Navigation Links
System that predicts protein structures could help researchers design drugs
Date:5/18/2010

COLUMBIA, Mo. The National Institute of General Medical Sciences (NIGMS) of the National Institutes of Health (NIH) recently granted University of Missouri researchers $1.18 million to further develop and improve their protein prediction software system called MULTICOM. Using this system to understand protein structures in diseases can help scientists design drugs for a variety of diseases.

"Proteins are fundamental molecules that are involved in many basic and important functions," said Jianlin Cheng, assistant professor of computer science in the MU College of Engineering. "The structure of a protein determines the function. When a protein folds abnormally, dysfunctions occur, which lead to diseases, such as Parkinson's disease, Alzheimer's and cancer. By converting protein sequences into predictable structures, scientists can view how a structure folds and thus predict how drugs will affect the protein. This information is useful when designing drugs and cures."

The current "gold standard" for protein structure determination is X-ray crystallography and nuclear magnetic resonance (NMR) spectroscopy techniques. These experimental techniques can be time consuming and expensive, Cheng said. With this grant, Cheng would attempt to develop fast and cheap computational technology to accurately predict protein structure from protein sequence.

"A lot of advances have been made since this field was developed," Cheng said. "We are able to predict high-accuracy structures for about 50 percent of proteins, but we still have a lot of room for improvement."

Every two years, scientists who are developing protein-prediction technology test their programs in the Critical Assessment of Techniques for Protein Structure Prediction (CASP), which is considered by scientists to be the "Olympics of protein prediction." During the competition, CASP organizers send protein sequences to research groups around the world, two or three proteins per working day, for a total of more than 100 proteins. Researchers must return their predictions within three days. Independent experts evaluate the submissions. Teams that score the highest are invited to give presentations at the CASP conference.

In 2008, the MU team ranked at the top in several categories at CASP8. The team is participating in CASP9 this summer from May to July.


'/>"/>

Contact: Kelsey Jackson
JacksonKN@missouri.edu
573-882-8353
University of Missouri-Columbia
Source:Eurekalert  

Related medicine news :

1. PET scanning probes reveal different cell function within the immune system
2. Centegra Health System Launches New Physician Network
3. Flexible Assembly Systems Announces Torque Screwdriver Application Guide
4. Economic Recovery and New Healthcare Legislation: The Stars Are Aligned for Increased Adoption of HR Management Systems (HRMS)
5. Proximity Systems Announces First Large Sale of New LAN Based Electronic Lock Management System; Completion of Four Pilot Installations
6. Terumo to simultaneously evaluate Misago self-expanding stent system in the United States and Japan
7. TerrAlign Selected to Join Veeva System's Veeva Web Program
8. Harmony Information Systems to Host Free Webcast: Learn How Vermont and Pennsylvania Are Taking Control of Medicaid Waivers Management
9. Impact Systems Successfully Completes EMC Documentum Migration for Global Pharmaceutical Client
10. New Diagnostic Testing Company, Blue Ocean Biomedical, Specializes In Automated, Load & Go Cell Analysis Systems For Immune Monitoring
11. Harmony Information Systems Announces Availability of Harmony for Aging Waivers Edition
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
System that predicts protein structures could help researchers design drugs
(Date:2/22/2017)... ... February 22, 2017 , ... The Waismann Method® is providing a ... have recently fallen victim to America’s opioid epidemic. Now, opiate dependent individuals can be ... are free from the shame, stigma, and harmful labeling believed to prevent ...
(Date:2/22/2017)... ... February 22, 2017 , ... The National Academy of ... with the April 2017 testing period. NACCM, a nonprofit organization, has provided the ... (CMC) exam is periodically re-calibrated to ensure that newly certified professionals are prepared ...
(Date:2/22/2017)... ... February 22, 2017 , ... Giving ... fewer trips the emergency room, fewer hospital admissions, and better blood pressure and ... Care® (AJMC®) finds. The study can be found here . , The ...
(Date:2/22/2017)... (PRWEB) , ... February 22, 2017 , ... ... adults with chronic conditions reported skipping doses or not filling a prescription because ... or under-insured, rates of cost-related problems getting medications were 30-60%*. At ...
(Date:2/22/2017)... ... , ... Doctors on Liens is continuing its steady expansion of medical specialties ... at North Valley Eye Medical Group in Mission Hills . Eye injuries and ... injury cases. These injuries have a major impact on the quality of life ...
Breaking Medicine News(10 mins):
(Date:2/22/2017)... LONDON , Feb. 22, 2017 ... protrudes through the abdominal wall due to weak ... types, namely inguinal hernia, incisional hernia, femoral hernia, ... hernia). The hernia surgeries are performed ... material with the help fixation devices. Among the ...
(Date:2/22/2017)... 2017 Summary Provides understanding and ... entered into by the worlds leading healthcare companies. ... The Global Spinal Cord Partnering Terms and Agreements since ... and agreements entered into by the world,s leading healthcare ... - Top deals by value - Deals listed ...
(Date:2/22/2017)... YORK , Feb. 22, 2017 Summary ... neurone disease partnering deals and agreements entered into by ... report: http://www.reportlinker.com/p03605682-summary/view-report.html Description The Global Motor ... provides understanding and access to partnering deals and agreements ... - Trends in partnering deals - Top ...
Breaking Medicine Technology: