Shares (ADSs) listed on ... Dr. Elran Haber, Ph.D., Chief Executive Officer of Therapix, ...
(Date:6/20/2017)... Netherlands and LAGUNA HILLS, Calif. ... the presentation of new data that validate the use ... risk stratify patients with multiple myeloma (MM). In a ... the European Hematology Association (EHA) in Madrid, ... value of MMprofiler for identifying high-risk elderly patients. ...
Breaking Medicine Technology: