Navigation Links
TGen finds therapeutic targets for rare cancer in children

PHOENIX, Ariz. Aug. 31, 2010 The first study of Ewing's sarcoma that screened hundreds of genes based on how they affect cell growth has identified two potential anti-cancer drug targets, according to a scientific paper by the Translational Genomics Research Institute (TGen) published this month in the journal Molecular Cancer.

Ewing's sarcomas are rare, but aggressive cancer lesions that occur most frequently in the bones of teenagers. They represent nearly 3 percent of all childhood cancers. Patients are treated with a combination of surgery, radiation and chemotherapy. This cancer can reoccur after surgical removal, and often spreads to the lungs, other bones and bone marrow. Once it spreads, or metastasizes, only 1 in 5 patients survive more than 5 years.

These lesions harbor unique chromosomal abnormalities that give rise to fusion genes that act as cancer-inducing proteins, or oncoproteins.

TGen researchers used RNAi-based phenotypic, or loss-of-function screening, a method of silencing hundreds of individual genes in a high-throughput format, to analyze 572 kinases that are expressed in human cells. Kinases are enzymes that modify other proteins. Using this technique, the authors discovered two protein kinases with important roles in the growth and survival of Ewing's sarcoma cells. Cancer cells died when investigators stopped the normal function of the two protein kinases called STK10 and TNK2.

"RNAi-based phenotypic profiling proved to be a powerful gene target discovery strategy, leading to successful identification and validation of STK10 and TNK2 as two novel potential therapeutic targets for Ewing's sarcoma," said Dr. David Azorsa, a TGen Senior Investigator and the paper's senior author.

This was the first study demonstrating the use of this kind of phenotypic profiling to identify unique kinase targets for Ewing's sarcoma, according to the paper.

By identifying kinases that regulate the growth of Ewing's sarcoma cells, TGen investigators anticipate a rapid translation of their discoveries into clinical drug trials and specific remedies for individual patients, advancing the prospects of personalized medicine.

"We undertook this study with the goal of identifying specific kinases that can be targeted to modulate Ewing's sarcoma cell growth and survival," said Dr. Shilpi Arora, a TGen Staff Scientist and the paper's lead author. "In addition to the identification of specific kinase targets, we were able to obtain a better understanding of contextual vulnerabilities in Ewing's sarcoma."


Contact: Steve Yozwiak
The Translational Genomics Research Institute

Related medicine news :

1. Study finds an increased risk of death in men with insomnia and a short sleep duration
2. FDA Finds Rodents, Manure Piles at Farms in Egg Recall
3. Study finds asking about pregnancy coercion and intimate-partner violence can reduce their incidence
4. Location determines social network influence, CCNY-led team finds
5. Herpes Drugs Wont Raise Birth Defect Risk, Study Finds
6. Mumps vaccine coverage should be improved, study finds
7. Survey of American women finds STD vaccine viewed positively
8. Study Finds Even a Little Cigarette Smoke Harms Airway
9. New study finds new connection between yoga and mood
10. Global media campaign finds hidden children with rare, fatal aging disorder
11. VCU Massey research finds new link between inflammation and cancer
Post Your Comments:
(Date:11/30/2015)... ... November 30, 2015 , ... ... provider of enterprise Time and Attendance/Workforce Management cloud-based solutions, announced today that ... Program with competencies in the Application Development, demonstrating a “best-in-class” ability and ...
(Date:11/30/2015)... ... November 30, 2015 , ... ... partnership at the Radiological Society of North America (RSNA) 2015 conference. , ... of cutting-edge dictation and speech-enabled documentation software, announced their partnership today at ...
(Date:11/30/2015)... ... November 30, 2015 , ... ... dealer. Joining more than 30 HealthPostures’ dealers located throughout the United States, is ... the number of corporate, industrial, manufacturing and government workers and organizational leaders that ...
(Date:11/30/2015)... ... November 30, 2015 , ... World Patent Marketing ... Swappables, a household invention that provides an economical and easy way of gaining ... is growing at 2.6%," says Scott Cooper, CEO and Creative Director of World ...
(Date:11/30/2015)... ... November 30, 2015 , ... CTI Group (Holdings) Inc. (OTC:CTIG), ... through communication analytics, announced today that their Proteus® VoIP QMS solution now supports ... , Proteus® VoIP QMS (Quality Management System) does this by collecting ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... Wash. , Nov. 30, 2015  Precision ... Post-Processing services, is pleased to announce a dramatic ... medical imaging services. Building on its ISO-9001:2008 certification ... and implemented comprehensive Core Lab protocols and procedures. ... variety of research activities.  Their Core Lab services ...
(Date:11/30/2015)... , November 30, 2015 PFE ... at up to 10 G protein-coupled receptor (GPCR) targets ... to research and develop potential new medicines directed at ... multiple therapeutic areas. --> Heptares Therapeutics ("Heptares"), ... and wholly-owned subsidiary of Sosei Group Corporation ("Sosei"; TSE ...
(Date:11/30/2015)... 30, 2015 Mexico Healthcare and Life Sciences ... Report 2015 . --> Pharmaboardroom releases its new 98-page ... Latin America , a country of over 122 million ... of over 122 million people. --> It offers companies, ... life sciences insights into the second largest pharma and healthcare market ...
Breaking Medicine Technology: