Navigation Links
TGen, Scottsdale Healthcare lead worldwide study of new drug for patients with pancreatic cancer

SCOTTSDALE, Ariz. A new cancer drug combination demonstrated significant improvement in overall survival of late-stage pancreatic cancer patients compared to those receiving standard treatment, according to results of a Phase III clinical trial led by physicians from Scottsdale Healthcare's Virginia G. Cancer Center Clinical Trials, a partnership with the Translational Genomics Research Institute (TGen).

Physicians at the Virginia G. Piper Cancer Center at Scottsdale Healthcare were first to design a clinical trial to determine the safety, tolerability and effectiveness of nab-paclitaxel (Abraxane) in combination with the standard drug gemcitabine in patients with advanced pancreatic cancer. Results of that multicenter study chaired by Dr. Daniel Von Hoff were encouraging enough that it led to one of the largest international studies ever done in pancreatic cancer, with 861 patients.

Full results are expected to be presented at the American Society of Clinical Oncology (ASCO) 2013 Gastrointestinal Cancers Symposium in Jan. 24-26 in San Francisco.

"This is a great example of rapid bench to bedside development of new treatments for cancer. We're ecstatic that we will have a new treatment for patients with late stage pancreatic cancer," said Dr. Von Hoff, international lead investigator and Chief Scientific Officer for the Virginia G. Cancer Center Clinical Trials at Scottsdale Healthcare and TGen's Physician-In-Chief.

The pancreas is a gland behind the stomach that secretes enzymes into the upper part of the small intestine to help digestion. It also produces hormones, including insulin, which helps regulate the metabolism of sugars. Advanced pancreatic cancer is fourth most common cause of cancer death in the United States and throughout the world. It is a difficult to diagnose and treat cancer with the lowest survival rates among all cancer types.

Nab-paclitaxel (Abraxane) is an albumin-bound formulation of paclitaxel, produced by Celgene Corp. Dr. Von Hoff said that results of the MPACT (Metastatic Pancreatic Adenocarcinoma Clinical Trial) study will lead Celgene to submit for FDA approval.

"Pancreatic cancer incidence is increasing worldwide with almost 220,000 cases per year, and we are optimistic that this will have worldwide impact for treating advanced pancreatic cancer," added Dr. Ramesh Ramanathan, Medical Director of Virginia G. Cancer Center Clinical Trials at Scottsdale Healthcare and principal investigator for the United States.

Dr. Von Hoff credited the support of Scottsdale Healthcare Foundation, Stand Up to Cancer and the Seena Magowitz Foundation for advancing the study at the Virginia G. Piper Cancer Center at Scottsdale Healthcare. He noted that TGen and International Genomics Consortium scientists in collaboration with scientists from Abraxis Bioscience found that in pancreatic cancer, an albumin-binding protein called SPARC was present at high levels in cells within the pancreatic tumor microenvironment. They hypothesized that the albumin formulation of nab-paclitaxel may be taken up by tumor and surrounding cells with high SPARC expression.

Contact: Steve Yozwiak
The Translational Genomics Research Institute

Related medicine news :

1. New TGen, Virginia G. Piper Cancer Center study targets non-small cell lung cancer
2. Social environmental factors affect rehospitalization risk in home healthcare patients
3. Kessler Foundation stroke expert receives $145,000 grant from Healthcare Foundation of New Jersey
4. Healthcare ethics consultants share lessons learned
5. Health inequalities could be reduced by more effective healthcare, says new study
6. Daily disinfection of isolation rooms reduces contamination of healthcare workers hands
7. Healthcare researchers recognized at SingHealth Duke-NUS Scientific Congress 2012
8. Coral Calcium Company Announces New Offer Amidst Supreme Court Healthcare Decisions
9. Weill Cornell Medical College establishes Center for Healthcare Informatics and Policy
10. Saving brains in developing countries: $11.8 million for innovative ideas worldwide
11. Ageism presents dilemmas for policymakers worldwide
Post Your Comments:
(Date:11/30/2015)... Los Angeles, CA (PRWEB) , ... November 30, 2015 , ... ... music star Jessie James Decker made a brave but slightly unusual choice to show ... quickly returning to her pre-pregnancy form may have been pre-mature. Saying that she didn’t ...
(Date:11/30/2015)... ... November 30, 2015 , ... A record crowd gathered at the Pennsylvania Biotech ... the Baruch S. Blumberg Institute. , The institute, which is the research arm of ... biotechnology leaders for the conference, which focused on ways companies can work to reduce ...
(Date:11/30/2015)... Scotch Plains, NJ (PRWEB) , ... November 30, 2015 , ... ... patients in a comfortable and convenient setting. , When you have dental problems, you ... knows the field and can effectively diagnose and treat your needs, a friendly dentist ...
(Date:11/30/2015)... Scotch Plains, NJ (PRWEB) , ... November 30, 2015 , ... ... third generation dentist. His grandfather graduated from Tufts School of Dental Medicine in ... celebrates 80 years for the Isola family being in dentistry as well as their ...
(Date:11/30/2015)... ... November 30, 2015 , ... The Foundation ... cancer education and prevention—is joining forces with the award-winning creator and writer of ... on December 7, 2015 at the Union League of Philadelphia. , The ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... VIEW, Calif. , Nov. 30, 2015 ... been the norm in U.S. medical imaging ... The increasingly popular accountable care payer-provider contracts ... models and, in their wake, alter provider-vendor ... quality-based payments will push forward new purchasing ...
(Date:11/30/2015)... and SAN DIEGO , ... Pharmaceuticals, Inc. (NASDAQ: ARNA ) today announced that ... for filing the New Drug Application (NDA) for an ... release formulation will offer patients a chronic weight management ... ® ) is currently approved as an adjunct to ...
(Date:11/30/2015)... and ST. LOUIS , Nov. 30, ... ESRX ) today announced an early renewal of ... began in 1999, will now extend through at least ... After evaluating pharmacy benefit manager capabilities during a ... Scripts continues to offer the best health plan integration ...
Breaking Medicine Technology: