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TB Vaccine Promising as New Way to Fight Type 1 Diabetes
Date:8/9/2012

an endocrinologist at Lenox Hill Hospital in New York City. "But what happens after 20 weeks? How often would they need to give this vaccine?"

"I'm concerned about increasing the levels of TNF in the body," he added. "They're saying that only the insulin-secreting cells are affected, but what are the long-term effects if it's given repeatedly? What about the growing cells in children, because if it works it would be used in children."

Still, he said, "this is important research that helps us understand the pathophysiology of type 1 diabetes."

Faustman said that BCG has an excellent safety record, and has been given to billions of adults and children worldwide to prevent tuberculosis.

Faustman and her colleagues are currently developing phase II trials to test using higher levels of the vaccine.

More information

Learn more about type 1 diabetes from the National Library of Medicine.

SOURCES: Denise Faustman, M.D., Ph.D., director, immunobiology laboratory, Massachusetts General Hospital, Boston; Spyros Mezitis, M.D., endocrinologist, Lenox Hill Hospital, New York City; Aug. 8, 2012 PLOS One, online


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