Navigation Links
Systemic sclerosis complications more severe in African Americans than Caucasians
Date:5/9/2012

African Americans have more severe complications from systemic sclerosis, also known as scleroderma, than Caucasians. Findings published today in, Arthritis & Rheumatism, a journal of the American College of Rheumatology (ACR), show that compared with Caucasians, African-American patients were more likely to have antibodies that increased frequency and severity of pulmonary fibrosis, which is associated with decreased survival.

According to the ACR there are 49,000 adult American diagnosed with systemic sclerosisan autoimmune disease where collagen build-ups in the skin and organs, causing the skin to harden, joint pain, breathing issues, and digestive problems. Medical evidence has confirmed that African Americans have an increased incidence and worse prognosis with systemic sclerosis than Caucasians. Previous research has shown that genetic differences among the races contribute to differences in auto-antibodies, which influence how the disease affects patients.

To understand how auto-antibodies affect systemic sclerosis in African-American and Caucasian patients, a research team led by Dr. Virginia Steen from Georgetown University Medical Center in Washington, DC, analyzed data from the Pittsburgh Scleroderma Database. This database includes demographic, clinical, autoantibody, organ involvement and survival information for 203 African-American and 2945 Caucasian scleroderma patients seen at the University of Pittsburgh Medical Center between 1972 and 2007.

Findings show that African Americans had higher frequencies of certain scleroderma-specific autoantibodies compared to Caucasians: anti-U3-RNP (40% vs. 2%), U1-RNP (16% vs. 7%) and anti-topoisomerase (27% vs. 21%). Anti-topoisomerase auto-antibodies in scleroderma are associated with a higher incidence of pulmonary fibrosis (scarring of the lungs) and greater disease severity, and in this study, African-American patients with this antibody had more frequent and more severe fibrosis than the Caucasians with this antibody. Pulmonary fibrosis was also more severe in African American patients with anti-U1 RNP auto-antibodies compared to Caucasian patients with this antibody but a difference in survival between the races was not apparent. Researchers determined that the auto-antibody anti-U3 RNP was linked to more severe gastrointestinal involvement in African Americans compared to Caucasians.

Pulmonary disease is the most common cause of scleroderma related deaths, and African-American race was independently associated with pulmonary fibrosis and African Americans are at greater risk for severe lung disease, which the authors suggest may be due to genetics or environmental factors. "Our findings confirm that more serious complications affect African Americans with system sclerosis than Caucasians," concludes Dr. Steen. "For African-American systemic sclerosis patients with severe lung disease, more aggressive treatment early on could improve their outcome."


'/>"/>
Contact: Dawn Peters
healthnews@wiley.com
781-388-8408
Wiley-Blackwell
Source:Eurekalert

Related medicine news :

1. New research finds no association between white potato consumption (baked, boiled mashed) and obesity, Type 2 diabetes or systemic inflammation
2. Rare medical phenomenon of systemic tumor disappearance following local radiation treatment reported in a patient with metastatic melanoma
3. Study suggests systemic sclerosis is an independent risk factor for atherosclerosis
4. Improved protocols for contrast agents eliminates new cases of nephrogenic systemic fibrosis
5. Chinese systemic lupus erythematosus data reveal differences in epidemiology across continents
6. Genealogy may affect clinical differences in systemic lupus erythmatosus patients
7. New promising therapy against systemic sclerosis
8. New, National Amnesty International Report Finds Appalling U.S. Death Rate for Women Having Babies, Systemic Failures and Shocking Disparities in Maternal Health Care System; Tennessee is 38th Among All States in Maternal Mortality
9. New, National Amnesty International Report Finds Appalling U.S. Death Rate for Women Having Babies, Systemic Failures and Shocking Disparities in Maternal Health Care System; New Jersey is 35th Among All States in Maternal Mortality
10. New, National Amnesty International Report Finds Appalling U.S. Death Rate for Women Having Babies, Systemic Failures and Shocking Disparities in Maternal Health Care System; California 35th Among All States in Maternal Mortality
11. New, National Amnesty International Report Finds Appalling U.S. Death Rate for Women Having Babies, Systemic Failures and Shocking Disparities in Maternal Health Care System; North Carolina is 37th Among All States in Maternal Mortality
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/19/2019)... ... August 19, 2019 , ... ProRehab Louisville and Dr. Stacie Grossfeld have ... and to access to top-notch sports medical care and sport injury experts for rehabilitation. ... demands of ice skating, knows the individualized treatment plan, and understands what a triple ...
(Date:8/19/2019)... ... 19, 2019 , ... Cosmetic Town, an online plastic surgery and information community ... in New York currently providing a lifetime of natural looking results for patients with ... hair. Cosmetic Town makes the process of finding information about these board-certified surgeons in ...
(Date:8/17/2019)... Fla. (PRWEB) , ... August 17, 2019 , ... ... Annual List of America’s Fastest-Growing Private Companies—the Inc. 5000 , For the 2nd ... 2098 With Three-Year Revenue Growth of 192% Percent , Inc. magazine today revealed ...
(Date:8/16/2019)... ... 16, 2019 , ... The clinical trial supply chain landscape is constantly shifting, ... Join Just In Time Manufacturing Solutions Manager at Almac Clinical Services , Natalie ... EDT (4pm BST/UK) on a journey through time as it relates to clinical trial ...
(Date:8/16/2019)... ... August 16, 2019 , ... Dr. Demetri ... the esteemed Haute Beauty Network. , The Haute Beauty Network, well known for ... Arnaoutakis as a hair restoration expert and our newest addition to the Haute ...
Breaking Medicine News(10 mins):
(Date:8/19/2019)... ... August 19, 2019 , ... ... centers, today announced the findings of research validating the clinical impact of MedAware’s ... were published 7 August 2019 in the Journal of American Medical Informatics ...
(Date:8/19/2019)... ... August 19, 2019 , ... ... Khoury, M.D., will join its Richardson, Texas location, starting Monday, Sep. 2nd. , ... Anesthesiology with a subspecialty board certification in pain management. , Dr. Khoury attended ...
(Date:8/17/2019)... ... 2019 , ... The American Legion Dorchester Post 91 in Cambridge, Md., donated ... the benefit of veteran patients, adding to a donation in the same amount it ... most recent donation from Post 91 will enable the VA Maryland Health Care System ...
Breaking Medicine Technology: