Navigation Links
TG02 Potently Inhibits the Proliferation and Survival of Multiple Myeloma Cell Lines through Depletion of the Key Survival Protein MCL-1
Date:4/5/2013

San Diego (PRWEB) April 05, 2013

Tragara Pharmaceuticals, Inc. today announced that profiling biological data on TG02, the Company's unique oral kinase inhibitor, has been published in Clinical Cancer Research. Researchers from the Instituto de Biologia Molecular y Celular del Cancer, University of Salamanca, utilized in vivo models and patient-derived ex vivo samples to evaluate the antitumor activity and mechanism of action of TG02 in multiple myeloma. The data show that TG02 potently and consistently inhibited proliferation and survival of multiple myeloma cell lines, even under protective bone marrow niche conditions, and selectively induced apoptosis of primary patient-derived malignant plasma cells. The study also reported that that TG02 induced robust activation of the intrinsic pathways of apoptosis via its ability to deplete the key survival protein Mcl-1.

In this study, TG02 displayed significant single agent activity in two multiple myeloma xenograft models. Additionally, TG02 enhanced the in vivo activity of bortezomib and lenalidomide, two currently approved treatments for myeloma. As most of the treatment regimens for myeloma patients are based upon drug combinations, TG02’s demonstrated ability to augment the antitumor activity of other agents is a clinically important observation. The researchers also reported that the studied TG02 combinations were well tolerated by the animals.

TG02 is currently in phase I clinical testing in patients with multiple myeloma in the United States. An additional phase I clinical study in patients with chronic lymphocytic leukemia is also underway and a phase I study in acute leukemia has been completed.

1. Álvarez-Fernández, Stela, et al. "Potent antimyeloma activity of a novel ERK5/CDK inhibitor." Clinical Cancer Research (2013).

About TG02
TG02 is a unique, oral multi-kinase inhibitor which combines the benefits
'/>"/>

Source: PRWeb
Copyright©2012 Vocus, Inc.
All rights reserved

Page: 1 2 3

Related medicine news :

1. Bloodstream scavenger inhibits clotting without increased bleeding
2. Molecule found that inhibits recovery from stroke
3. New monoclonal antibody inhibits tumor growth in advanced solid tumors in phase I clinical trial
4. Kentucky team inhibits Alzheimers biomarkers in animal model by targeting astrocytes
5. CWRU School of Medicine researchers discover gene that permanently stops cancer cell proliferation
6. Vaccine yielded encouraging long-term survival rates in certain patients with NSCLC
7. Cancer Care Costs Higher in U.S. Than Europe, But Survival Longer
8. Adding drug to standard chemotherapy provides no survival benefit for older lung cancer patients
9. Hispanics Seem to Have Better Odds of Lung Cancer Survival
10. Equal access to care helps close survival gap for young African-American cancer patients
11. Heart Attack Survival Varies Widely Among Hospitals, Study Finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/29/2014)... Daily Gossip indicates in its Natural Cure for Yeast Infection ... who is looking for an all-natural holistic cure for this ... Sarah Summer, says that her method is 100 percent natural. ... this is the reason why she was so determined in ... Natural Cure for Yeast Infection review indicates that Sarah ...
(Date:7/29/2014)... (PRWEB) July 29, 2014 For numerous women ... a relationship work can turn out being quite hard. Well, ... that he discovered the method that can help all these ... to make a guy show love and attention every day. ... revolutionary method was actually created by Alex Carter who published ...
(Date:7/29/2014)... July 30, 2014 Recent international ... devices have determined Nurse Call Systems to be ... this requires all Nurse Call Systems to be ... improves patient safety, reduces clinical risks, and is ... based Corporate Risk and Clinical Risk Committee actively ...
(Date:7/29/2014)... Denver, Colorado (PRWEB) July 29, 2014 Daily ... is a 5 step holistic system that will permanently eliminate ... to Thomas Coleman his natural treatment will banish symptoms such ... ringing or beeping sound heard by patients will be gone ... 30 to 60 days. The author of this program says ...
(Date:7/29/2014)... 2014 Daily Gossip indicates in its Acne ... to gain beautiful and clear skin in just 30 to ... these positive results even sooner than that. The new method ... used this step by step program, too. , Mike ... years. Mike battled this condition for a decade and none ...
Breaking Medicine News(10 mins):Health News:Natural Cure for Yeast Infection Review Reveals Sarah Summer’s Healing Method 2Health News:"Make Him Desire You" Review Reveals Unique Formula to Make Men Feel a Special Kind of Love 2Health News:NiQ Health Reveals the Extensive Use of Unregulated Medical Devices in Australian Hospitals 2Health News:NiQ Health Reveals the Extensive Use of Unregulated Medical Devices in Australian Hospitals 3Health News:NiQ Health Reveals the Extensive Use of Unregulated Medical Devices in Australian Hospitals 4Health News:Tinnitus Miracle Review Exposes the Only Holistic System for Tinnitus Cure 2Health News:Acne No More Review Reveals Most Effective Acne Cure Program 2
... Hospital and Columbia University Medical Center has led the ... HIV.// He is lead author and chair of the ... treatment of the disease in developed nations—presented on Aug. ... and published in the Aug. 16 Journal of the ...
... scientists childhood allergies are increasing around the world, even ... eczema have become serious// public health issues. ... being hospitalized or even dying. ,Although the ... inflammation of the airways, it is still unknown what ...
... maternity hospital was diagnosed with deadly whooping cough. As a ... as a precautionary measure. ,This woman was working ... in Camperdown. The Sydney South West Area Health Service had ... staff member ceased all contact with patients and families immediately,' ...
... epidemic of this season. This disease seems to have overshadowed ... the viral disease had been reported from Tamil Nadu, Karnataka, ... last 2 years. In Tamil Nadu alone, 49,567 people have ... · Aedes aegypti mosquito is 60 % higher than ...
... not to give unpasteurized apple juice or other unpasteurized products ... Even the elderly and people with weak immune systems are ... is that such products contain Salmonella and E. coli, which ... also said that a majority of juice n the country ...
... project that will test the clinical efficacy of Ayurvastra, ... herb// concoctions." The project was launched at the Government ... project was started by the Directorate of Handloom, Department ... Vijnan, Government Ayurveda College. The project aims to start ...
Cached Medicine News:Health News:Dr. Scott Hammer Authors Two New Guidelines for HIV Treatment 2Health News:World wide Increase in Childhood Allergies 2Health News:Beware of Chikungunya !! 2
(Date:7/29/2014)... July 29, 2014  Synthetic Biologics, Inc. (NYSE MKT: ... candidates targeting specific pathogens that cause serious infections and ... market activity in the Company,s stock, the NYSE MKT ... its usual practice. The Company stated that its policy ... About Synthetic Biologics, Inc. Synthetic Biologics, ...
(Date:7/29/2014)... July 29, 2014 Numotion,s Board of Directors has ... will be the company,s new Chief Executive Officer. ... career at GE where he worked primarily for GE Healthcare ... to over $5 billion. His most recent position was as ... "I am thrilled to join Numotion," said Mike ...
(Date:7/29/2014)... New York , July 29, 2014 ... by Transparency Market Research "Orthopedic Trauma Fixation Devices Market ... Analysis 2014 - 2020", the global orthopedic trauma fixation ... 2014 and is expected to grow at a CAGR ... estimated value of USD 9.3 billion in 2020. ...
Breaking Medicine Technology:Synthetic Biologics, Inc. States that Its Policy is Not to Comment on Unusual Market Activity 2Numotion Names Mike Swinford CEO 2Orthopedic Trauma Fixation Devices Market is Expected to Reach USD 9.3 Billion Globally in 2020: Transparency Market Research 2Orthopedic Trauma Fixation Devices Market is Expected to Reach USD 9.3 Billion Globally in 2020: Transparency Market Research 3Orthopedic Trauma Fixation Devices Market is Expected to Reach USD 9.3 Billion Globally in 2020: Transparency Market Research 4
... 2011 Halozyme Therapeutics, Inc. (Nasdaq: HALO ... the extracellular matrix , today announced it plans ... May 6, 2011 before the open of the financial ... call with the investment community at 8:00 a.m. PDT ...
... 2011 Pharmacyclics, Inc. (NASDAQ: PCYC ), ... commercializing innovative small molecule drugs for the treatment of ... management will host a conference call and live audio ... to discuss the company,s third quarter fiscal 2011 financial ...
Cached Medicine Technology:Halozyme Therapeutics to Host First Quarter 2011 Financial Results Conference Call on May 6 2Pharmacyclics to Announce Third Quarter Fiscal 2011 Results and Host a Conference Call on May 4, 2011 2
Featuring a secure and tamper-evident adhesive closure, computer-generated Smart ScanBand can be simultaneously printed with bar code information and programmed with RFID information....
... System helps protect infants, patients, staff, and ... efficiencies, cost savings, and overall peace of ... constrained healthcare facilities., And with HALO, youre ... versatile solution, but also unique-skin sensing RFID ...
VerdaSee Dock Door Portal ID solutions provide high performance tracking of assets that enter or leave healthcare facilities through dock doors....
VerdaSee Portal ID is a family of solutions that provide automated tracking and tracing of assets as they enter or leave designated areas within a healthcare facility....
Medicine Products: