Navigation Links
Systems biology helps to understand hematopoiesis
Date:5/21/2010

Our body reacts to blood loss by stimulating the production of red blood cells (erythrocytes). The cells of the hematopoietic (blood-forming) system in the bone marrow do so upon receipt of a signal by a hormone called erythropoietin, or Epo for short. This hormone is produced mainly by the kidney that increases the Epo level by up to a thousand-fold as a response to falling oxygen saturation of the blood.

The hematopoietic cells receive the Epo signal through Epo receptors on their surface. How do the blood progenitor cells that carry only few receptor molecules manage to react adequately to a high rise in the Epo level and to always provide the required amount of red blood cells? "If too much of the hormone floods too few receptor molecules, we would expect the saturation point to be reached soon. This would mean that the hematopoietic cell can no longer respond to a further increase in the hormone level," says Dr. Ursula Klingmller of DKFZ.

Researchers in her department, who participate in the Helmholtz Alliance for Systems Biology and the MedSys Network LungSys funded by the Federal Ministry of Education and Research (BMBF), collaborated with colleagues of a working group headed by Professor Jens Timmer at Freiburg University to find out how hematopoietic cells can react in a linear way if Epo levels increase by several orders of magnitude. To do so, the researchers combined experimental data with mathematical models in a systems biology approach.

The research team was able to show that after binding of Epo to its receptor both molecules are rapidly taken up into the interior of the hematopoietic cells where they are broken down. During the process, the cell surface is continuously equipped with newly synthesized receptor molecules that are supplied from intracellular storage places. "This turnover of receptor molecules is a very rapid process," Jens Timmer explains who is a member of the Freiburg Institute for Advances Studie
'/>"/>

Contact: Dr. Sibylle Kohlstaedt
s.kohlstaedt@dkfz.de
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Suntricity Power Stations Report Nearly 100% Percent Uptime Suntricity Power Stations using AC power more reliable than standard sun powered solar systems
2. Harmony Information Systems Selected to Present at Exclusive MAVA Capital Connection 2010 Event
3. Flexible Assembly Systems Announces Torque Screwdriver Application Guide
4. Economic Recovery and New Healthcare Legislation: The Stars Are Aligned for Increased Adoption of HR Management Systems (HRMS)
5. Proximity Systems Announces First Large Sale of New LAN Based Electronic Lock Management System; Completion of Four Pilot Installations
6. Harmony Information Systems to Host Free Webcast: Learn How Vermont and Pennsylvania Are Taking Control of Medicaid Waivers Management
7. Impact Systems Successfully Completes EMC Documentum Migration for Global Pharmaceutical Client
8. New Diagnostic Testing Company, Blue Ocean Biomedical, Specializes In Automated, Load & Go Cell Analysis Systems For Immune Monitoring
9. Harmony Information Systems Announces Availability of Harmony for Aging Waivers Edition
10. Harmony Information Systems Offers Free eCards to Celebrate Older Americans Month
11. Clone Systems, Inc. Updates PCI Solutions for Level 1 & 2 Merchants
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... Search Engine Optimization is needed ... of search engines and get more audience and ... compared many Linux hosting suppliers and announced that ... most recommended Linux hosting suppliers for webmasters from ... buy high quality Linux hosting (including VPS and ...
(Date:8/22/2014)... 2014 Deep Research Report on ... in-depth research report on the Glucose Meter market. ... Glucose Meter definition, classification, application, and industry chain ... covers the international market analysis, including domestic market ... environment & economic situation analysis. The report on ...
(Date:8/22/2014)... 23, 2014 Recently, Skmen.com, an experienced ... of 2014 bohemian dresses in its online store. Moreover, ... prices, up to 28% off. All the international clients ... August 31, 2014. , The company’s professional online ... to show worldwide customers more the latest information about ...
(Date:8/22/2014)... August 22, 2014 AWeber, one ... that currently helps more than 120,000 small businesses ... the attention of Shane Michaels, prompting an investigative review. ... element for any online marketing campaign, despite what some ... the marketing world,” reports Michaels. “AWeber is a great ...
(Date:8/22/2014)... Vegas, NV (PRWEB) August 22, 2014 ... content that is written by marketing experts for marketers ... affiliate links has caught the attention of Shane Michaels, ... involved with Internet marketing in any way knows that ... failure in the industry,” reports Michaels. “But even though ...
Breaking Medicine News(10 mins):Health News:Top10BestSEOHosting.com Announces Best Cheap Hosting Suppliers Of This Summer 2Health News:Glucose Meter Industry Global (Europe, Asia, NA, ROW) Analysis Now Available at ReportsnReports.com 2Health News:Glucose Meter Industry Global (Europe, Asia, NA, ROW) Analysis Now Available at ReportsnReports.com 3Health News:Cheap Bohemian Dresses Unveiled by Experienced Supplier Skmen.com 2Health News:AWeber: Review Exposes Affordable Provider of Opt-In Email Marketing Services 2Health News:My Writers: Review Exposes Online Source for Quality Marketing Content 2
... just more but sicker residents, , THURSDAY, Dec. 31 (HealthDay ... nation,s health-care system is not prepared to deal with the ... baby-boom generation are about to turn 65. And in the ... 65 will double, according to a report on the elder ...
... , MISSION, Kan., Dec. 31 President Obama signed the bill ... With this extension, employers must act quickly to fulfill their notice ... COBRAGuard Inc. is offering a free Webinar on Wednesday, Jan. 6 ... Get it Right the First Time - Your Action Plan for ...
... , NASHVILLE, Tenn., Dec. 31 Emdeon (NYSE: ... cycle management solutions, today announced that it will make a presentation ... be held from January 11 to 14, 2010 in San Francisco, ... at 4:00 p.m. Eastern time/1:00 p.m. Pacific time on Thursday, January ...
... ... and Marketing. , ... (PRWEB) December 31, 2009 -- Bradley Kirkland, President of Stone Soup Technology (SST), has hired ... her a wealth of experience in consultative sales and will work with all potential and ...
... incentive to kick the habit? Just in time for ... age 80, smoking continues to increase one,s risk for age-related ... over 65. The American Journal of ... "The take-home message is that it,s never too late to ...
... , , Blood Supply Prioritized ... YORK, Dec. 30 New York Blood Center (NYBC) serving ... calls upon the community to please donate blood today. ... 2009, coupled with unusually high demand from regional hospitals, have ...
Cached Medicine News:Health News:As U.S. Ages, Health Care May Need to Change 2Health News:As U.S. Ages, Health Care May Need to Change 3Health News:COBRAGuard Offers Free Action Plan Webinar to Assist Employers with COBRA Subsidy Extension 2Health News:COBRAGuard Offers Free Action Plan Webinar to Assist Employers with COBRA Subsidy Extension 3Health News:Emdeon to Present at the 28th Annual J.P. Morgan Healthcare Conference 2Health News:Stone Soup Technology Hires Former Scoop Magazine Publisher Melanie Feltman 2Health News:It's never too late to quit smoking and save your vision 2Health News:Rh-Negative Blood Donors Needed Now 2Health News:Rh-Negative Blood Donors Needed Now 3
(Date:8/21/2014)... 2014  Decision Resources Group finds that, for ... Brazil and Mexico ... prescribe long-acting beta-agonist (LABA)- and long-acting muscarinic antagonist ... current severe cost/coverage constraints. Therefore, new brands of ... launch in these countries—which will considerably expand the ...
(Date:8/21/2014)... , Aug. 21, 2014 /PRNewswire-iReach/ -- ScriptPro ... Alliance (HITRUST) under its Common Security Framework (CSF). ... Security and Privacy Manager, "We appreciate this rigorous, ... of commitment that this certification signifies. Our business ... ABOUT THE CSF CERTIFICATION PROCESS: ScriptPro,s internal ...
(Date:8/21/2014)... BreedIT Corp., (OTCQB: BRDT) ... worldwide license holder and distributor of highly sophisticated ... today is pleased to announce the formation of ... a leading Israeli medical Cannabis breeder. ... breeds of medical Cannabis to meet the requests ...
Breaking Medicine Technology:Novel Fixed-Dose Combinations for COPD in Brazil and Mexico Will Compete With Well-Established Therapies in an Environment Dominated by Aggressive Cost-Control Mechanisms 2Novel Fixed-Dose Combinations for COPD in Brazil and Mexico Will Compete With Well-Established Therapies in an Environment Dominated by Aggressive Cost-Control Mechanisms 3ScriptPro Achieves HITRUST Certification 2BreedIT Ltd. and Seach Ltd. Form KanaboSeed to Develop New Medical Cannabis Varieties 2BreedIT Ltd. and Seach Ltd. Form KanaboSeed to Develop New Medical Cannabis Varieties 3BreedIT Ltd. and Seach Ltd. Form KanaboSeed to Develop New Medical Cannabis Varieties 4
... India, and MISSISSAUGA, Ontario, April 1, 2011 Promius ... RDY ), and Valeant Pharmaceuticals International, Inc. ... announced that they have signed a collaboration agreement for ... Pharma will make an upfront payment and pay future ...
... CINCINNATI, April 1, 2011 CarePoint Partners, one of ... in the United States, launched a food drive today ... the less fortunate in the communities where it operates. ... conducted throughout the month of April. CarePoint Partners is ...
Cached Medicine Technology:Promius Pharma and Valeant Form Collaboration to Market Cloderm® Cream in the United States 2Promius Pharma and Valeant Form Collaboration to Market Cloderm® Cream in the United States 3Promius Pharma and Valeant Form Collaboration to Market Cloderm® Cream in the United States 4CarePoint Partners Kicks Off Food Drive to Help Fight Hunger in Twenty-One Local Communities 2
Titanium. Straight shafts with 6 mm platform and Pierse tips. Flat serrated handle with dull finish....
0.5 mm, 1 x 2 teeth set at 45 degrees. Serrated handle with polished finish....
5 mm tying platform, serrated cross action handle with polished finish. Teeth: 0.10 mm, 1 x 2 set at 90 degrees....
0.12 mm, 1 x 2 teeth. Serrated handle with polished finish....
Medicine Products: