Navigation Links
TB Drug Treatment Can Lead to Severe Pneumonia
Date:3/24/2008

South African study cites the use of fluoroquinones

MONDAY, March 24 (HealthDay News) -- The use of fluoroquinones to treat children with multidrug-resistant tuberculosis can lead to the development of drug-resistant invasive pneumococcal disease, including severe pneumonia and meningitis.

That finding emerged from a study by researchers at the National Institute for Communicable Diseases in South Africa.

They analyzed 21,521 cases of children with invasive pneumococcal disease and screened 19,404 isolates (90 percent of all cases) for resistance to ofloxacin (a fluoroquinone). Minimum inhibitory concentrations (MIC) for all isolates were measured, and levofloxacin resistance was defined as an MIC of 4mg/L or more. The researchers assessed nose and throat pneumococcal carriage in 65 children in two TB hospitals where invasive pneumococcal disease caused by levofloxacin-resistant Streptococcus pneumoniae had been detected.

Twelve cases of invasive pneumococcal disease were identified as levofloxacin-resistant, all in children younger than 15 years old. There were five deaths among the 11 patients whose outcomes were known.

The researchers found that invasive pneumococcal disease caused by levofloxacin-resistant S. pneumoniae was associated with a history of TB treatment. Eight out of nine (89 percent) children with non-susceptible isolates had a history of TB treatment, compared to 396 of 2,202 (18 percent) of children with susceptible isolates. Among the hospitalized children with nose and throat pneumococcal carriage, nearly 100 percent of the bacteria were levofloxacin resistant.

"Our data suggest that the use of fluoroquinones to treat multidrug-resistant tuberculosis in children has led to the emergence of invasive pneumococcal diseases caused by levofloxacin-non-susceptible S. pneumoniae and its nosocomial spread among children," the researchers concluded.

The study was published by The Lancet and released Monday to coincide with World TB Day.

More information

The U.S. National Foundation for Infectious Diseases has more about pneumococcal disease.



-- Robert Preidt



SOURCE: The Lancet, news release, March 24, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Youth sports concussion program points to need for proper treatment of concussion in children
2. Prostate size and other neglected factors influence prostate cancer treatment satisfaction
3. Quality of Life an Issue in Prostate Cancer Treatment
4. Molecular biology of sleep apnea could lead to new treatments
5. One-Third of U.S. Primary Care Physicians and Cardiologists Do Not Currently Prescribe Treatment to Meet HDL Cholesterol Targets as Recommended By National Guidelines
6. Varian Announces Global Clinical Council to Develop RapidArc(TM) Cancer Treatments
7. Arizona Senate Approves Smoking Cessation Treatments for State Medicaid Beneficiaries
8. New Foam Treatment for Varicose Veins
9. New Interventional Radiology Treatment Shows Hope for People With Complications from Bone Marrow, Stem Cell Transplants
10. Few Women Hear About Uterine Fibroid Embolization Treatment Option Directly From Gynecologists
11. Researchers study new drug and indications for heated chemotherapy treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... , ... Brent Kasmer, a legally blind and certified personal trainer is helping to develop a ... fitness app plans to fix the two major problems leading the fitness industry today:, ... type program , They don’t eliminate all the reasons people quit their exercise ...
(Date:6/25/2016)... ... June 25, 2016 , ... "With 30 hand-drawn hand gesture animations, FCPX users ... - CEO of Pixel Film Studios. , ProHand Cartoon’s package transforms over 1,300 ... Pro X . Simply select a ProHand generator and drag it above media or ...
(Date:6/25/2016)... Montreal, Canada (PRWEB) , ... June 25, 2016 , ... ... the pursuit of success. In terms of the latter, setting the bar too high ... low, risk more than just slow progress toward their goal. , Research from ...
(Date:6/24/2016)... ... June 24, 2016 , ... The ... in Dallas that it will receive two significant new grants to support its ... PHA marked its 25th anniversary by recognizing patients, medical professionals and scientists for ...
(Date:6/24/2016)... ... ... People across the U.S. are sharpening their pencils and honing their writing ... which patients and their families pay tribute to a genetic counselor by nominating him ... Genetic Counselors (NSGC) Annual Education Conference (AEC) this September. , In April, Genome ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)...  In a startling report released today, National Safety Council ... a comprehensive, proven plan to eliminate prescription opioid overdoses. ... states are tackling the worst drug crisis in recorded U.S. history, ... Kentucky , New Mexico , ... the 28 failing states, three – Michigan , ...
(Date:6/23/2016)... 2016 Bracket , a leading clinical trial ... clinical outcomes platform, Bracket eCOA (SM) 6.0, at the ... – 30, 2016 in Philadelphia , Pennsylvania.  ... Assessment product of its kind to fully integrate with RTSM, ... eCOA 6.0 is a flexible platform for electronic clinical outcomes ...
(Date:6/23/2016)...  Guerbet announced today that it has been named ... . One of 12 suppliers to receive ... support of Premier members through exceptional local customer service ... to lower costs. ... outstanding customer service from Premier," says Massimo Carrara ...
Breaking Medicine Technology: