Navigation Links
TG02 Potently Inhibits the Proliferation and Survival of Multiple Myeloma Cell Lines through Depletion of the Key Survival Protein MCL-1
Date:4/5/2013

San Diego (PRWEB) April 05, 2013

Tragara Pharmaceuticals, Inc. today announced that profiling biological data on TG02, the Company's unique oral kinase inhibitor, has been published in Clinical Cancer Research. Researchers from the Instituto de Biologia Molecular y Celular del Cancer, University of Salamanca, utilized in vivo models and patient-derived ex vivo samples to evaluate the antitumor activity and mechanism of action of TG02 in multiple myeloma. The data show that TG02 potently and consistently inhibited proliferation and survival of multiple myeloma cell lines, even under protective bone marrow niche conditions, and selectively induced apoptosis of primary patient-derived malignant plasma cells. The study also reported that that TG02 induced robust activation of the intrinsic pathways of apoptosis via its ability to deplete the key survival protein Mcl-1.

In this study, TG02 displayed significant single agent activity in two multiple myeloma xenograft models. Additionally, TG02 enhanced the in vivo activity of bortezomib and lenalidomide, two currently approved treatments for myeloma. As most of the treatment regimens for myeloma patients are based upon drug combinations, TG02’s demonstrated ability to augment the antitumor activity of other agents is a clinically important observation. The researchers also reported that the studied TG02 combinations were well tolerated by the animals.

TG02 is currently in phase I clinical testing in patients with multiple myeloma in the United States. An additional phase I clinical study in patients with chronic lymphocytic leukemia is also underway and a phase I study in acute leukemia has been completed.

1. Álvarez-Fernández, Stela, et al. "Potent antimyeloma activity of a novel ERK5/CDK inhibitor." Clinical Cancer Research (2013).

About TG02
TG02 is a unique, oral multi-kinase inhibitor which combines the benefits
'/>"/>

Source: PRWeb
Copyright©2012 Vocus, Inc.
All rights reserved

Page: 1 2 3

Related medicine news :

1. Bloodstream scavenger inhibits clotting without increased bleeding
2. Molecule found that inhibits recovery from stroke
3. New monoclonal antibody inhibits tumor growth in advanced solid tumors in phase I clinical trial
4. Kentucky team inhibits Alzheimers biomarkers in animal model by targeting astrocytes
5. CWRU School of Medicine researchers discover gene that permanently stops cancer cell proliferation
6. Vaccine yielded encouraging long-term survival rates in certain patients with NSCLC
7. Cancer Care Costs Higher in U.S. Than Europe, But Survival Longer
8. Adding drug to standard chemotherapy provides no survival benefit for older lung cancer patients
9. Hispanics Seem to Have Better Odds of Lung Cancer Survival
10. Equal access to care helps close survival gap for young African-American cancer patients
11. Heart Attack Survival Varies Widely Among Hospitals, Study Finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/17/2014)... 17, 2014 Final Cut Pro X plugin ... 5k from Pixel Film Studios. , “ProBlue 5k is a ... from good to epic,” said Christina Austin, CEO of Pixel ... 5k is a definite game changer.” , ProBlue 5k is ... any filmmaker ! This footage compilation of over 100 ...
(Date:9/17/2014)... September 17, 2014 People who struggle to ... head to http://www.perwickstrom.com and get the answer by ... to point out, is that a business plan and a ... work together, commented Per Wickstrom. “The way I view it ... a business strategy which is part two.” , According ...
(Date:9/17/2014)... Chicago IL (PRWEB) September 17, 2014 ... of Pseudomonas aeruginosa infections allegedly caused by Non-Sterile ... to learn more about their options for legal recourse. ... & Drug Administration (FDA) in March 2012, after the ... Pseudomonas aeruginosa at William Beaumont Hospital in Royal Oak, ...
(Date:9/17/2014)... HealthDay Reporter WEDNESDAY, Sept. ... to household chemicals known as phthalates might increase a ... reported in a new study. Children had nearly ... age 5 and 11 if their mothers were exposed ... thal-ates), the researchers found. The two phthalates were butylbenzyl ...
(Date:9/17/2014)... Texas (PRWEB) September 17, 2014 Prevention ... outbreak that is hospitalizing scores of infants, children and ... says Dr. Kirk Mahon, medical director of Legacy ER ... “There have been no reported cases of EV-D68 so ... and Louisiana, that could change,” he said. “Implementing prevention ...
Breaking Medicine News(10 mins):Health News:A New Plugin Entitled ProBlue 5k Was Released Today from Pixel Film Studios Exclusively for Final Cut Pro X 2Health News:Per Wickstrom’s Latest Blog Explores the Difference Between a Business Plan and a Business Strategy 2Health News:Victims of Pseudomonas Infections Allegedly Caused by Other-Sonic Ultrasound Transmission Gel Face Statute of Limitations, Reports The Oliver Law Group P.C. 2Health News:Victims of Pseudomonas Infections Allegedly Caused by Other-Sonic Ultrasound Transmission Gel Face Statute of Limitations, Reports The Oliver Law Group P.C. 3Health News:Victims of Pseudomonas Infections Allegedly Caused by Other-Sonic Ultrasound Transmission Gel Face Statute of Limitations, Reports The Oliver Law Group P.C. 4Health News:Prenatal Exposure to Chemicals in Plastics Linked to Asthma Risk in Kids 2Health News:Prenatal Exposure to Chemicals in Plastics Linked to Asthma Risk in Kids 3Health News:Prenatal Exposure to Chemicals in Plastics Linked to Asthma Risk in Kids 4Health News:Legacy ER & Urgent Care Warns North Texans about Dangers of Enterovirus D68 2
... ... ... , , ... ...
... , ... plans to address neighborhood concerns. , ... South Boston, MA (PRWEB) March 1, 2010 -- Fenway Bark today announced operational changes ... before the City of Boston Zoning Board of Appeal, to request an Interim Planning Overlay ...
... ... ... ... ...
... , ... ... ... ...
... ... , ... , , , ... MCKINNEY, ...
... ... , ... , , , , ... ...
Cached Medicine News:Health News:Northstar Management Forecasts a Loss of $1.2 Million for 2010 at Its Palladium for Surgery -- Houston, Ltd. Centre 2Health News:Dog Owners and Southie Residents Welcome Fenway Bark Into the Pack 2Health News:Dog Owners and Southie Residents Welcome Fenway Bark Into the Pack 3Health News:Tips for Safe Charitable Giving in Response to Earthquakes in Chile and Haiti 2Health News:Tips for Safe Charitable Giving in Response to Earthquakes in Chile and Haiti 3Health News:Tips for Safe Charitable Giving in Response to Earthquakes in Chile and Haiti 4Health News:Tips for Safe Charitable Giving in Response to Earthquakes in Chile and Haiti 5Health News:Tips for Safe Charitable Giving in Response to Earthquakes in Chile and Haiti 6Health News:AMA: Physicians Outraged at Today's Steep Medicare Cut 2Health News:AMA: Physicians Outraged at Today's Steep Medicare Cut 3Health News:AMA: Physicians Outraged at Today's Steep Medicare Cut 4Health News:AMA: Physicians Outraged at Today's Steep Medicare Cut 5Health News:AMA: Physicians Outraged at Today's Steep Medicare Cut 6Health News:AMA: Physicians Outraged at Today's Steep Medicare Cut 7Health News:Torchmark Corporation Declares Dividend and Resumes Stock Repurchases 2Health News:MedCath Corporation Announces Decision to Consider Strategic Options 2
(Date:9/17/2014)... 2014 BRIC Gynecological Devices Market Outlook ... GlobalData,s new report, "BRIC Gynecological Devices Market Outlook ... BRIC Gynecological Devices market. The report provides value, ... and average prices (in US dollars) within market ... (Micro-inserts) and Mechanical Sterilization Devices (Tubal Clips and ...
(Date:9/17/2014)... 17, 2014 The ambulance equipment ... decade due to the recession, an unstable ... advancements. This BCC Research report analyzes present ... the ambulance and emergency medical services equipment ... hemorrhage control devices, equipment used for burn ...
(Date:9/17/2014)... Pomerantz LLP is investigating claims on behalf ... the "Company") (NASDAQ: PDLI).  Such investors are advised to ... or 888-476-6529, ext. 237. The investigation ... and/or directors have violated Sections 10(b) and 20(a) of ... On September 17, 2014, the Company announced that On ...
Breaking Medicine Technology:BRIC Gynecological Devices Market Outlook to 2020 2BRIC Gynecological Devices Market Outlook to 2020 3Ambulance and Emergency Equipment: Global Markets 2Ambulance and Emergency Equipment: Global Markets 3Ambulance and Emergency Equipment: Global Markets 4SHAREHOLDER ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of PDL BioPharma, Inc. - PDLI 2
... 2012 Synteract , Inc., a full-service contract ... developing new therapies to combat the growing issue of ... Great Strides fundraising walk to benefit the Cystic ... Rempex (on behalf of Aptalis Pharma) are also working ...
... Ind., May 2, 2012  Hill-Rom Holdings, Inc. (NYSE: ... declared a fiscal year 2012 third quarter dividend of $0.125 ... to shareholders of record as of the close of business ... HOLDINGS, INC. Hill-Rom is a leading worldwide manufacturer ...
Cached Medicine Technology:Synteract and Rempex Partner in "Great Strides" Walk to Support Cystic Fibrosis Cure 2
5 mm tying platform. Round knurled handle with dull finish. Curved shafts. Overall length 3.9 inches....
Straight shafts and tips with 5.5 mm tying platform. 0.3 mm gap at platform heel. True round knurled handle in closed position with polished finish. Overall length 4.3 inches....
Curved shafts with 12 mm tying platform. Serrated handle with polished finish. Overall length 4.3 inches....
Hartman Mosquito forceps, straight, 3-1/2", German stainless steel...
Medicine Products: