Navigation Links
TGen finds therapeutic targets for rare cancer in children
Date:9/1/2010

PHOENIX, Ariz. Aug. 31, 2010 The first study of Ewing's sarcoma that screened hundreds of genes based on how they affect cell growth has identified two potential anti-cancer drug targets, according to a scientific paper by the Translational Genomics Research Institute (TGen) published this month in the journal Molecular Cancer.

Ewing's sarcomas are rare, but aggressive cancer lesions that occur most frequently in the bones of teenagers. They represent nearly 3 percent of all childhood cancers. Patients are treated with a combination of surgery, radiation and chemotherapy. This cancer can reoccur after surgical removal, and often spreads to the lungs, other bones and bone marrow. Once it spreads, or metastasizes, only 1 in 5 patients survive more than 5 years.

These lesions harbor unique chromosomal abnormalities that give rise to fusion genes that act as cancer-inducing proteins, or oncoproteins.

TGen researchers used RNAi-based phenotypic, or loss-of-function screening, a method of silencing hundreds of individual genes in a high-throughput format, to analyze 572 kinases that are expressed in human cells. Kinases are enzymes that modify other proteins. Using this technique, the authors discovered two protein kinases with important roles in the growth and survival of Ewing's sarcoma cells. Cancer cells died when investigators stopped the normal function of the two protein kinases called STK10 and TNK2.

"RNAi-based phenotypic profiling proved to be a powerful gene target discovery strategy, leading to successful identification and validation of STK10 and TNK2 as two novel potential therapeutic targets for Ewing's sarcoma," said Dr. David Azorsa, a TGen Senior Investigator and the paper's senior author.

This was the first study demonstrating the use of this kind of phenotypic profiling to identify unique kinase targets for Ewing's sarcoma, according to the paper.

By identifying kinases that regulate the growth of Ewing's sarcoma cells, TGen investigators anticipate a rapid translation of their discoveries into clinical drug trials and specific remedies for individual patients, advancing the prospects of personalized medicine.

"We undertook this study with the goal of identifying specific kinases that can be targeted to modulate Ewing's sarcoma cell growth and survival," said Dr. Shilpi Arora, a TGen Staff Scientist and the paper's lead author. "In addition to the identification of specific kinase targets, we were able to obtain a better understanding of contextual vulnerabilities in Ewing's sarcoma."


'/>"/>

Contact: Steve Yozwiak
syozwiak@tgen.org
602-343-8704
The Translational Genomics Research Institute
Source:Eurekalert

Related medicine news :

1. Study finds an increased risk of death in men with insomnia and a short sleep duration
2. FDA Finds Rodents, Manure Piles at Farms in Egg Recall
3. Study finds asking about pregnancy coercion and intimate-partner violence can reduce their incidence
4. Location determines social network influence, CCNY-led team finds
5. Herpes Drugs Wont Raise Birth Defect Risk, Study Finds
6. Mumps vaccine coverage should be improved, study finds
7. Survey of American women finds STD vaccine viewed positively
8. Study Finds Even a Little Cigarette Smoke Harms Airway
9. New study finds new connection between yoga and mood
10. Global media campaign finds hidden children with rare, fatal aging disorder
11. VCU Massey research finds new link between inflammation and cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... June 26, 2016 , ... Many ... been diagnosed with endometriosis. These women need a treatment plan to not only ... approach that can help for preservation of fertility and ultimately achieving a pregnancy. ...
(Date:6/25/2016)... ... ... First Choice Emergency Room , the largest network of independent freestanding ... of its new Mesquite-Samuell Farm facility. , “We are pleased to announce Dr. ... James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. , Dr. ...
(Date:6/24/2016)... ... ... A recent article published June 14 on E Online details ... to state that individuals are now more comfortable seeking to undergo not only the ... and cheek reduction. The Los Angeles area medical group, Beverly Hills Physicians (BHP) notes ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Global law firm ... 2016 Legal Elite. The attorneys chosen by their peers for this recognition are considered ... Seven Greenberg Traurig Shareholders received special honors as members of this year’s Legal Elite ...
(Date:6/24/2016)... Norcross, Georgia (PRWEB) , ... June 24, 2016 ... ... Year” awards today at the Clinical Decision Making in Emergency Medicine conference in ... who have authored journal articles published in Emergency Medicine Practice and ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016  Arkis BioSciences, a ... invasive and more durable cerebrospinal fluid treatments, today ... The Series-A funding is led by Innova Memphis, ... and other private investors.  Arkis, new financing will ... and the market release of its in-licensed Endexo® ...
(Date:6/23/2016)...  In a startling report released today, National Safety Council ... a comprehensive, proven plan to eliminate prescription opioid overdoses. ... states are tackling the worst drug crisis in recorded U.S. history, ... Kentucky , New Mexico , ... the 28 failing states, three – Michigan , ...
(Date:6/23/2016)... June 23, 2016 Bracket , a leading ... next generation clinical outcomes platform, Bracket eCOA (SM) 6.0, ... June 26 – 30, 2016 in Philadelphia ... Clinical Outcome Assessment product of its kind to fully integrate ... Bracket eCOA 6.0 is a flexible platform for electronic ...
Breaking Medicine Technology: