Navigation Links
TGen researchers map potential genetic origins, pathways of lung cancer in nonsmokers
Date:1/9/2012

ns and pathway alterations that could have led to the development and progression of their specific lung cancer.

"In the never-smoker with early-stage cancer, there are very few mutations in the genome, but when we looked at the whole transcriptome, we see differences in gene expression," Whitsett said.

In the never-smoker with late-stage disease, researchers found mutations in what Whitsett called "classic tumor-suppressor genes." He and his colleagues hypothesize that mutations of the tumor-suppressor genes might be a factor in late-stage lung cancer in never-smokers.

Notably, the researchers reported that these never-smokers' tumors lacked alterations in common genes associated with lung cancer such as EGFR, KRAS and EML/ALK translocations. This finding makes these patients ideal cases for the discovery of new mutations that may drive lung adenocarcinomas in never-smokers, according to the researchers.

Whitsett said that using WGS and WTS to identify cancer origins "has become a way to really dive down into an individual tumor to try to understand the pathways that may be driving that tumor and identify what therapeutic interventions may be possible."

The researchers are now validating these findings in about 30 never-smokers with lung adenocarcinoma and about 60 clinically matched smokers with lung adenocarcinoma.


'/>"/>
Contact: Steve Yozwiak
syozwiak@tgen.org
602-343-8704
The Translational Genomics Research Institute
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
2. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
3. Researchers discover new way to kill pediatric brain tumors
4. Researchers Who Discovered First Genes for Stuttering will Present Findings to the National Stuttering Association
5. Researchers create drug to keep tumor growth switched off
6. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
7. GUMC researchers say flower power may reduce resistance to breast cancer drug tamoxifen
8. Clemson researchers develop hands-free texting application
9. Researchers find biomarkers in saliva for detection of early-stage pancreatic cancer
10. Researchers chart genomic map spanning over 2 dozen cancers
11. Researchers discover second protective role for tumor-suppressor
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2015)... On February 21st, 2015, Per Wickstrom had the ... contributor Karen Salkin at Durkin Entertainment’s EcoLuxe Lounge, sponsored ... of which Wickstrom is the founder. Making appearances at ... EcoLuxe Lounge is a gathering of some of the ... and services. Among the many roles that she has ...
(Date:4/24/2015)... Anchor Health Administrators (Anchor), specialists in Long-Term Care ... exclusive agreement with LTC Solutions for All LLC (SFA) ... , Anchor has more than 18 years of experience ... and is currently the designated advocate for the American ... member benefit. , “I am very pleased to be ...
(Date:4/24/2015)... (PRWEB) April 24, 2015 With years ... , UGA is now proud to be partnered with ... of 16,000 animals a year. This partnership has brought ... their animals. , After providing an in-house payment ... Medical Teaching Hospital (VMTH) wanted to increase financing options ...
(Date:4/24/2015)... (PRWEB) April 24, 2015 “ Opera ” ... Report, which features the latest and coolest technology products available ... of NewsWatch, conducted the review and shared with viewers how ... Without web browsers, surfing the internet would not be in ... other and the Opera browser is no different. Celebrating their ...
(Date:4/24/2015)... April 24, 2015 Qualis Health, ... organizations, has published a new resource for practicing ... The guide to Quality and Resource Use Reports ... & Medicare Services (CMS) to help practices interpret ... streamline resources, and identify care coordination opportunities to ...
Breaking Medicine News(10 mins):Health News:Karen Salkin Talks with Per Wickstrom at the 2015 EcoLuxe Lounge and the "Salute to the Oscars" Celebration 2Health News:University of Missouri Veterinary Medical Teaching Hospital Teams with UGA 2Health News:A Web Browser That Connects over 350 Million People was Featured on NewsWatch Television 2Health News:Qualis Health Publishes Guide to Help Physician Practices Assess and Improve Quality 2
... variants in the DNA of 486 people infected with HIV that ... virus and delay the onset of full-blown AIDS. ... for an HIV vaccine that would work by boosting the protective ... bodys own immune system overcome an infection. One of the genes ...
... may have ended 150 years ago but that need not ... ambience in a majestic 17th century garden . ... has made known plans to open up a part of ... for weddings. ,The magnificently laid and maintained gardens, ...
... passed snide remarks about her, claiming that the actress is too ... Ashton Kutcher tied the knot in September 2005, and the actress ... ,Lesley Guynes, who is separated from Moores half-brother commented that the ... she was old. ,I think Demi is getting too ...
... study by researchers has claimed that Chinas desire to ... monkeys in their infancy in the Mount Huangshan Scenic ... ,According to National Geographic, the skyrocketing infant mortality of ... to a restricted range and regularly competing for corn ...
... toughen anti-smoking laws, restricting smoking in public places and ... further approved a Health and Family Welfare Ministry proposal ... Act in the first week of the monsoon session ... told reporters after a Cabinet meeting in New Delhi. ...
... food cravings and keeping them in check may be ... first six-month phase of the study provides new insights ... their role in weight control. ,Cravings are ... Susan Roberts, PhD, director of the USDA HNRCAs Energy ...
Cached Medicine News:Health News:Experts Identify Vaccine Target for HIV 2Health News:Experts Identify Vaccine Target for HIV 3Health News:Now You can Marry in a Mughal Ambience, If You Wish to 2Health News:Chinese Eco-tourism Causing Infanticide Among Tibetan Monkeys 2Health News:Government to Toughen Its Anti-smoking Laws 2Health News:Weight Management Achieved by Controlling and Not Suppressing Food Cravings 2
(Date:4/24/2015)... , April 24, 2015  IGI Laboratories, Inc. ... based specialty generic pharmaceutical company, announced the Company ... on Tuesday, April 28, 2015 to discuss the 1st ... to listen to the call by dialing 1-888-346-3479. International ... Participants should ask to be joined into the IGI ...
(Date:4/24/2015)... April 24, 2015  Span-America Medical Systems, Inc. ... its fiscal 2015 second quarter results on Thursday, April ... The company will conduct a conference call ... to review the company,s financial and operating results for ... broadcast of the conference call will be available ...
(Date:4/24/2015)... Introduction of new ... tools for radiosurgery/SBRT   The "Elements" ... enhancing the workflow for difficult to treat indications ... - comes full circle with the introduction of ... Elements enable on-the-fly generation of consistent treatment plans ...
Breaking Medicine Technology:Brainlab Introduces New Generation of VMAT* for Brain and Spine at 3rd ESTRO in Barcelona 2
... BP 900 offers three magnifications ... routine practice, the BP 900 ... and progressive functionality. Two optional ... one for digital photography, are ...
... 400 System is an automated multiplexing platform ... SNP detection, pathogen sequence detection and pharmacogenetics ... be applied to an open and flexible ... be reused until all tests sites have ...
... for venous pressure monitoring, blood sampling, ... Turbo-Flo polyurethane PICC line sets offer:, ... Micropuncture Introducer Needle, Biocompatible ... trimmed to patient specific anatomy. Remove ...
Cable connections for 5 different adapters: Storz, ACMI, Pentax, Wolf and Olympus....
Medicine Products: