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T vs. B: Re-engineered human T cells effectively target and kill cancerous B cells
Date:9/18/2007

acy of these T cells in eradicating cancerous B cells, said Dr. Brentjens. This concept of T cell persistence being critical to treatment efficacy is one we are further investigating in current and upcoming clinical trials.

The results have given the researchers further evidence that the technique will work in humans. When transplanted back into a patient, these engineered T cells could then attack and kill tumor cells bearing the CD19 protein. CD19 is not found on the surface of bone marrow stem cells, so these modified T cells are reasonably safe since they should not attack other blood forming cells in the bone marrow following treatment, Dr. Brentjens said.

Based on the results of their findings, the MSKCC researchers are currently conducting a clinical trial using this method in patients with chemotherapy-resistant CLL. CLL is currently considered an incurable cancer, Dr.

Brentjens said, although the disease generally progresses slowly.


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Contact: Greg Lester
lester@aacr.org
267-646-0554
American Association for Cancer Research
Source:Eurekalert

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