Navigation Links
TB Drug Treatment Can Lead to Severe Pneumonia
Date:3/24/2008

South African study cites the use of fluoroquinones

MONDAY, March 24 (HealthDay News) -- The use of fluoroquinones to treat children with multidrug-resistant tuberculosis can lead to the development of drug-resistant invasive pneumococcal disease, including severe pneumonia and meningitis.

That finding emerged from a study by researchers at the National Institute for Communicable Diseases in South Africa.

They analyzed 21,521 cases of children with invasive pneumococcal disease and screened 19,404 isolates (90 percent of all cases) for resistance to ofloxacin (a fluoroquinone). Minimum inhibitory concentrations (MIC) for all isolates were measured, and levofloxacin resistance was defined as an MIC of 4mg/L or more. The researchers assessed nose and throat pneumococcal carriage in 65 children in two TB hospitals where invasive pneumococcal disease caused by levofloxacin-resistant Streptococcus pneumoniae had been detected.

Twelve cases of invasive pneumococcal disease were identified as levofloxacin-resistant, all in children younger than 15 years old. There were five deaths among the 11 patients whose outcomes were known.

The researchers found that invasive pneumococcal disease caused by levofloxacin-resistant S. pneumoniae was associated with a history of TB treatment. Eight out of nine (89 percent) children with non-susceptible isolates had a history of TB treatment, compared to 396 of 2,202 (18 percent) of children with susceptible isolates. Among the hospitalized children with nose and throat pneumococcal carriage, nearly 100 percent of the bacteria were levofloxacin resistant.

"Our data suggest that the use of fluoroquinones to treat multidrug-resistant tuberculosis in children has led to the emergence of invasive pneumococcal diseases caused by levofloxacin-non-susceptible S. pneumoniae and its nosocomial spread among children," the researchers concluded.

The study was published by The Lancet and released Monday to coincide with World TB Day.

More information

The U.S. National Foundation for Infectious Diseases has more about pneumococcal disease.



-- Robert Preidt



SOURCE: The Lancet, news release, March 24, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Youth sports concussion program points to need for proper treatment of concussion in children
2. Prostate size and other neglected factors influence prostate cancer treatment satisfaction
3. Quality of Life an Issue in Prostate Cancer Treatment
4. Molecular biology of sleep apnea could lead to new treatments
5. One-Third of U.S. Primary Care Physicians and Cardiologists Do Not Currently Prescribe Treatment to Meet HDL Cholesterol Targets as Recommended By National Guidelines
6. Varian Announces Global Clinical Council to Develop RapidArc(TM) Cancer Treatments
7. Arizona Senate Approves Smoking Cessation Treatments for State Medicaid Beneficiaries
8. New Foam Treatment for Varicose Veins
9. New Interventional Radiology Treatment Shows Hope for People With Complications from Bone Marrow, Stem Cell Transplants
10. Few Women Hear About Uterine Fibroid Embolization Treatment Option Directly From Gynecologists
11. Researchers study new drug and indications for heated chemotherapy treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... As a ... Magna Cum Laude and his M.D from the David Geffen School of Medicine at ... returned to Los Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars ...
(Date:6/24/2016)... Angeles, CA (PRWEB) , ... June 24, 2016 , ... ... surgery procedures that most people are unfamiliar with. The article goes on to state ... procedures, but also many of these less common operations such as calf and cheek ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Pulmonary ... Dallas that it will receive two significant new grants to support its work ... marked its 25th anniversary by recognizing patients, medical professionals and scientists for their ...
(Date:6/24/2016)... ... June 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain ... for a minimum wage raise to $12 an hour by 2020 and then adjusting it ... the lost value of the minimum wage, assure the wage floor does not erode again, ...
(Date:6/24/2016)... ... June 24, 2016 , ... Puradigm® & Innovative Solutions ... initiated cultivation and processing operations at its production facility, and opened its first ... is the manufacturer of a complete system of proactive air and surface purification ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 2016 Roche (SIX: RO, ROG; OTCQX: RHHBY) ... Elecsys BRAHMS PCT (procalcitonin) assay as a dedicated testing ... With this clearance, Roche is the first IVD company ... for sepsis risk assessment and management. PCT ... PCT levels in blood can aid clinicians in assessing ...
(Date:6/23/2016)... , , , WHEN: ... , , , , LOCATION: , , , Online, with ... , EXPERT PANELISTS:  , , , Frost & Sullivan,s Global Vice ... Senior Industry Analyst, Divyaa Ravishankar and Unmesh Lal, Program Manager , ... industry is witnessing an exceptional era. Several new demand spaces, such ...
(Date:6/23/2016)... -- The vast majority of dialysis patients currently receive ... usually 3 times a week, with treatment times averaging ... equipment preparation and wait time.  This regimen can be ... who are elderly and frail.  Many elderly dialysis patients ... for some duration of time. Residents in ...
Breaking Medicine Technology: