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TGen analysis identifies biomarkers for diabetic kidney failure
Date:12/30/2009

ic DNA from more than 500 cases of those with ESRD and compared that to more than 500 patients who had Type I diabetes for at least 20 years with no sign of ESRD. Scientists performed a whole genome association scan to look for single nucleotide polymorphisms (SNPs), which are the individual letters of DNA that vary among individuals. They sought SNPs that indicate a susceptibility to ESRD.

Experiments identified at least eight locations along the nearly 3-billion-base human genome that are ripe for further investigation of their ties to ESRD, according to the paper, Genome-wide SNP genotyping study using pooled DNA to identify candidate markers mediating susceptibility to end-stage renal disease attributed to Type 1 diabetes.

The study found at least six markers that may be associated with Type 1 diabetes, a lifelong disease that occurs when the pancreas does not produce enough insulin to properly control blood-sugar levels. There currently is no way to prevent Type 1, which is caused by autoimmune, genetic or environmental factors.

The study found two markers that may be associated with Type 2 diabetes, the most common form of diabetes. Type 2 develops when the body fails to produce enough insulin, which helps turn glucose from the sugars and starches we eat into energy. The failure to process glucose starves cells of energy and over time can damage the eyes, nerves, heart or kidneys. Type 2 diabetes can be prevented or treated with proper diet and exercise.

Using a similar pooled DNA analysis, TGen researchers, working with collaborators at the University of California Los Angeles, last year developed a way to identify an individual's DNA from among a mixture of DNA of hundreds or even thousands of individuals.

"This technique will increasingly be used in identifying the genetic origins of many Types of disease,'' predicted Dr. David Craig, Associate Director of TGen's Neurogenomics Division, who co-developed the tech
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Contact: Steve Yozwiak
syozwiak@tgen.org
602-343-8704
The Translational Genomics Research Institute
Source:Eurekalert

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