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TGen analysis identifies biomarkers for diabetic kidney failure
Date:12/30/2009

PHOENIX, Ariz. Dec. 16, 2009 Researchers using a DNA analysis tool developed by the Translational Genomics Research Institute (TGen) and UCLA have identified genetic markers that could help treat chronic kidney disease among diabetics.

Study results, published in the December edition of Diabetic Medicine, show it is possible to identify biomarkers associated with end-stage renal disease (ESRD) from the pooled DNA of more than 1,000 diabetics. Specifically, TGen researchers identified genes that could potentially contribute to ESRD among those with Type 1 Diabetes.

ESRD almost always follows chronic kidney failure and although treatable with dialysis or transplantation, mortality rates remain high. While diabetic kidney disease is one of the most common complications of diabetes, it is currently not possible to determine who is at risk for ESRD.

"Identification of specific DNA variants may enhance our understanding of genetic risk factors for renal disease and may provide diagnostic value in determining which patients are at greatest risk of developing ESRD," said Dr. Johanna DiStefano, Director of TGen's Diabetes, Cardiovascular & Metabolic Diseases Division and the paper's senior author.

The need to rapidly identify individuals with a predisposition to ESRD and to discover new drugs to prevent and treat this devastating condition is becoming critical, as the average onset of this disease affects ever-younger populations. Although Type 1 diabetes is distinctly different from Type 2 diabetes, the development of kidney disease is similar in individuals with either form. Researchers expect the current findings to impact individuals with both forms of the disease.

Nearly 23 percent of Americans diagnosed with ESRD die within the first year. And the annual cost for the nearly 400,000 people who require blood dialysis or kidney transplants is more than $16 billion.

TGen researchers tested the pooled genom
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Contact: Steve Yozwiak
syozwiak@tgen.org
602-343-8704
The Translational Genomics Research Institute
Source:Eurekalert

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