Navigation Links
TGen licenses first drug for patient use in clinical care

PHOENIX, Ariz. May 4, 2011 The Translational Genomics Research Institute (TGen) has licensed its first drug, a unique compound that targets cancer tumors by modifying the actions of proteins.

Today's announcement is another key fulfillment of TGen's primary mission: To move laboratory discoveries more rapidly into therapeutics that can immediately help patients improve their quality of life.

The drug, ONCO-101, is being licensed to Syracuse, N.Y.-based Oncoholdings Inc., a pharmaceutical company focused on the acquisition and development of innovative anti-cancer compounds.

Oncoholdings, in turn, has contracted with a TGen subsidiary, Scottsdale-based TGen Drug Development (TD2), to help guide continued pre-clinical tests, and eventually move ONCO-101 into first-in-human clinical trials, where it could immediate help cancer patients.

"This milestone is a significant accomplishment that validates the clinical groundwork we established when forming TGen," said Dr. Jeffrey Trent, TGen President and Research Director. "Because ONCO-101 could potentially change the way patients with ovarian and endometrial cancer are treated, we hope this is but the first of many compounds that benefit patients battling life-threatening illnesses."

Licensing ONCO-101 comes nearly nine years after the establishment of TGen, an integral piece of Arizona's bioscience initiative. The goals of that initiative are to: enable scientific discoveries; improve the quality of health care, especially for Arizona residents; and diversifying the state's knowledge-based economy.

ONCO-101 was developed at TGen in the course of research into the design of drugs that selectively target key proteins involved in cancers.

TGen granted Oncoholdings the exclusive license to further develop ONCO-101, an epigenetic agent, or compound, that decides how active proteins become. Currently, there are only four epigenetic drugs on the market, and they are only approved to treat blood cancers. ONCO-101 would be the first epigenetic agent to attack solid tumors.

"This class of therapeutic agents has yet to find its place in the market for the treatment of solid tumors," according to Jeffrey Evans, Ph.D. and Chief Operating Officer of Oncoholdings. "ONCO-101 works by allowing the regular function of normal cells, while disrupting the ability of abnormal cells to reproduce, effectively stopping the cancer."

Oncoholdings expects to announce the acquisition of its second group of products in the second quarter of 2011.


Contact: Steve Yozwiak
The Translational Genomics Research Institute

Related medicine news :

1. The Indiana Clinical and Translational Science Institute (CTSI) Licenses GeneGos Eureka and MetaCore Platforms
2. Cells talk more in areas Alzheimers hits first, boosting plaque component
3. Study is the first to link sleep duration to infant growth spurts
4. Cedars-Sinai to hold first annual conference on stem cell therapies for neurological disorders
5. Success of First World Congress of Pediatric Urology underscores increasing importance of specialty
6. Alzheimers diagnostic guidelines updated for first time in decades
7. University of Granada researchers make the first bioartificial organ in Spain
8. First clinical trial of gene therapy for pain reported by U-M neurologists
9. Simple chemical cocktail shows first promise for limb re-growth in mammals
10. John Theurer Cancer Center first in New Jersey to offer complete capabilities of Provenge
11. Study provides first link between 2 major Parkinsons genes
Post Your Comments:
(Date:12/1/2015)... ... December 01, 2015 , ... ... as a Modern Man for 2015. , Angeleno Magazine is a division ... States. Established in 1994, Modern Luxury includes more than 50 magazine titles across ...
(Date:12/1/2015)... , ... December 01, 2015 , ... ... Center Enterprise Authorized Technology Provider (ATP) status from Cisco. This designation recognizes Tympani ... support Cisco Unified Contact Center solutions targeted to the high-end enterprise contact center ...
(Date:11/30/2015)... , ... November 30, 2015 , ... ... Beard and Brooke Bennett are collaborating with brands across various categories through traditional ... influential figures make up an elite group of Gold Medal Moms who can ...
(Date:11/30/2015)... & Caicos Islands, BWI (PRWEB) , ... December 01, 2015 , ... ... 2015. Recently Caribbean Journal, one of the leading digital news sites highlighting Caribbean ... top reason? The weather. While much of North America shivers under chilly grey ...
(Date:11/30/2015)... Garden City, NY (PRWEB) , ... December 01, 2015 , ... ... as a 2015-2016 inductee into its VIP Woman of the Year Circle. She ... is the nation’s leading networking organization exclusively for professional women, boasting more than 850,000 ...
Breaking Medicine News(10 mins):
(Date:12/1/2015)... , BANGALORE, India and ... -- Mylan N.V. (NASDAQ, TASE: MYL) today announced that it ... approval and for developing country markets funded by international ... 300 mg + Efavirenz 400 mg) for $99 per ... Access Initiative (CHAI) to develop TLE400. The significantly reduced ...
(Date:12/1/2015)... diciembre de 2015  AccuTEC Blades, una ... precisión, develó hoy un nuevo logo corporativo ... El nuevo logo destaca la experiencia de ... de productos con cuchillas donde "el borde ... --> ...
(Date:12/1/2015)... 2015 Breg, Inc ., a premier ... that it has been awarded three contracts by Novation, ... Novation will have access to improved pricing for Breg,s ... soft goods dedicated to advancing orthopedic care.  ... U.S. population, rising prevalence of chronic conditions and the ...
Breaking Medicine Technology: