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TNF Treatment for Rheumatoid Arthritis Boosts Skin Cancer Risk
Date:9/7/2011

WEDNESDAY, Sept. 7 (HealthDay News) -- Treating rheumatoid arthritis (RA) patients with tumor necrosis factor (TNF) inhibitors appears to increase their risk of developing skin cancer, a new review of prior research indicates.

However, TNF inhibitors, which include infliximab (Remicade), adalimunab (Humira), and etanercept (Enbrel), do not appear to boost the risk for developing other forms of cancer, the researchers added.

The findings stem from an analysis of 21 previous studies conducted between 1998 and 2010, as well as eight study summaries that had been presented at research conferences during the same timeframe. All the studies had focused on the potential for cancer risk in association with the use of standard TNF inhibitors.

"This systematic review and meta analysis provides reassurance to physicians and patients that the treatment of [rheumatoid arthritis] with TNF inhibitors does not increase the risk of malignancy, particularly lymphoma," the French study team said in a news release from Annals of the Rheumatic Diseases, which published the report in its current online issue.

"However, it does appear to increase the risk of skin cancer, including melanoma," added the French team, led by Prof. Xavier Mariette from Paris-Sud University's rheumatology service in Ile de France.

The authors noted that RA has previously been shown to increase the risk for developing certain types of cancer, including both lung cancer and lymphoma, while decreasing the risk for other cancers, including bowel and breast.

However, the question of TNF inhibitor treatments as a cancer risk has remained a subject of debate.

All told, the current review looked at a collection of studies involving more than 40,000 patients who had been exposed to nearly 150,000 years of TNF inhibitor drugs.

Seven of the studies indicated no notable risk increase for any type of cancer associated with the use of TNF med
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