Navigation Links
T-cell therapy eradicates an aggressive leukemia in 2 children
Date:3/25/2013

T cells to selectively kill another type of immune cell called B cells, which had become cancerous.

T cells are the workhorses of the immune system, recognizing and attacking invading disease cells. However, cancer cells fly under the radar of immune surveillance, evading detection by T cells. The new approach custom-designs T cells to "see" and attack the cancer cells.

The researchers removed some of each patient's own T cells and modified them in the laboratory to create a type of CAR (chimeric antigen receptor) cell called a CTL019 cell. These cells are designed to attack a protein called CD19 that occurs only on the surface of certain B cells.

By creating an antibody that recognizes CD19 and then connecting that antibody to T cells, the researchers created in CTL019 cells a sort of guided missile that locks in on and kills B cells, thereby attacking B-cell leukemia. After being returned to the patient's body, the CTL019 cells multiply a thousand times over and circulate throughout the body. Importantly, they persist for months afterward, guarding against a recurrence of this specific type of leukemia.

While the CTL019 cells eliminate leukemia, they also can generate an overactive immune response, called a cytokine release syndrome, involving dangerously high fever, low blood pressure, and other side effects. This complication was especially severe in Emily, and her hospital team needed to provide her with treatments that rapidly relieved the treatment-related symptoms by blunting the immune overresponse, while still preserving the modified T cells' anti-leukemia activity.

"The comprehensive testing plan that we have put in place to study patients' blood and bone marrow while they're undergoing this therapy is allowing us to be able to follow how the T cells are behaving in patients in real time, and guides us to be able to design more detailed and specific experiments to answer critical questions that come up from o
'/>"/>

Contact: Rachel Salis-Silverman
Salis@email.chop.edu
267-426-6063
Children's Hospital of Philadelphia

Holly Auer
holly.auer@uphs.upenn.edu
215-200-2313
Perelman School of Medicine, University of Pennsylvania


Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Infusion of stem cells and specially generated T-cells from same donor improves leukemia survival
2. Denosumab reduces burden of giant-cell tumor of the bone
3. Mayo Clinic completes first genome-wide analysis of peripheral T-cell lymphomas
4. UCLA, Caltech research on immune-cell therapy could strengthen promising melanoma treatment
5. Physical therapy as effective as surgery for torn meniscus and arthritis of the knee
6. PREFERRED Therapy Providers Selects WebOutcomes to Deliver Web-Based Outcomes for Their National Provider Network
7. Gene Therapy for Human Disease: Clinical Advances and Challenges
8. Immune Therapy Shows Early Promise for Advanced Leukemia
9. Dennis R. Hill MD Announces Launch of High Dose Rate Brachytherapy of Prostate Cancer Website
10. Therapy as Good as Surgery for Some With Torn Knee Cartilage
11. Women's Excellence in Pelvic Floor Physical Therapy Near Pontiac, MI, Now Offers Therapy After Vaginal Delivery to Prevent Urinary Incontinence, Improve Sexual Function
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... measure damaging "brain tsunamis" in injured patients without ... to reality, thanks to pioneering research at the ... research team, led by Jed Hartings, PhD, research ... the UC College of Medicine, has shown that ... brain like tsunami wavescan be measured by the ...
(Date:9/30/2014)... apnea is a potential health risk for millions of Americans, ... the disorder: a "fat" tongue. "This is the first ... tongue of obese patients with obstructive sleep apnea," study senior ... the University of Pennsylvania Medical Center, said in a news ... Oct. 1. Sleep apnea is a common disorder in ...
(Date:9/30/2014)... PROVIDENCE, R.I. [Brown University] Autism is no stranger ... the East African nation is access to clinical services, ... autism diagnostic measure, for example, validated for use in ... small new study, however, researchers at Brown University and ... diagnostic approach that they implemented at two sites in ...
(Date:9/30/2014)... WASHINGTON Legislation passed in 2003 to slow the ... government to treat Medicare patients has had no meaningful ... of researchers in the Journal of Clinical Oncology ... of outpatient chemotherapy to treat colorectal and lung cancers, ... oncologists prescribe those drugs following the implementation of the ...
(Date:9/30/2014)... New York, NY (PRWEB) September 30, 2014 ... and falling demand have hampered growth in the ... Popular diets have caused consumers to moderate their ... growing consumer preferences for premium varieties shrunk the ... bread products. Successful operators proactively responded by introducing ...
Breaking Medicine News(10 mins):Health News:Researchers show EEG's potential to reveal depolarizations following TBI 2Health News:Researchers show EEG's potential to reveal depolarizations following TBI 3Health News:Could a 'Fat Tongue' Be a Factor in Sleep Apnea? 2Health News:New diagnostic approach for autism in Tanzania 2Health News:New diagnostic approach for autism in Tanzania 3Health News:New diagnostic approach for autism in Tanzania 4Health News:Landmark Medicare law had little impact on reducing chemotherapy cost 2Health News:Bread Production in the US Industry Market Research Report from IBISWorld Has Been Updated 2Health News:Bread Production in the US Industry Market Research Report from IBISWorld Has Been Updated 3
... space technology is helping doctors diagnose and monitor ... its early stages, before it causes heart attacks ... the country are using ArterioVision software initially developed ... along with a standardized, painless, non-invasive ultrasound examination ...
... J. Fox Foundation for Parkinson's Research announced $710,000 in ... leveraging existing data and patient populations to initially characterize ... that may differ in onset, progression and response to ... of Parkinson's disease -- for patients, researchers and clinicians ...
... of concern as most of them are related to mental ... problems due to which people abstained from work. ... Development (CIPD) on about 30,000 workers revealed that mental illness ... muscle related problems like bad back. ,The study ...
... N.J., Centocor, Inc. and Schering-Plough Corporation (NYSE: SGP) ... approved a new indication for REMICADE(R) (infliximab) allowing ... (CD) in pediatric patients aged 6 to 17 ... including a corticosteroid, an immunomodulator and primary nutrition ...
... Annual Meeting of the Society for Vascular Surgery, ... worldwide launch of the Cordis AVIATOR (TM) Plus ... for patients with carotid and or renal artery ... and low profile .014 inch rapid exchange (RX) ...
... Ozzy Osbourne says that getting rid of smoking was more ... and alcohol . ,The former hellraiser, who quit ... he has not gotten hooked to smoking again.,He revealed that ... himself with nicotine patches. ,"They're all a b**ger ...
Cached Medicine News:Health News:NASA Technology Helps Detect and Treat Heart Disease and Strokes 2Health News:NASA Technology Helps Detect and Treat Heart Disease and Strokes 3Health News:Michael J. Fox Foundation Awards $710,000 to Understanding of Parkinson's Disease Subtypes 2Health News:Mental Illness Foremost Reason for Absenteeism 2Health News:Remicade(R) Get Approval for First and Only Biologic Treatment for Pediatric Crohn's Disease 2Health News:New Balloon Catheter Available Worldwide for Carotid and Renal Angioplasty 2
(Date:10/1/2014)... , Suisse, October 1, 2014 ... clinique et dans le domaine de l,analyse des ... lancé aujourd,hui une solution de diagnostic in vitro ... une analyse complète de la mucoviscidose dans un ... et de caractériser tous les types de variantes ...
(Date:10/1/2014)... , October 1, 2014 ... Next Generation Sequencing (NGS) data analysis, today launches a ... cystic fibrosis analysis in a single NGS experiment. The ... all types of variants in a single NGS experiment ... it has not been possible to simultaneously analyse all ...
(Date:9/30/2014)... the health and safety of Canadians is our government,s highest priority.  ... tools at its disposal to help ensure that the drugs Canadians ... that end, Health Canada has taken ... of all drug products from three plants in ... Apotex Pharmachem India Pvt Ltd , Apotex Research Private Limited ...
Breaking Medicine Technology:Sophia Genetics lance une analyse complète du gène CFTR dans un essai clinique SGN 2Sophia Genetics lance une analyse complète du gène CFTR dans un essai clinique SGN 3Sophia Genetics Launches Full CFTR Analysis in Single Clinical Grade NGS Experiment 2Statement by the Honourable Rona Ambrose on the import ban of drug products from three plants in India 2
... Calif., Dec. 6, 2011 A new study ... clinics across the United States witnessed opiate prescriptions for ... 2008.  Dr. Michael Lowenstein, co-medical director for the Waismann ... , warns that this increase signals the gaining popularity ...
... a pioneer in the innovative treatment of extracorporeal ... that the first patient has been enrolled in ... of the company,s photopheresis technology in the treatment ... An estimated 15,000 new patients worldwide are diagnosed ...
Cached Medicine Technology:Rise in Opioid Use for Abdominal Pain Points to Larger Problem Warns Waismann Method Medical Director 2Rise in Opioid Use for Abdominal Pain Points to Larger Problem Warns Waismann Method Medical Director 3First Patient Enrolled in Therakos Phase Two Study for Treatment of Graft-versus-Host Disease 2First Patient Enrolled in Therakos Phase Two Study for Treatment of Graft-versus-Host Disease 3
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: