Navigation Links
TB breakthrough could lead to stronger vaccine
Date:3/3/2009

A breakthrough strategy to improve the effectiveness of the only tuberculosis vaccine approved for humans provided superior protection against the deadly disease in a pre-clinical test, report scientists at The University of Texas Health Science Center at Houston in Nature Medicine's Advance Online Publication March 1. Their findings resulted from more than 6 years of research funded by the National Institutes of Health (NIH).

Bacille Calmette-Gurin (BCG) provides only partial protection against tuberculosis (TB) in children and is ineffective in adults. As a result, tuberculosis still kills almost 2 million people a year world wide. "An improved vaccine is widely seen as the best potential method of controlling the disease and is an urgent public health priority," said Chinnaswamy Jagannath, Ph.D., lead author and associate professor at The University of Texas Medical School at Houston.

BCG is a live but weakened form of a bacterium, M. bovis, which causes tuberculosis in cattle. It is sufficiently related to the human pathogen to stimulate production of specialized immune cells that fight off TB infection when it is injected into a person as a vaccine.

Many attempts have been made to improve the vaccine by incorporating antigens (molecular components of the bacteria) to induce a stronger immune response. However, tuberculosis and BCG have evasive mechanisms that prevent the development of stronger immune responses. Investigators at the UT Health Science Center at Houston investigated mechanisms by which BCG evades immune stimulating mechanisms and devised two means to neutralize them. The scientists used genetically-modified organisms and a drug used for organ transplantation to block BCG's evasive mechanisms, causing it to induce stronger immune responses. Research collaborator on the genetically-modified organisms project was Subramanian Dhandayuthapani, Ph.D., an assistant professor at The University of Texas Health Science Center at San Antonio's Medical Research Division in Edinburg, Texas.

This dual approach to the BCG vaccine was associated with a tenfold increase in the number of TB organisms killed and a threefold increase in the duration of protection in tests with an NIH-approved mouse model, Jagannath said.

"The breakthrough is that Dr. Jagannath has countered the ability of TB organisms to subvert immunization," said Robert L. Hunter Jr., M.D., Ph.D., one of the study's two senior authors and chair of the Department of Pathology and Laboratory Medicine at the UT Medical School at Houston.

Tuberculosis hides in cells so the antigens are not recognized by the immune system. The BCG vaccine also does the same thing, as previously reported in The Journal of Immunology in 2006 by Jagannath and Christopher Singh, a doctoral student at The University of Texas Graduate School of Biomedical Sciences at Houston.

"Dr. Jagannath hypothesized that a drug, rapamycin, which modulates the movement of particles in cells, would cause BCG antigens to enter pathways leading to improved immunization," Hunter said. "In addition, Dr. Jagannath had previously demonstrated that genetic deletion of the fpbA gene has similar effects."

Rapamycin is a drug used to fight cancer and inflammation. In 1992, the Organ Transplantation Center at the UT Medical School was first to conduct rapamycin clinical trials. The UT group led by Barry D. Kahan, M.D., Ph.D., now professor emeritus, showed that rapamycin significantly reduces the frequency of acute kidney transplant rejection.

"Our findings break new ground in vaccine research in general and make improvements for antituberculosis vaccines in particular, because they provide a simple and powerful strategy to enhance vaccine efficiency," the researchers wrote in the paper. They now plan to add additional antigens to the BCG vaccine to further improve its effectiveness before clinical trials.


'/>"/>

Contact: Robert Cahill
Robert.Cahill@uth.tmc.edu
713-500-3030
University of Texas Health Science Center at Houston
Source:Eurekalert

Related medicine news :

1. Prosthetic Center of Excellence to Provide Breakthrough Technology to Rehabilitation Patients
2. Neurologist to Announce Breakthrough Headache Treatment
3. Nutrition 21 Launches Breakthrough Weight Management Product: Iceland Health(R) Appetite Control Formula
4. Breakthrough Rx for Relationships Offers Hope
5. Oklahoma State University researchers make breakthrough against poxviruses
6. DHA Hailed as Breakthrough Treatment for Lowering Risk of Developmental Disorders in Premature Infants; Animi-3(R) Prescribed to Women Who Are Not Eating Fish
7. Canine Cancer #1 Fear of Dog Lovers, Web Exclusive by Morris Animal Foundation Provides News on Latest Breakthroughs - Crucial Facts for Dog Owners
8. American Asthma Foundation Announces Breakthrough Discovery
9. A breakthrough in diagnosis of enteric lesions
10. 5,000 Medical Leaders Report Latest Advancements in Biomedical Technologies; Breakthroughs by 2015 Predicted for Alzheimer's, Heart Disease, Cancer, and Diabetes
11. DR. MIRACLES Wins 2008 WWD Beauty Biz Award: Breakthrough Product of the Year!!!
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2017)... ... June 23, 2017 , ... Military Connection friend ... entry to the JFK Virgin Atlantic lounge. , Bensko is no stranger to ... years ago, Bensko dedicated her life to supporting our wounded veterans. A world-class photographer, ...
(Date:6/23/2017)... , ... June 23, 2017 , ... ... Cancer Conference from Sept. 18 to 20. , The two-day conference is focused ... with the goal of improving patients’ lives and eliminating racial breast cancer-related disparities. ...
(Date:6/23/2017)... , ... June 23, 2017 , ... American Farmer, will ... series, which is slated to air fourth quarter 2017. American Farmer airs Tuesdays at ... Hansen, a Danish pharmacist, founded Chr. Hansen in Denmark in 1874 after a groundbreaking ...
(Date:6/23/2017)... ... 2017 , ... Radabaugh & Associates, a locally owned firm ... in North Central West Virginia, is embarking on a cooperative charity drive with ... the region. , The Stepping Stones organization offers a series of personal development ...
(Date:6/22/2017)... ... , ... Groove Ring is excited to announce they've partnered with Olympic runner ... and all-purpose rings. Whether you’re an athlete, adventurer, professional, or love to venture the ... From the rock face to the auto shop, Groove Ring is the world's first ...
Breaking Medicine News(10 mins):
(Date:6/20/2017)... -- Hill-Rom Holdings, Inc. (NYSE: HRC), will host its fiscal third ... 28, 2017, beginning at 7:30 a.m. (CDT) / 8:30 a.m. ... participate in the conference call, dial (877) 304-8969 (domestic) or ... 10 minutes prior to the start to allow time to ... Webcast: A simultaneous webcast of the call ...
(Date:6/14/2017)... -- ivWatch LLC, a medical device company focused on improving ... pleased to announce it was the Bronze Winner last ... Equipment at the 2017 Medical Design Excellence Awards (MDEAs), ... award was presented by Medical Device and Diagnostics Industry ... New York during MD&M East, the ...
(Date:6/12/2017)... 2017 Kineta, Inc., a biotechnology company focused on ... Vice President of R&D and Head of Virology Kristin Bedard ... for the Northwest and Beyond meeting sponsored by Life ... 2017 from 8:30-10:30 AM PDT at the Agora Conference Center ... Dr. Bedard will be joined by other leaders in infectious ...
Breaking Medicine Technology: