Navigation Links
TB breakthrough could lead to stronger vaccine
Date:3/3/2009

A breakthrough strategy to improve the effectiveness of the only tuberculosis vaccine approved for humans provided superior protection against the deadly disease in a pre-clinical test, report scientists at The University of Texas Health Science Center at Houston in Nature Medicine's Advance Online Publication March 1. Their findings resulted from more than 6 years of research funded by the National Institutes of Health (NIH).

Bacille Calmette-Gurin (BCG) provides only partial protection against tuberculosis (TB) in children and is ineffective in adults. As a result, tuberculosis still kills almost 2 million people a year world wide. "An improved vaccine is widely seen as the best potential method of controlling the disease and is an urgent public health priority," said Chinnaswamy Jagannath, Ph.D., lead author and associate professor at The University of Texas Medical School at Houston.

BCG is a live but weakened form of a bacterium, M. bovis, which causes tuberculosis in cattle. It is sufficiently related to the human pathogen to stimulate production of specialized immune cells that fight off TB infection when it is injected into a person as a vaccine.

Many attempts have been made to improve the vaccine by incorporating antigens (molecular components of the bacteria) to induce a stronger immune response. However, tuberculosis and BCG have evasive mechanisms that prevent the development of stronger immune responses. Investigators at the UT Health Science Center at Houston investigated mechanisms by which BCG evades immune stimulating mechanisms and devised two means to neutralize them. The scientists used genetically-modified organisms and a drug used for organ transplantation to block BCG's evasive mechanisms, causing it to induce stronger immune responses. Research collaborator on the genetically-modified organisms project was Subramanian Dhandayuthapani, Ph.D., an assistant professor at The University of Texas Health Science Center at San Antonio's Medical Research Division in Edinburg, Texas.

This dual approach to the BCG vaccine was associated with a tenfold increase in the number of TB organisms killed and a threefold increase in the duration of protection in tests with an NIH-approved mouse model, Jagannath said.

"The breakthrough is that Dr. Jagannath has countered the ability of TB organisms to subvert immunization," said Robert L. Hunter Jr., M.D., Ph.D., one of the study's two senior authors and chair of the Department of Pathology and Laboratory Medicine at the UT Medical School at Houston.

Tuberculosis hides in cells so the antigens are not recognized by the immune system. The BCG vaccine also does the same thing, as previously reported in The Journal of Immunology in 2006 by Jagannath and Christopher Singh, a doctoral student at The University of Texas Graduate School of Biomedical Sciences at Houston.

"Dr. Jagannath hypothesized that a drug, rapamycin, which modulates the movement of particles in cells, would cause BCG antigens to enter pathways leading to improved immunization," Hunter said. "In addition, Dr. Jagannath had previously demonstrated that genetic deletion of the fpbA gene has similar effects."

Rapamycin is a drug used to fight cancer and inflammation. In 1992, the Organ Transplantation Center at the UT Medical School was first to conduct rapamycin clinical trials. The UT group led by Barry D. Kahan, M.D., Ph.D., now professor emeritus, showed that rapamycin significantly reduces the frequency of acute kidney transplant rejection.

"Our findings break new ground in vaccine research in general and make improvements for antituberculosis vaccines in particular, because they provide a simple and powerful strategy to enhance vaccine efficiency," the researchers wrote in the paper. They now plan to add additional antigens to the BCG vaccine to further improve its effectiveness before clinical trials.


'/>"/>

Contact: Robert Cahill
Robert.Cahill@uth.tmc.edu
713-500-3030
University of Texas Health Science Center at Houston
Source:Eurekalert

Related medicine news :

1. Prosthetic Center of Excellence to Provide Breakthrough Technology to Rehabilitation Patients
2. Neurologist to Announce Breakthrough Headache Treatment
3. Nutrition 21 Launches Breakthrough Weight Management Product: Iceland Health(R) Appetite Control Formula
4. Breakthrough Rx for Relationships Offers Hope
5. Oklahoma State University researchers make breakthrough against poxviruses
6. DHA Hailed as Breakthrough Treatment for Lowering Risk of Developmental Disorders in Premature Infants; Animi-3(R) Prescribed to Women Who Are Not Eating Fish
7. Canine Cancer #1 Fear of Dog Lovers, Web Exclusive by Morris Animal Foundation Provides News on Latest Breakthroughs - Crucial Facts for Dog Owners
8. American Asthma Foundation Announces Breakthrough Discovery
9. A breakthrough in diagnosis of enteric lesions
10. 5,000 Medical Leaders Report Latest Advancements in Biomedical Technologies; Breakthroughs by 2015 Predicted for Alzheimer's, Heart Disease, Cancer, and Diabetes
11. DR. MIRACLES Wins 2008 WWD Beauty Biz Award: Breakthrough Product of the Year!!!
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2017)... ... March 24, 2017 , ... ... spark a conversation on the current obstacles facing infection prevention and offer strategies ... deaths caused by these infections. , The print component of “Fighting Infection” ...
(Date:3/24/2017)... Dallas, Texas (PRWEB) , ... March 24, 2017 , ... ... Budget Office score is invalid because it does not obey the rules Congress has ... million full-time equivalent jobs, which the GOP reform would restore. Yet, it estimates a ...
(Date:3/24/2017)... Sedona, Arizona (PRWEB) , ... March 24, 2017 ... ... Shamangelic Healing Center, Sedona, Arizona’s Premier Center for Shamanic Healing and Spiritual Awakening, ... Jorge Luis Delgado, June 9--24, 2017. This sacred and spiritual journey during ...
(Date:3/24/2017)... ... March 24, 2017 , ... ... at the Advanced ERISA Benefit Claims Litigation seminar in Chicago, Illinois. She ... Record, The majority of cases litigated under ERISA involve claims for long-term disability ...
(Date:3/24/2017)... ... March 24, 2017 , ... Empower Brokerage, located in Southlake, ... leads programs. , In February, 2017, Empower Brokerage introduced their new “Performance Partners” ... designed to teach how to maximize their sales efforts, as well as how ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)... PUNE, India , March 24, 2017 ... conjugates market has been growing rapidly as the global sales of ... Globally, the growth in the antibody drug conjugates market is driven ... incidences of cancer and wider therapeutic window offered by ADCs. ... Browse 3 Tables and ...
(Date:3/24/2017)... 2017  GenomeDx Biosciences today announced that six abstracts ... Prostate Cancer Classifier tests will be presented at the ... Congress held March 24 to 28, 2017 in ... is Europe,s largest urological event ... urological field. The abstract titled "Muscle invasive ...
(Date:3/24/2017)... Tenn. , March 23, 2017  Provectus ... or the "Company"), a clinical-stage oncology and dermatology ... announced Definitive Financing Commitment Term Sheet (the "Definitive ... a group of the Company,s stockholders, who are ... Group" in a Form 8-K filed with the ...
Breaking Medicine Technology: