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TGen-led team is 1 of 7 selected for $1 million skin-cancer grants
Date:8/3/2009

r study by a GenoMEL member group has identified a third.

"We propose here to extend this collaborative effort by screening all genes at these three chromosomal locations for disease-predisposing mutations in melanoma families. We will also work towards identifying additional susceptibility genes by sequencing the entire genomes of patients from five of the largest melanoma families.

"The identification of novel predisposition genes is a major first step towards accurately estimating individualized disease risk and ultimately implementing disease prevention and early-detection strategies for at-risk individuals. Further, characterization of the molecular mechanisms underlying melanoma susceptibility may lead to a better understanding of the processes underlying melanoma development and progression, and ultimately to novel strategies for melanoma treatment."

The other teams receiving the latest round of MRA grants are:

Developing Melanoma Screening in Primary Care
Principal Investigators:
Team Lead: Martin A. Weinstock, M.D., Ph.D., Rhode Island Hospital and Brown University
Maryam Asgari, M.D., M.P.H., Kaiser Foundation Research Institute
Melody Eide, M.D., M.P.H., Henry Ford Health System
Suzanne Fletcher, M.D., M.Sc., Harvard Pilgrim Health Care and Harvard Medical School
Alan Geller, R.N., M.P.H., Harvard School of Public Health
Allan Halpern, M.D., M.S., Memorial Sloan-Kettering Cancer Center

Manipulating Immune Regulation in Adoptive T-cell Therapy for Melanoma Principal Investigators:
Team Lead: Jeffrey Weber, M.D., Ph.D., H. Lee Moffitt Cancer Center and Research Institute
Patrick Hwu, M.D., M.D. Anderson Cancer Center

Identification and Validation of Combination Therapies for Melanomas
Principal Investigators:
Team Lead: Michael J. Weber, Ph.D., University of Virginia
Levi Garraway, M.D., Ph.D., Dana-Farber Cancer Institute
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Contact: Steve Yozwiak
syozwiak@tgen.org
602-343-8704
The Translational Genomics Research Institute
Source:Eurekalert

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