Navigation Links
T cell repertoire changes predictive of anti-CTLA-4 cancer immunotherapy outcome revealed
Date:5/28/2014

Sequenta, Inc. today announced publication of a study done in collaboration with researchers from UCSF and UCLA that used the company's proprietary LymphoSIGHT immune repertoire sequencing platform to investigate the effects of anti-CTLA-4 antibody on the number and types of T cells present in a patient's blood. The results, which appear in the May 28 issue of Science Translational Medicine, shed light on the mechanism of action of this type of cancer immunotherapy and suggest that immune repertoire sequencing could be used to predict which patients will have improved survival in response to treatment.

"Immune repertoire sequencing is a new tool that allows us to assess the totality and complexity of immune responses in ways not previously possible," said Lawrence Fong, M.D., Professor, Division of Hematology/Oncology, Department of Medicine, UCSF. "Our analysis of anti-CTLA-4 antibody treated patients using the LymphoSIGHT platform revealed that this therapy induces profound turnover and large-scale remodeling of the entire human T cell repertoire. These findings have implications for understanding how cancer immunotherapy works, which patients will benefit, and the etiology of side effects, such as autoimmune responses."

The researchers used next-generation sequencing to assess the impact of CTLA-4 blockade on changes to the T cell repertoire in 25 metastatic castration-resistant prostate cancer patients treated with ipilimumab and GM-CSF, 21 metastatic melanoma patients treated with tremelimumab, and nine untreated control subjects. Results showed that patients with longer survival had significantly lower numbers of T cell clones (sets of T cells that all express the same receptor) that decreased in frequency after treatment compared to patients with shorter survival. This association held for both the prostate cancer patients (p < 0.01) and the melanoma patients (p < 0.05).

"By leveraging the power of Sequenta's LymphoSIGHT platform for immune repertoire profiling, we and our collaborators have uncovered new aspects of the mechanism of action of anti-CTLA-4 monoclonal antibodies in human cancers," said Tom Willis, CEO of Sequenta. "We have also demonstrated the potential of next-generation sequencing analysis of the immune repertoire for identification of patterns that may predict clinical benefit of immunotherapies, which will be crucial for optimal use of currently available treatments and efficient development of new ones."


'/>"/>

Contact: Erin Davis
erin.davis@sequenta.com
415-640-9624
Sequenta Inc.
Source:Eurekalert

Related medicine news :

1. Yale Cancer Center studies find lifestyle changes improve biomarkers for breast cancer recurrence and mortality
2. Researchers ID changes that may occur in neural circuits due to cocaine addiction
3. TB lung infection causes changes in the diversity of gut bacteria in mice
4. Mount Sinai researchers identify changes that may occur in neural circuits due to addiction
5. Second opinion changes diagnosis from incurable to curable cancer
6. The Pael-R gene does not mediate the changes in rotenone-induced PD model cells
7. Changes in processing, handling could reduce commercial fishing injuries
8. DNA modifications measured in blood signal related changes in the brain
9. Epigenetic changes could explain type 2 diabetes
10. Researchers find changes to protein SirT1
11. NIH scientists map gene changes driving tumors in common pediatric soft-tissue cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/12/2016)... , ... February 12, 2016 , ... ... announced that nominations have closed for the ISE Southeast Awards 2016. Finalists and ... announced at the ISE® Southeast Executive Forum and Awards Gala on March 15, ...
(Date:2/12/2016)... FL (PRWEB) , ... February 12, 2016 , ... ... as a Service (WaaS), today announced the integration of Clarity Intelligence Platform (CIP) ... channel partners to offer real-time business intelligence (BI) to their small and medium ...
(Date:2/12/2016)... ... February 12, 2016 , ... Fisher House Foundation Chairman and ... J. Lee, Nevada Military Support Alliance president Scott Bensing, and Peggy Kearns Director, VA ... Southern Nevada Healthcare System. This will be the first Fisher House in Nevada, ...
(Date:2/12/2016)... ... February 12, 2016 , ... The Jones Agency, a family owned insurance ... is launching a cooperative charity drive with the Tarrant Area Food Bank in the ... individuals and families in need, the Tarrant County Food Bank offers hope and security ...
(Date:2/12/2016)... Columbus, OH (PRWEB) , ... February 12, 2016 , ... ... families of the greater Columbus, OH area. The latest campaign focuses on the fight ... the disease. Donations are now being accepted here . , Carmen is a ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)... , Feb. 12, 2016 Hypermarcas S.A. ... cash tender offer (the "Tender Offer") to purchase ... aggregate principal amount of its 6.500% Senior Notes ... Nos. US44915JAA88/ USP5246AAF05) (the "Notes"). In connection with ... "Consent Solicitation") consents (the "Consents") of the holders ...
(Date:2/12/2016)... 12, 2016   HeartWare International, Inc . (NASDAQ: ... webcast to discuss its financial results for the three ... February 25, 2016 at 8:00 a.m. ET.  The company ... conference call and webcast.  On the conference call and ... from the fourth quarter and business outlook.   ...
(Date:2/12/2016)... On Thursday, Feb. 11, 2016, surgeons at ... North Austin Medical Center successfully completed the first robotic ... Surgical System with Trumpf Medical,s advanced operating table, ... , M.D., colorectal surgeon at the Texas Institute for ... Motion technology, which seamlessly combines the da Vinci Xi ...
Breaking Medicine Technology: