Navigation Links
TGen and Scottsdale Healthcare begin study of new drug for patients with solid tumors
Date:6/17/2014

SCOTTSDALE, Ariz. June 17, 2014 The Virginia G. Piper Cancer Center at Scottsdale Healthcare and the Translational Genomics Research Institute (TGen) are studying the safety and effectiveness of a new drug, AG-120, for treatment of patients with solid tumors, especially those with brain tumors and gallbladder bile duct cancer.

"AG-120 is designed specifically for those patients who carry the IDH1 gene mutation," said Dr. Daniel D. Von Hoff, Distinguished Professor and Physician-In-Chief at TGen, and Chief Scientific Officer for the Virginia G. Piper Cancer Center Clinical Trials at Scottsdale Healthcare, a partnership between Scottsdale Healthcare and TGen that delivers new treatments to cancer patients based on precision medicine.

The IDH1 gene mutation is most commonly found in gliomas, which make up the largest group of "primary" brain tumors, those that start in the brain. Gliomas include all tumors arising from the gluey or supportive tissue of the brain. They represent about 30 percent of all brain tumors, and about 80 percent of all malignant brain tumors.

As with all brain cancers, gliomas are difficult to treat and many grow back after surgery, radiation and standard of care chemotherapy. Many drugs cannot get to the brain because of a filtering mechanism in the body called the blood-brain barrier.

"There is a great need for more effective treatments for patients with gliomas and other solid tumors, such as gallbladder bile duct cancer," said Dr. Von Hoff, who is the Principal Investigator for AG-120 clinical trial. This study will enroll as many as 50 patients. Researchers will use precision medicine to match treatments to patient's specific genomic, or molecular, makeups.

Mutations in isocitrate dehydrogenase (IDH) 1 and 2, originally discovered in 2008, occur in the vast majority of low-grade gliomas and secondary high-grade gliomas. IDH mutations are oncogenic, meaning they have the potential to cause
'/>"/>

Contact: Steve Yozwiak
syozwiak@tgen.org
602-343-8704
The Translational Genomics Research Institute
Source:Eurekalert

Page: 1 2

Related medicine news :

1. TGen and Scottsdale Healthcare cancer expert Dr. Von Hoff receives Hope Funds award
2. TGen and Scottsdale Healthcare cancer expert Dr. Daniel D. Von Hoff is honored by ASCO
3. Scottsdale Treatment Center Launches Program to Address Illicit Drug Use in Adults, Adolescents
4. Home Care Assistance of Scottsdale Launches New Website
5. Luxury Arizona Condos from The Statesman Group are Now Available for Purchase in Scottsdale/Phoenix, Arizona
6. Top Phoenix Hearing Aid Provider Opens New Office in Scottsdale, AZ
7. Younan Properties Announces Successful Financing of Scottsdale Shopping Center; Retail Promenade to be Renamed 7 Thousand Shea
8. Alice Branton Invites the Eyes of the World to Focus on Scottsdale, Arizona
9. Arizona Marijuana Doctor Helps Scottsdale Patients Achieve Green Wellness in the Copper State
10. Mahendra Kumar Trivedi to Host Retreat in Scottsdale, Arizona
11. TGen-TD2-Scottsdale Healthcare breast cancer pilot study shows value of proteomic mapping
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... Princeton, Indiana (PRWEB) August 22, 2014 ... because Toyota Indiana is on the grow ... add 300 jobs by summer 2016 to boost production ... expansion will bring Toyota Indiana’s overall investment to $4 ... in North America while providing additional flexibility to adjust ...
(Date:8/22/2014)... Medicine team has found that targeted automated alerts ... infections in hospital patients with urinary catheters. In ... simplified, the rate of improvement dramatically increased. , ... need urinary catheters in the first place and ... catheters that have not been removed within a ...
(Date:8/22/2014)... Americans know little about how Ebola is transmitted and harbor ... United States, a new survey shows. About four in ... a major Ebola outbreak in the United States, and one-quarter ... get sick with the deadly virus in the next year, ... However, those opinions don,t match reality, the Harvard researchers ...
(Date:8/22/2014)... Worth, FL (PRWEB) August 22, 2014 ... addiction treatment facility in Lantana, FL, recently launched ... those just looking for information can now find ... Millennium’s new website just went live at the ... know about the facility can be found on ...
(Date:8/22/2014)... 2014 Beat Eczema , Susan ... use natural methods to completely cure the eczema symptoms ... of Shane Michaels, prompting an investigative review. , ... skin, it can still be extremely debilitating and life-altering ... intense itching and pain that it causes on the ...
Breaking Medicine News(10 mins):Health News:Toyota Indiana Adding 300 Jobs to Build More Highlanders 2Health News:Penn study: Electronic alerts significantly reduce catheter-associated urinary tract infections 2Health News:Penn study: Electronic alerts significantly reduce catheter-associated urinary tract infections 3Health News:Many Americans Harbor Unfounded Fears About Ebola Outbreak: Survey 2Health News:Millennium Treatment Group Has a New Website 2Health News:Beat Eczema: Review Exposes Susan Clark’s Guide to Curing Eczema Naturally 2
... annually in Thailand is an ongoing challenge for ... to Somchai Pinyopornpaitch, deputy director-general of the Department ... several years despite health officials' efforts. TB incidence ... with 90,000 new cases annually, and the treatment ...
... the go-ahead to the new cosmetic filler, Radiesse, to ... in patients with AIDS or HIV. This calcium based ... collagen. ,To ascertain the potential benefits of ... HIV patients suffering facial lipoatrophy. The patients were given ...
... ‘Mindfulness’ is now being taught to Queensland women with eating ... women who struggle with binge eating and bulimia. It is ... emotions that trigger their binges. ,Unlike many ... and controlling eating and more on providing freedom from negative ...
... as a simple equation; more guns, more murders. ... Harvard School of Public Health came out with results of ... firearms is a hot topic in US, where the case ... three US households owns a gun,according to current data. ...
... on the surprise findings of a study appearing in the ... that scientists have discovered histamine,// the inflammatory compound released during ... ,They say that histamine can be produced ... Blood Cells (WBC) that is the major component of pus. ...
... box that is where most of our chores end up in. ... tried to makes sense out// of why we procrastinate, in a ... study took ten years instead of five, Steel has put up ... (U) = Expectation of Success (E) x Value of Completion (V) ...
Cached Medicine News:Health News:WBC in Lung Produces Histamine: Study 2Health News:WBC in Lung Produces Histamine: Study 3Health News:Read This Now Not Later! 2
(Date:8/21/2014)... DEERFIELD, Ill. , Aug. 21, 2014 /PRNewswire/ ... reports Baxter International Inc. today announced positive results ... BAX 855, an investigational, extended half-life recombinant factor ... ADVATE [Antihemophilic Factor (Recombinant)], which met its primary ... the prophylaxis arm compared to the on-demand arm. ...
(Date:8/21/2014)... Canadian Epilepsy Alliance (CEA) is thrilled to announce the launch ... the most common neurological disorder in Canada ... tells a fictional story based on the experiences of 14-year-old ... "Despite the fact that epilepsy affects 1 ... lack of awareness out there," says Gail Dempsey , ...
(Date:8/21/2014)... -- Seventy-one percent of Americans believe the abuse of strong prescription ... and safety issue in the United States ... Repass & Partners, a Cincinnati based ... of the prescription medication abuse problem and the need for ... situation facing our country," Rex Repass , CEO of ...
Breaking Medicine Technology:Baxter Announces Positive Top-Line Results from Its Phase 3 Study of BAX 855, Extended Half-Life Recombinant FVIII for Hemophilia A Patients 2Baxter Announces Positive Top-Line Results from Its Phase 3 Study of BAX 855, Extended Half-Life Recombinant FVIII for Hemophilia A Patients 3Baxter Announces Positive Top-Line Results from Its Phase 3 Study of BAX 855, Extended Half-Life Recombinant FVIII for Hemophilia A Patients 4Baxter Announces Positive Top-Line Results from Its Phase 3 Study of BAX 855, Extended Half-Life Recombinant FVIII for Hemophilia A Patients 5Action Heroes Harness Powers to Educate Children About Epilepsy 2Action Heroes Harness Powers to Educate Children About Epilepsy 3Consumers Desperate For Measures To Curb Prescription Drug Abuse 2Consumers Desperate For Measures To Curb Prescription Drug Abuse 3
... (Nasdaq: CADX ) today announced that it has ... common stock at a price to the public of $3.75 ... shares, after deducting the underwriting discounts and commissions and estimated ... has granted the underwriters for the offering a 30-day option ...
... 15, 2011 Reportlinker.com announces that a ... its catalogue: The Outlook ... http://www.reportlinker.com/p0617406/The-Outlook-for-Pharmaceuticals-in-North-East-Asia ... pharmaceutical markets that present immense potential for ...
Cached Medicine Technology:Cadence Pharmaceuticals Announces Pricing of Public Offering of Common Stock 2Cadence Pharmaceuticals Announces Pricing of Public Offering of Common Stock 3The Outlook for Pharmaceuticals in North East Asia 2The Outlook for Pharmaceuticals in North East Asia 3The Outlook for Pharmaceuticals in North East Asia 4
... utilize Linvatecs exclusive Shockflex prism system to ... Using the latest technology, our 3CCD Camera ... and brightness. The Camera Heads are available ... configured with a number of optical couplers ...
... an integrated coupler can be steam sterilized using ... it is cool to the touch and ready ... Smarthead technology allowing each head to store procedure ... head has been used is displayed on the ...
... invasive surgery is founded on superior medical ... of 3-Chip cameras, 1-Chip cameras, Light sources, ... your demanding needs., ,Superior resolution and ... our 3-Chip cameras, and are the benchmark ...
... high-resolution 1-Chip Camera System provides easy-to-use features, ... small scope. The camera head construction is ... ,Complete 1-Chip Camera System for Microscopic Application, ... Camera Control Unit (CCU) with power cord ...
Medicine Products: