Navigation Links
TGen-led study identifies genes associated with unhealthy liver function
Date:10/1/2013

PHOENIX, Ariz. Oct. 1, 2013 A groundbreaking study of nearly 2,300 extremely obese diabetes patients, led by the Translational Genomics Research Institute (TGen), has identified genes associated with unhealthy liver function.

This is believed to be the nation's first large-scale genome-wide association study in overweight patients with diabetes.

Results of the study, done in conjunction with the Geisinger Health System, will be presented at the 64th annual meeting of the American Association for the Study of Liver Diseases Nov. 1-5 at the Walter E. Washington Convention Center in Washington, D.C.

The study Genome-wide analysis identifies loci associated with total bilirubin levels, steatosis, and mild fibrosis in nonalcoholic fatty liver disease looked at how genomic factors affect the development of non-alcoholic fatty liver disease. It was selected for presentation from among a record 3,139 submittals from around the world proposed for what also is known as The Liver Meeting 2013.

"These genetic factors could help us identify patients who are most at risk of developing non-alcoholic forms of fatty-liver disease (NAFLD), and which patients may be more likely to progress to severe forms of NAFLD, such as steatohepatitis (NASH)," said Dr. Johanna DiStefano, the study's principal investigator and lead author. Dr. DiStefano is Director of TGen's Diabetes, Cardiovascular and Metabolic Diseases Division.

NAFLD is the build up of extra fat in liver cells, not caused by alcohol. It is one of the most common causes of chronic liver disease. NASH is liver inflammation and damage caused by a buildup of fat in the liver, not caused by alcohol.

"Our results showed evidence for new genetic loci that may play a role in the biological mechanisms of NAFLD and NASH," said Dr. Glenn S. Gerhard, a faculty member of the Geisinger Obesity Institute and a co-investigator of the study.

"We discovered genes that may help identify those patients most at risk for the types of liver disease so severe that they could require transplants," said Dr. Gerhard, Administrative Director for the Institute for Personalized Medicine at Penn State University-Hershey.

Patients included in this study were those with extreme obesity enrolled in a bariatric surgery program.

The study identified evidence for association with markers in the neurocan gene (NCAN) on chromosome 19p12, and rs2501843 on chromosome 1.


'/>"/>

Contact: Steve Yozwiak
syozwiak@tgen.org
602-343-8704
The Translational Genomics Research Institute
Source:Eurekalert

Related medicine news :

1. Vitamin D3 Market in China and Global Regions 2013 Structure and Value Analysis in a New Research Study at DeepResearchReports.com
2. International Academy of Low Vision Specialists (IALVS) Supports Johns Hopkins Study Showing Americans with Macular Degeneration Tend to Stay Closer to Home
3. CU Cancer Center study: Young patients with metastatic colorectal cancer at higher risk
4. India Network Awards Travel Grant to Dr., Akshay Anand, Neurology Faculty to Present Research On the Role of Environment and Genes in the Study of Neurological Disorders
5. Study: New medical device extremely effective at preventing HIV in women
6. New Clinical Study Finds that Nutraceutical Deepak Chopra Endorphinate® Provides Effective, Safe Relief for Chronic Anxiety, Depression, Cravings & Pain Hypersensitivity
7. Study reveals differences in post-operative complications
8. FDA-approved antidepressant may combat deadly form of lung cancer, Stanford study finds
9. Global & China Diagnostic Reagent Industry 2013 Development Trends in a New Research Study Available at DeepResearchReports.com
10. Study of sister stem cells uncovers new cancer clue
11. Getting better together: New study looks at shared medical decision making
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/25/2016)... ... , ... Afrimesure specializes in providing clients with ideal measurement ... HVAC facilities. Their knowledgeable staff also takes care of the installation, IQ/OQ/PQ qualification ... a variety of MadgeTech systems available for sterilization and temperature monitoring, including the ...
(Date:5/25/2016)... ... May 25, 2016 , ... The University of San Francisco (USF) has named ... lead a team of more than 100 full-time faculty and staff, and serve as ... in late August. , Baker comes to USF from the University of Washington in ...
(Date:5/25/2016)... (PRWEB) , ... May 25, 2016 , ... "FCPX LUT ... quality of your footage," said Christina Austin - CEO of Pixel Film Studios. ... can quickly and easily add stylish color grades to their footage. A LUT is ...
(Date:5/25/2016)... ... 25, 2016 , ... First Choice Emergency Room , the largest network ... as the Medical Director of its new DeSoto facility. , “We are pleased ... location,” said Dr. James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. ...
(Date:5/24/2016)... Angeles, CA (PRWEB) , ... May 24, 2016 , ... ... study found that a group of people randomly assigned to reduce the amount of ... experienced a 12 percent drop in body weight enjoyed better sleep, improved quality of ...
Breaking Medicine News(10 mins):
(Date:5/23/2016)... , May 23, 2016 ... for the treatment of cancer and orphan genetic diseases, ... up to $4.4 million from the Israel Innovation Authority ... Israeli Ministry of Economy and Industry. The mission of ... entrepreneurship in various industries, including science and technology, while ...
(Date:5/23/2016)... Conn. , May 23, 2016   ... has entered into an agreement with Egalet Corporation ... patent claims. As part of the agreement the ... and will enable all three companies to develop ... properties. "This agreement reflects the commitment ...
(Date:5/20/2016)... India , May 20, 2016 ... Survey Report 2016 to Medical Devices of its ... and in-depth survey on the current state of ... overview of the industry like definitions, classifications, Specifications, ... information about manufacturing process like Raw Material Suppliers, ...
Breaking Medicine Technology: