Navigation Links
T cell immunity enhanced by timing of interleukin-7 therapy
Date:2/1/2008

MADISON -- That the cell nurturing growth factor interleukin-7 can help ramp up the ability of the immune system to remember the pathogenic villains it encounters is well known.

But precisely how this natural protein works its magic on the cells of the immune system is not well understood. Now, however, in research that may have implications for developing vaccines against HIV and cancer, a team of scientists from the University of Wisconsin-Madison has found that the timing of interleuin-7 therapy is critical for increasing the number of killer cells that zero in on and destroy virus-infected cells.

Writing in the current online issue (Feb. 1, 2008) of the Journal of Clinical Investigation, a team led by UW-Madison School of Veterinary Medicine Professor of pathobiological sciences Marulasiddappa Suresh reports that therapeutic administration of interleukin-7 can be linked to a stage of early infection to effectively increase the number of a type of killer cell that recognizes and selectively assassinates virus-infected cells.

"These cells need to get interleukin-7 for their survival," explains Suresh, of the killer immune cell known as CD8 T cells, a type of white blood cell that attacks virus-infected cells, foreign cells and cancer cells. Interleukin-7 is produced in very small amounts in bone marrow, spleen, and the thymus, but scientists have been able to isolate and synthesize the agent, which is now in pre-clinical testing for a variety of conditions.

"This is one of the most exciting cytokines in pre-clinical human trials," says Suresh. "The idea is that it might be used as an immune restorative agent. It is absolutely essential for normal development and functioning of the immune system."

Effectively stimulating the immune system -- the complex of organs and cells that defends the body against infection and disease -- is a grail of biomedical science in the fight against infectious diseases.

Suresh explains that upon infe
'/>"/>

Contact: Marulasiddappa Suresh
sureshm@svm.vetmed.wisc.edu
608-265-9791
University of Wisconsin-Madison
Source:Eurekalert

2

GOOD

Page: 1 2 3

Related medicine news :

1. JDRF to establish an autoimmunity center at University of Colorado Denver
2. Chopped up proteins trigger autoimmunity
3. Violent sex acts boost insects immunity system
4. More Energy & Immunity With Vitamin Supplements This Winter
5. CD200 stifles anti-tumor immunity
6. Probiotics Play Critical Role in Pediatric Health and Immunity
7. LifeQuest Announces End of Immunity Health Challenge Contest
8. Brookdale Senior Living Announces Enhanced Web Site
9. NHP Reports Third Quarter 2007 Revenue and FFO Growth and Enhanced Disclosure Information
10. PreViser Launches New Website and Enhanced Version of Its Oral Disease and Risk Assessment Software
11. The American Pain Foundation (APF) and The HealthCentral Network Collaborate to Develop Enhanced Internet Resources for People with Pain
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/18/2013)... HealthDay Reporter , , FRIDAY, May 17 (HealthDay News) ... edition of what is considered the "bible" of modern ... continues. "This is unprecedented, the amount of commentary ... of the American Psychiatric Association (APA). "It,s been an ... You have to evaluate it and then make your ...
(Date:5/18/2013)... (May 18, 2013) The use of a ... colonoscopy, according to new research presented today at ... begins days in advance of the procedure, includes ... to be taken at strict intervals. The better ... to see cancer and precancerous polyps in the ...
(Date:5/18/2013)... 2013 Assisted living and retirement ... safety and comfort of their residents. Systems Technologies ... with an effective and cost-efficient solution – VisionLink ... integrated, turnkey communications solution that helps nurses provide ... independence and privacy. , The VisionLink ...
(Date:5/18/2013)... (PRWEB) May 18, 2013 The Communities ... the special places we call home. These are the townships, ... They are the locations where the people are friendly and ... takes viewers off the highways and shares the best in ... both nations with an American sports and film celebrity. It ...
(Date:5/18/2013)... TheBeautyPlace.com answers important questions about the hairloss ... a result of stress, nutrient deficiency or wearing a ... of men suffer from male patterned baldness. ... hair transplant surgery, but additionally carries a hair care ... Bosley Professional Strength. Their product line is a five-step ...
Breaking Medicine News(10 mins):Health News:Latest Edition of Psychiatry's 'Bible' Launched Amid Controversy 2Health News:Latest Edition of Psychiatry's 'Bible' Launched Amid Controversy 3Health News:Latest Edition of Psychiatry's 'Bible' Launched Amid Controversy 4Health News:New smartphone application improves colonoscopy preparation 2Health News:VisionLink Nurse Call System's New Features Serve the Unique Needs of Retirement Communities 2Health News:VisionLink Nurse Call System's New Features Serve the Unique Needs of Retirement Communities 3Health News:Communities of Distinction TV Presents "A Place to Call Home" Segment 2Health News:TheBeautyPlace.com Features the Two New Best-Selling Hairloss Products: Bosley Professional Strength and Nioxin Systems 2Health News:TheBeautyPlace.com Features the Two New Best-Selling Hairloss Products: Bosley Professional Strength and Nioxin Systems 3
... VanTine HealthDay Reporter , FRIDAY, Dec. 3 (HealthDay News) ... interview, attractive women may be at a disadvantage, a new study ... men were twice as likely to generate requests for an interview, ... up to 30 percent less likely to get a response, whether ...
... FRIDAY, Dec. 3 (HealthDay News) -- If the expression "out ... may be at risk of forgetting about the global AIDS ... coverage of HIV/AIDS fell more than 70 percent in developed ... that tracked coverage in 115 leading broadsheet newspapers in 41 ...
... a quarter of Americans live in rural areas, which consistently ... suburban areas. Among the complex causes for this disparity is ... and almost 4 out of 10 rural residents live ... Finding the time, transportation, and financial resources for travel to ...
... News) -- Young women with a menopause-like condition called ... new study suggests. Women with the condition, called ... hormones, develop hot flashes, typically become infertile and, in ... develop as early as the teens or 20s, according ...
... children born with a rare genetic disease, according to ... Advancement of Science. The research was led by ... at Iowa State University, in collaboration with Dr. Patricia ... the Iowa State College of Veterinary Medicine, the University ...
... Goodwin HealthDay Reporter , THURSDAY, Dec. 2 (HealthDay ... circuitry of brain connections may someday be used to diagnose ... Boston and the University of Utah used MRIs to analyze ... in 30 males aged 8 to 26 with high-functioning autism ...
Cached Medicine News:Health News:Good Looks May Help Land the Interview -- for Men 2Health News:Good Looks May Help Land the Interview -- for Men 3Health News:Dramatic Decline Seen in AIDS News Coverage 2Health News:ALBERT EINSTEIN COLLEGE OF MEDICINE HELPS ADDRESS NEED FOR IMPROVED CANCER CARE IN RURAL AMERICA 2Health News:Depression Screening Urged for Young Women With Menopause-Like Symptoms 2Health News:New discovery prevents symptoms of rare genetic disorder 2Health News:Brain Scan Might Someday Spot Autism 2Health News:Brain Scan Might Someday Spot Autism 3
(Date:5/17/2013)... 17, 2013  PENTAX Medical, a healthcare industry ... global leader in ultrasound imaging, recently announced renewed ... enable further innovation in the development of Endoscopic ... systems and PENTAX Medical endoscopic portfolio have formed ... EUS systems. This agreement will continue to grow ...
(Date:5/17/2013)... May 17, 2013 Oramed Pharmaceuticals ... oral drug delivery systems, announced today that the United ... Company,s Investigational New Drug application(IND) for ORMD-0801, its oral ... have the FDA clearance to proceed," stated ... trial is a major milestone for Oramed and we ...
(Date:5/16/2013)... ZURICH , May 17, 2013 ... Technology and Research (A*STAR) and Switzerland,s ... has been dosed in a Phase 1 clinical trial with ... Qbeta virus-like particle (VLP) technology. In this first Phase 1 ... candidate and its potential to protect against H1N1 influenza infection ...
Breaking Medicine Technology:PENTAX Medical And Hitachi-Aloka Medical Continue Joint Innovation And Global Leadership In Endoscopic Ultrasound Systems 2PENTAX Medical And Hitachi-Aloka Medical Continue Joint Innovation And Global Leadership In Endoscopic Ultrasound Systems 3Oramed Receives FDA Clearance to Initiate Oral Insulin Trials in the U.S. 2Oramed Receives FDA Clearance to Initiate Oral Insulin Trials in the U.S. 3A*STAR and Cytos Bring Singapore's First Influenza Vaccine to Clinical Testing 2A*STAR and Cytos Bring Singapore's First Influenza Vaccine to Clinical Testing 3A*STAR and Cytos Bring Singapore's First Influenza Vaccine to Clinical Testing 4A*STAR and Cytos Bring Singapore's First Influenza Vaccine to Clinical Testing 5A*STAR and Cytos Bring Singapore's First Influenza Vaccine to Clinical Testing 6
... Safety and Efficacy of Tengion,s Neo-Bladder Construct ... in Spinal Cord Injury Patients, ... medicine, announced today it has initiated a Phase 2,multi-center clinical trial ... study is being conducted in 10 adult,patients with neurogenic bladder due ...
... risk in ... with osteoporosis, INDIANAPOLIS, Sept. 14 Today, Eli Lilly ... and Drug Administration,(FDA) has approved its osteoporosis drug EVISTA(R) (raloxifene ... breast cancer in two populations:,postmenopausal women with osteoporosis and postmenopausal ...
Cached Medicine Technology:Tengion Launches Second Phase 2 Clinical Trial of Regenerated Human Organ 2Tengion Launches Second Phase 2 Clinical Trial of Regenerated Human Organ 3FDA Approves Lilly's Osteoporosis Drug EVISTA(R) (raloxifene HCl) to Reduce The Risk of Invasive Breast Cancer in Two Populations of Postmenopausal Women 2FDA Approves Lilly's Osteoporosis Drug EVISTA(R) (raloxifene HCl) to Reduce The Risk of Invasive Breast Cancer in Two Populations of Postmenopausal Women 3FDA Approves Lilly's Osteoporosis Drug EVISTA(R) (raloxifene HCl) to Reduce The Risk of Invasive Breast Cancer in Two Populations of Postmenopausal Women 4FDA Approves Lilly's Osteoporosis Drug EVISTA(R) (raloxifene HCl) to Reduce The Risk of Invasive Breast Cancer in Two Populations of Postmenopausal Women 5FDA Approves Lilly's Osteoporosis Drug EVISTA(R) (raloxifene HCl) to Reduce The Risk of Invasive Breast Cancer in Two Populations of Postmenopausal Women 6
Spurling-Kerrison (Colclough) Laminectomie Rongeur. 15 cm - 6, thick footplate, large handle, 40 up-cutting, jaws 3 mm wide....
Kerrison (Micro) Laminectomie Rongeur, with ejector. 18 cm - 7 1/8, with thick footplate, small handle, 90 up-cutting, jaws 2 mm wide....
... Instrument Set offers maximum distraction with minimal ... by the Tangent Posterior Impacted Instrument Set ... to reproduce the technique. Set offers 9 ... body distraction. A variety of sizes of ...
Regulates physiological flow within normal ranges of Intraventricular Pressure (IVP) in the supine, sitting or standing position....
Medicine Products: