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TB lung infection causes changes in the diversity of gut bacteria in mice
Date:5/13/2014

ided with the most active immune response, we believe that it was the mucosal immune system that caused the shift in diversity."

Very little is known about the effects of specific gut microorganisms in humans, according to Winglee. So finding that there is a significant loss of diversity of gut bacteria with TB infection is a critical step in understanding some of the events that occur during this disease, as well as the role of the mucosal immune system, she says.

"We often think of each part of the mucosal immune system, such as the lungs and gut, to be separated," Winglee notes. "However, the fact that an aerosol infection causes such rapid changes in the gut suggests that the various parts of the mucosal system throughout the body actually function in some way like a single organ."


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Contact: Stephanie Desmon
sdesmon1@jhmi.edu
410-955-8665
Johns Hopkins Medicine
Source:Eurekalert

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