Navigation Links
Systemic sclerosis complications more severe in African Americans than Caucasians
Date:5/9/2012

African Americans have more severe complications from systemic sclerosis, also known as scleroderma, than Caucasians. Findings published today in, Arthritis & Rheumatism, a journal of the American College of Rheumatology (ACR), show that compared with Caucasians, African-American patients were more likely to have antibodies that increased frequency and severity of pulmonary fibrosis, which is associated with decreased survival.

According to the ACR there are 49,000 adult American diagnosed with systemic sclerosisan autoimmune disease where collagen build-ups in the skin and organs, causing the skin to harden, joint pain, breathing issues, and digestive problems. Medical evidence has confirmed that African Americans have an increased incidence and worse prognosis with systemic sclerosis than Caucasians. Previous research has shown that genetic differences among the races contribute to differences in auto-antibodies, which influence how the disease affects patients.

To understand how auto-antibodies affect systemic sclerosis in African-American and Caucasian patients, a research team led by Dr. Virginia Steen from Georgetown University Medical Center in Washington, DC, analyzed data from the Pittsburgh Scleroderma Database. This database includes demographic, clinical, autoantibody, organ involvement and survival information for 203 African-American and 2945 Caucasian scleroderma patients seen at the University of Pittsburgh Medical Center between 1972 and 2007.

Findings show that African Americans had higher frequencies of certain scleroderma-specific autoantibodies compared to Caucasians: anti-U3-RNP (40% vs. 2%), U1-RNP (16% vs. 7%) and anti-topoisomerase (27% vs. 21%). Anti-topoisomerase auto-antibodies in scleroderma are associated with a higher incidence of pulmonary fibrosis (scarring of the lungs) and greater disease severity, and in this study, African-American patients with this antibody had more frequent and more severe fibrosis than the Caucasians with this antibody. Pulmonary fibrosis was also more severe in African American patients with anti-U1 RNP auto-antibodies compared to Caucasian patients with this antibody but a difference in survival between the races was not apparent. Researchers determined that the auto-antibody anti-U3 RNP was linked to more severe gastrointestinal involvement in African Americans compared to Caucasians.

Pulmonary disease is the most common cause of scleroderma related deaths, and African-American race was independently associated with pulmonary fibrosis and African Americans are at greater risk for severe lung disease, which the authors suggest may be due to genetics or environmental factors. "Our findings confirm that more serious complications affect African Americans with system sclerosis than Caucasians," concludes Dr. Steen. "For African-American systemic sclerosis patients with severe lung disease, more aggressive treatment early on could improve their outcome."


'/>"/>
Contact: Dawn Peters
healthnews@wiley.com
781-388-8408
Wiley-Blackwell
Source:Eurekalert

Related medicine news :

1. New research finds no association between white potato consumption (baked, boiled mashed) and obesity, Type 2 diabetes or systemic inflammation
2. Rare medical phenomenon of systemic tumor disappearance following local radiation treatment reported in a patient with metastatic melanoma
3. Study suggests systemic sclerosis is an independent risk factor for atherosclerosis
4. Improved protocols for contrast agents eliminates new cases of nephrogenic systemic fibrosis
5. Chinese systemic lupus erythematosus data reveal differences in epidemiology across continents
6. Genealogy may affect clinical differences in systemic lupus erythmatosus patients
7. New promising therapy against systemic sclerosis
8. New, National Amnesty International Report Finds Appalling U.S. Death Rate for Women Having Babies, Systemic Failures and Shocking Disparities in Maternal Health Care System; Tennessee is 38th Among All States in Maternal Mortality
9. New, National Amnesty International Report Finds Appalling U.S. Death Rate for Women Having Babies, Systemic Failures and Shocking Disparities in Maternal Health Care System; New Jersey is 35th Among All States in Maternal Mortality
10. New, National Amnesty International Report Finds Appalling U.S. Death Rate for Women Having Babies, Systemic Failures and Shocking Disparities in Maternal Health Care System; California 35th Among All States in Maternal Mortality
11. New, National Amnesty International Report Finds Appalling U.S. Death Rate for Women Having Babies, Systemic Failures and Shocking Disparities in Maternal Health Care System; North Carolina is 37th Among All States in Maternal Mortality
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/25/2016)... CA (PRWEB) , ... May 25, 2016 , ... "FCPX ... the quality of your footage," said Christina Austin - CEO of Pixel Film Studios. ... editors can quickly and easily add stylish color grades to their footage. A LUT ...
(Date:5/25/2016)... (PRWEB) , ... May 25, 2016 , ... Consumer access ... In early June 2016, Kashi®, a maker of whole grain cereals and other plant-based ... Certified Transitional ingredient: hard red winter wheat processed by Hesco/Dakota Organic Products. , ...
(Date:5/25/2016)... ... , ... Stern Environmental Group , of Secaucus, New Jersey, working in ... Stern’s Real Time Monitoring (RTM) Device. Stern Environmental Group will sell the first ... for use in dormitories, shelters, and nursing homes for real time bedbug monitoring in ...
(Date:5/24/2016)... ... May 24, 2016 , ... Sterling Global Products is launching ... and patented refillable hanging wipe dispenser. The campaign kick-off video is located via this ... June 25, 2016. The goal is to raise $1,000 per day for a total ...
(Date:5/24/2016)... ... May 24, 2016 , ... To better understand the impact ... award to examine gender differences in lung cancer. Today, the Lung Association announced Sharad ... Cancer in Women Award, funded by the American Lung Association’s LUNG FORCE initiative, which ...
Breaking Medicine News(10 mins):
(Date:5/23/2016)... May 23, 2016 According ... Share, Development, Growth and Demand Forecast to 2022 ... Other), by Application (Drug Discovery and Development, Proteomics, ... (Pharmaceuticals, Life Science and Biotechnology, Academic and Research ... Research, the global mass spectrometry market ...
(Date:5/23/2016)... May 23, 2016 Experts from ... Precision Medicine and the role of technology in ... The First International Conference of VPS-Penn Medicine opened ... patronage and presence of Sheikh Nahyan bin Mubarak Al Nahyan, ... Precision Medicine, which helps provide personalized medicine and tailor-made healthcare ...
(Date:5/22/2016)... DS Biopharma (DS) today ... compound DS102 in chronic obstructive pulmonary disease (COPD) ... patients. Recent DS preclinical data suggests ... and has bronchodilatory, anti-inflammatory and anti-fibrotic properties in ... will publish further detail on these findings later ...
Breaking Medicine Technology: