Navigation Links
TB breakthrough could lead to stronger vaccine
Date:3/3/2009

A breakthrough strategy to improve the effectiveness of the only tuberculosis vaccine approved for humans provided superior protection against the deadly disease in a pre-clinical test, report scientists at The University of Texas Health Science Center at Houston in Nature Medicine's Advance Online Publication March 1. Their findings resulted from more than 6 years of research funded by the National Institutes of Health (NIH).

Bacille Calmette-Gurin (BCG) provides only partial protection against tuberculosis (TB) in children and is ineffective in adults. As a result, tuberculosis still kills almost 2 million people a year world wide. "An improved vaccine is widely seen as the best potential method of controlling the disease and is an urgent public health priority," said Chinnaswamy Jagannath, Ph.D., lead author and associate professor at The University of Texas Medical School at Houston.

BCG is a live but weakened form of a bacterium, M. bovis, which causes tuberculosis in cattle. It is sufficiently related to the human pathogen to stimulate production of specialized immune cells that fight off TB infection when it is injected into a person as a vaccine.

Many attempts have been made to improve the vaccine by incorporating antigens (molecular components of the bacteria) to induce a stronger immune response. However, tuberculosis and BCG have evasive mechanisms that prevent the development of stronger immune responses. Investigators at the UT Health Science Center at Houston investigated mechanisms by which BCG evades immune stimulating mechanisms and devised two means to neutralize them. The scientists used genetically-modified organisms and a drug used for organ transplantation to block BCG's evasive mechanisms, causing it to induce stronger immune responses. Research collaborator on the genetically-modified organisms project was Subramanian Dhandayuthapani, Ph.D., an assistant professor at The University of Texas Health Scien
'/>"/>

Contact: Robert Cahill
Robert.Cahill@uth.tmc.edu
713-500-3030
University of Texas Health Science Center at Houston
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Prosthetic Center of Excellence to Provide Breakthrough Technology to Rehabilitation Patients
2. Neurologist to Announce Breakthrough Headache Treatment
3. Nutrition 21 Launches Breakthrough Weight Management Product: Iceland Health(R) Appetite Control Formula
4. Breakthrough Rx for Relationships Offers Hope
5. Oklahoma State University researchers make breakthrough against poxviruses
6. DHA Hailed as Breakthrough Treatment for Lowering Risk of Developmental Disorders in Premature Infants; Animi-3(R) Prescribed to Women Who Are Not Eating Fish
7. Canine Cancer #1 Fear of Dog Lovers, Web Exclusive by Morris Animal Foundation Provides News on Latest Breakthroughs - Crucial Facts for Dog Owners
8. American Asthma Foundation Announces Breakthrough Discovery
9. A breakthrough in diagnosis of enteric lesions
10. 5,000 Medical Leaders Report Latest Advancements in Biomedical Technologies; Breakthroughs by 2015 Predicted for Alzheimer's, Heart Disease, Cancer, and Diabetes
11. DR. MIRACLES Wins 2008 WWD Beauty Biz Award: Breakthrough Product of the Year!!!
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/25/2014)... October 25, 2014 Mesothelioma researchers are ... to receive pemetrexed (Alimta), after his combination drug therapy ... full story , just posted on the Surviving Mesothelioma ... Tokushukai Medical Center in Japan suggests that “maintenance therapy” ... patients who cannot tolerate higher doses of cisplatin. ...
(Date:10/25/2014)... News) -- Researchers who discovered antibiotics in farmed ... for concern. The use of antibiotics in ... consumption contribute to the development of antibiotic-resistant bacteria ... from the study. Each year in the ... people and kill about 23,000, according to the ...
(Date:10/22/2014)... At a time when the national ... athletes at all levels, the UPMC Sports Medicine ... discussion where two powerful messages are lost: Concussions can ... in full recoveries every day. , In striving to ... and research, UPMC and the Concussion Program are unveiling ...
(Date:10/22/2014)... 22, 2014 For Dr. Iris Hunter, a ... it’s an extension of her life’s mission. Her extensive experience ... the owner of FirstLight HomeCare, make it clear that Hunter’s ... me that my work makes a difference in the lives ... spirit, so after much research, I felt ready to start ...
(Date:10/22/2014)... (PRWEB) October 22, 2014 Hay House is ... Beyond Addiction and Upgrade Your Life (Paperback; $10.82) written by ... Yoga & Recovery. This book is meant to help ... a life of recovery. , Recovery 2.0 is not ... Steps; Recovery 2.0 is a guide for what comes next. ...
Breaking Medicine News(10 mins):Health News:New Report Illustrates Extended Mesothelioma Survival with “Maintenance Therapy”, According to Surviving Mesothelioma 2Health News:Researchers Say Antibiotics in Fish a Health Concern 2Health News:University of Pittsburgh Medical Center Launches Initiative to Emphasize Concussions Are Treatable 2Health News:University of Pittsburgh Medical Center Launches Initiative to Emphasize Concussions Are Treatable 3Health News:University of Pittsburgh Medical Center Launches Initiative to Emphasize Concussions Are Treatable 4Health News:Dr. Iris Hunter to Host Grand Opening of FirstLight HomeCare Tomorrow 2Health News:Hay House Announces The Official Release of Recovery 2.0: Move Beyond Addiction and Upgrade Your Life 2Health News:Hay House Announces The Official Release of Recovery 2.0: Move Beyond Addiction and Upgrade Your Life 3
... a medical store, who was missing for the past few days, ... ,Pradeep Goyal's body was handed over to his kin after ... and since then his whereabouts remained obscure, police said adding his ... Monday, police were informed that the body of a man was ...
... a bird flu exercise Tuesday in which all ... to a human,influenza pandemic. ,Senior officials from ... a hypothetical scenario in the "APEC Pandemic Response,Exercise ... a series that will prepare the,emergency management sector ...
... said it has entered into an agreement with the ... Foot and Mouth Disease (FMD) vaccine developed by the ... agreement, we will produce and market the vaccine in ... the requirements of the domestic market and if there ...
... No interest in hobbies, no time for buddies, no ... that the culprit behind these symptoms in their children ... and television can lead to an addiction, with very ... stop putting effort into contact with other people, and ...
... been discovered in mouse,testicles. These are a new class of ... human health //. ,RNA interference is one important way ... ,Greg Hansom of Cold Spring Harbor Laboratory in ... the same US city, found,the new class of RNAs by ...
... diagnosed with autism at 2 years appear to have ... ,Autism is a developmental condition characterized by difficulties with ... and repetitive behaviors, according to background information in the ... during the first year of life, but most diagnoses ...
Cached Medicine News:Health News:APEC Launches Bird Flu Exercise 2Health News:Too Much PC Gaming Makes Children Lonely and Sick 2Health News:Too Much PC Gaming Makes Children Lonely and Sick 3Health News:Autism In Children is Mostly Diagnosed Only at Older Age 2
(Date:10/25/2014)... -- Research and Markets ( http://www.researchandmarkets.com/research/bfqljk/global_and ... "Global and Chinese Hemodialysis Concentrates Industry Report 2014" ... (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , Global and Chinese ... and in-depth study on the current state of ... the Chinese situation. The report provides ...
(Date:10/25/2014)... , Oct. 24, 2014 In conjunction ... quarter 2014 financial results press release, you are invited ... broadcast live over the internet on Monday, November 3, ... Time). A live audio webcast of the ... http://www.durect.com and clicking "Investor Relations."  If you ...
(Date:10/25/2014)... , Oct. 24, 2014  As the ... provide a company access to diverse skill sets ... and round-the clock business hours for efficiency. However, ... hurdles. According to recent research, ... such as seeing a project not move forward ...
Breaking Medicine Technology:Global and Chinese Hemodialysis Concentrates Industry Report 2014 2Global and Chinese Hemodialysis Concentrates Industry Report 2014 3DURECT Corporation Invites You to Join its Third Quarter 2014 Earnings Conference Call 2Work Around the Clock: Successfully Building & Managing Global Virtual Teams 2
... Style Low Binding, Graduated Pipet Tips - ... Eppendorf Style Pipettors.Reduces DNA and protein binding. ... completely by automation. RNAse & DNAse free. ... tips/rack and 10 racks/cs. AVR100 is the ...
... Like all Gilson disposable ... in a sterilized version. Each ... in medical device-quality plastic to ... Sterilization is guaranteed by the ...
10 L, Racked, Pre-sterilized, 96 tips/rack Recommended for 5 & 10 L pipettes. Ideal for pipetting into long, narrow tubes or deep well plates....
... are ideal for PCR ... or for any work ... occur. They are designed ... infectious materials, labelled samples, ...
Medicine Products: