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T-Cell Duplication Delayed Up to 3 Days After Infection
Date:4/11/2008

shows a similar and extended delay of approximately 72 hours before they begin to divide, and that this is true in both lymphoid and non-lymphoid tissues. This delay occurred despite the fact that the viral antigen reached T-cell-stimulatory levels within six to 12 hours after infection," Whitton said.

She and her colleagues "were very much surprised by the discovery that memory cells didn't begin proliferation sooner than their naive counterparts. Memory T-cells are central to the protective immunity of infections and vaccinations, because they act against subsequent encounters with specific microorganisms. Compared to naive cells, memory T-cells can be triggered by lower antigen levels, and their initial response to infection, such as the production of cytokines, is more rapid and more effective."

More information

The Nemours Foundation has more about the immune system.



-- Robert Preidt



SOURCE: Scripps Research Institute, news release, April 10, 2008


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