Navigation Links
TGen partner, PBS-Bio, makes first breakthrough drug analysis
Date:6/18/2010
PHOENIX, Ariz. June 18, 2010 Predictive Biomarker Sciences Inc. (PBS-Bio) has completed its first drug analysis, enabling Canadian biotech company PharmaGap Inc. to significantly advance a potentially significant anti-cancer medication.
PharmaGap is an early-stage biotech company based in Ottawa, Ontario developing novel peptide compounds for cancer. Its lead compound, GAP-107B8, exhibits potent cytotoxic characteristics against cancer cells and has recently completed screening at the National Cancer Institute in Bethesda, Md., and was the subject of a data poster by researchers at the Ottawa Hospital Research Institute at the recent American Association for Cancer Research meeting in Washington, D.C.
Proprietary real-time computer imaging technology from PBS-Bio has been instrumental in assisting PharmaGap to determine the drug's potential mechanism of action and thereby identifying suitable cancers to target for eventual clinical use.
As part of its pre-clinical development program, PharmaGap hired Phoenix-based PBS-Bio to analyze more specifically how the drug worked. PBS-Bio is a privately held, for-profit corporation owned in part by the non-profit Translational Genomics Research Institute (TGen).
Data from the PBS-Bio analysis indicated that GAP-107B8 rapidly compromises the outer membrane of colorectal cancer cells, leading to either oncolytic or apoptotic cell death, while having significantly less affect on non-cancerous cells.
Unlike many protein kinase inhibitor drugs now in development, GAP-107B8 works within mere minutes through "an assault on the plasma membrane," said Dr. Isabella Steffensen, a PharmaGap pre-clinical development consultant. She said that GAP-107B8 appears to be reacting with surface receptors apparently more prevalent on cancer cells than normal cells.
By providing PharmaGap with a more accurate analysis of how the drug functioned, PBS-Bio saved the company months of rese
'/>"/>
| Contact: Steve Yozwiak syozwiak@tgen.org 602-343-8704 The Translational Genomics Research Institute Source:Eurekalert |
Related medicine news :
1. After a fight with a partner, brain activity predicts emotional resiliency
2. Life Line Screening Proudly Supports NBC's Skate for the Heart in Honor of Longtime Partner, Peggy Fleming
3. Revolutionary scale makes losing weight easier than ever
4. "How Facebook Makes Lonely People Even Lonelier" Revealed by Distinguished University of Chicago Professor in Interview with Brian Vaszily on IntenseExperiences.com
5. Spending time in nature makes people feel more alive, study shows
6. ACR task force makes recommendations for improving relationships between radiologists and hospitals
7. ORCS Web, Inc Makes Available WCF RIA Services
8. TakeThemAMeal.com Surpasses 100,000 Meal Milestone; Web Site Makes Caring For Friends and Family Easier
9. Fight Obesity with Fitness Entrepreneur's New Product That Makes Inline Skating Safer
10. Safety Training Makes for Safer Mining
11. Wine Enthusiast Facebook Sweepstakes Makes One in Twenty a Winner
Post Your Comments:
(Date:5/24/2013)... News) -- The number of U.S. patients admitted ... in an emergency room has increased by nearly ... study, conducted by researchers at the George Washington ... in Washington, D.C., found that patients wait five ... being admitted to the ICU. The researchers said ...
(Date:5/24/2013)... Bay, Australia (PRWEB) May 24, 2013 ... show off their favorite sunglasses all while learning ... longer with replacement lenses. Contestants only need ... wearing their sunglasses and "like" The Sunglass Fix ... winning Sunglass fix is the largest lens ...
(Date:5/24/2013)... aortic valve implantation (TAVI) is effective and safe in ... results from a multicentre Asian registry reported at EuroPCR ... a treatment option for selected patients with symptomatic severe ... North American or European centres," Paul Chiam, senior consultant ... conference. He explained that it is unknown whether the ...
(Date:5/24/2013)... In a coup that surely made other ... of the Estetica Institute of the Palm Beaches performed eye ... popular morning show, “The Mo & Sally Morning Show.” The ... satisfaction with the results, giving Dr. DeLange and the team ... Beach Gardens, very valuable free publicity. , Dr. DeLange, the ...
(Date:5/24/2013)... 2013 CBT News.com recently announced the addition ... web-based retail automotive industry news organization with 12 years experience ... to join a group that’s so forward-thinking in their approach,” ... online video content is on the rise.” , Atlanta born ... and segued into advertising at Cycle News and Boating World. ...
Breaking Medicine News(10 mins):Health News:Sharp Rise in ICU Admissions From U.S. Emergency Rooms 2Health News:Break the Sunglass Mold – Reuse 'Em, Don’t Toss 'Em then Enter the SunglassFIX Photo Contest to Win 2Health News:Registry confirms TAVI efficacy and safety in Asian patients 2Health News:Dr. Greg DeLange of the Estetica Institute Recently Performed Eye Surgery on Both Members of Popular Morning Radio Team 2[0] Sharp Rise in ICU Admissions From U.S. Emergency Rooms [0] Break the Sunglass Mold – Reuse 'Em, Don’t Toss 'Em then Enter the SunglassFIX Photo Contest to Win[0] Registry confirms TAVI efficacy and safety in Asian patients[0] Dr. Greg DeLange of the Estetica Institute Recently Performed Eye Surgery on Both Members of Popular Morning Radio Team[0] Tom Gonter to Drive Sales at Retail Automotive News Organization CBT News
... HealthDay Reporter , WEDNESDAY, July 27 (HealthDay News) ... emotional or behavioral issues often face tough social and ... , Tracking the progress of more than 1,450 students ... U.S. researchers found that one-third coped with special health ...
... research out of UCLA has found that Latinos living in ... the country are far less likely to spend for ... they do spend than the white population. ... they stay in the country, spending disparities remain large over ...
... discoveries in the field of cognitive neuroscience hold great ... a significant gap between such scientific discoveries and the ... New York Academy of Sciences and the ... conference on September 22-24, 2011 in Aspen, Colorado, ...
... BROOK, Ill. (July, 27, 2011) Using computed tomography (CT), ... lungs of patients with chronic obstructive pulmonary disease (COPD) that ... worsen. Their findings are published online in the journal ... the air sacs of the lungs, and is a leading ...
... risk factor for COPD, but have not accounted for ... Women,s Hospital, the University of Colorado, and National Jewish ... from the COPD Gene Study, capturing parental smoking and ... findings noted a strong risk factor for COPD when ...
... Brigham and Women,s Hospital (BWH) uses a new imaging technique, ... that are activated when patients with low back pain have ... published in the August issue of the journal Anesthesiology ... providing tools to objectively describe someone,s chronic pain which is ...
Cached Medicine News:Health News: Special Needs Kids Bullied More, Fare Poorly at School 2Health News: Special Needs Kids Bullied More, Fare Poorly at School 3Health News:Big gap exists on health care spending between Latinos and whites, study finds 2Health News:Conference: Improving K-12 education with cutting-edge cognitive neuroscience research 2Health News:CT shows changes in lungs associated with COPD flare-ups 2Health News:New imaging technique captures brain activity in patients with chronic low back pain 2 Special Needs Kids Bullied More, Fare Poorly at SchoolBig gap exists on health care spending between Latinos and whites, study findsConference: Improving K-12 education with cutting-edge cognitive neuroscience research CT shows changes in lungs associated with COPD flare-upsFamily history a risk factor for COPDNew imaging technique captures brain activity in patients with chronic low back pain
(Date:5/23/2013)... y PARÍS, 24 de mayo de ... ), un destacado desarrollador y fabricante de herramientas ... la diagnosis y tratamiento de la enfermedad vascular ... del ensayo ADVISE ( Ad enosine V ... E valuation) II durante la sesión de ensayo ...
(Date:5/23/2013)... 23, 2013 Amgen (NASDAQ: AMGN ) ... Healthcare Conference on Thursday, May 30, 2013, at the Westin ... 9:20 a.m. Eastern Daylight Time. Arvind Sood ... at the conference. Live audio of the presentation can be ... , under Investors. A replay of the webcast will also ...
(Date:5/23/2013)... May 23, 2013 Nephros, Inc. (OTC Bulletin ... device company that develops and sells high performance liquid ... rights offering. In addition, the concurrent temporary reduction in ... on May 17, 2013. Nephros estimates that ... the rights offering. A portion of the proceeds will ...
Breaking Medicine Technology:Volcano anuncia los resultados preliminares del estudio ADVISE II y su inclusión en el ensayo SYNTAX2 2Volcano anuncia los resultados preliminares del estudio ADVISE II y su inclusión en el ensayo SYNTAX2 3Volcano anuncia los resultados preliminares del estudio ADVISE II y su inclusión en el ensayo SYNTAX2 4Volcano anuncia los resultados preliminares del estudio ADVISE II y su inclusión en el ensayo SYNTAX2 5Volcano anuncia los resultados preliminares del estudio ADVISE II y su inclusión en el ensayo SYNTAX2 6Nephros Announces Completion of Rights Offering 2Nephros Announces Completion of Rights Offering 3Nephros Announces Completion of Rights Offering 4... , CRANBURY, N.J. , Feb. 1 ... producer in North America , today announced that it will host ... 10:00 am ET to discuss its fourth quarter and full ... will be issued on Wednesday, February 17, 2010 after market ...
... , , ... , WHAT: Each February, the American Dental Association (ADA) ... importance of oral health. Developing good habits at an early age ... on a lifetime of healthy teeth and gums. , (Logo: ...
Cached Medicine Technology:Innophos Holdings, Inc. Schedules Call to Discuss Fourth Quarter and Full Year 2009 Results 2Innophos Holdings, Inc. Schedules Call to Discuss Fourth Quarter and Full Year 2009 Results 3February is National Children's Dental Health Month -- 'Remember to Brush and Floss Every Day' is the Message -- Kids With Braces Need to be Extra Vigilant 2February is National Children's Dental Health Month -- 'Remember to Brush and Floss Every Day' is the Message -- Kids With Braces Need to be Extra Vigilant 3Anterior Chamber Needle, 30 g. Angled. 5 mm angled tip. Overall length 20 mm. 5/box....
Anterior Chamber Needle, 23 g. Angled. 7 mm angled tip. Overall length 23 mm. 5/box....
Anterior Chamber Needle, 20 g. Angled. 7 mm angled tip. Overall length 23 mm. 5/box....
Hydrodissection / Aspiration Cannula, 25 g. Angled with right hook. 10 mm angled shaft with 2.5 mm right hook tip. Overall length 20 mm. 5/box....
Medicine Products:| Copyright © 2003-2012 Bio-Medicine. All rights reserved. ABOUT | CONTACT US | DISCLAIMER | PRIVACY POLICY | TERMS AND CONDITIONS |  |