Navigation Links
Synthetic molecules hold promise for new family of anti-cancer drugs
Date:6/4/2008

Jerusalem, June 4, 2008 -- Synthetic molecules designed by two Hebrew University of Jerusalem researchers have succeeded in reducing and even eliminating the growth of human malignant tissues in mice, while having no toxic effects on normal tissue.

For their work in developing these harbingers of a possible new generation of anti-cancer drugs, Dr. Arie Dagan and Prof. Shimon Gatt of the Department of Biochemistry of the Hebrew University-Hadassah Medical School were among those receiving the Kaye Award for Innovation today during the 71st meeting of the Hebrew University of Jerusalem Board of Governors.

The molecules developed by Dagan and Gatt affected the metabolism of various sphingolipids and consequently those of cancer cells. Sphingolipids are a family of complex lipid molecules that are involved in signaling pathways that mediate cell growth, differentiation and death.

Several of the most active molecules developed by Dagan and Gatt are derivatives of ceramide (a member of the sphingolipid family). Ceramide induces programmed cell death (apoptosis) in a variety of cancer cells.

The natural levels of ceramide in cancer cells are generally too low to induce a therapeutic effect. In preclinical studies to date, various treatments with the synthetic molecules resulted in an elevation of ceramide levels in cancer cells, thereby leading to their death by apoptosis. In addition, these synthetic molecules appear to be synergistic with chemotherapeutic drugs.

Dagan and Gatt state that their studies demonstrated that their synthetic compounds reduced considerably the sizes of pancreatic, prostate and breast tumors with little or no effects on normal cells and tissues. The researchers see this as a precursor to the development of a new generation of anti-cancer drugs that induce, selectively, apoptosis only to tumorous cells. These drugs are expected to be highly effective while inducing fewer side effects than current anti-cancer drugs.


'/>"/>

Contact: Jerry Barach
jerryb@savion.huji.ac.il
972-258-82904
The Hebrew University of Jerusalem
Source:Eurekalert  

Related medicine news :

1. Its Safe to Play on Desso Synthetic Turf
2. Experts Agree There is No Scientific Evidence of Health Risks in New Jersey Synthetic Turf Fields
3. Oregon study raises questions on synthetic progestins
4. Synthetic peptoids hold forth promise for new antibiotics
5. New understanding of how big molecules bind will lead to better drugs, synthetic organic materials
6. Collagen Matrix, Inc. Receives FDA 510(k) Clearance for SynOss(TM) Synthetic Mineral Bone Graft Material
7. Varian, Inc. Offers New Products for the Rapid Purification of Synthetic Oligonucleotides.
8. Duramed Launches New Indication for ENJUVIA(TM) (Synthetic Conjugated Estrogens, B) at North American Menopause Society Annual Meeting
9. Study in mice suggests molecules in plants have beneficial effect on Alzheimers disease
10. Molecules that changed the world
11. Allergic response tied to lipid molecules in cell membrane
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Synthetic molecules hold promise for new family of anti-cancer drugs
(Date:5/31/2016)... York, New York (PRWEB) , ... May 31, 2016 , ... ... effects research to provide the best accessories to avoid excessive Smartphone radiation implicated in ... of the study released on the bioRxiv preprint server on May 26th ...
(Date:5/31/2016)... Barbara, CA (PRWEB) , ... May 31, 2016 , ... Throughout the day, adults often ... for sustained motivation and awareness, but what they could be reaching for instead is a ... tea plants that are grown in Japan. This sacred tea is harvested from early June ...
(Date:5/31/2016)... ... May 31, 2016 , ... St. Joseph Medical Center ... information exchange, which enables physicians at SJMC’s two hospital campuses, downtown and in ... organizations in the exchange. SJMC’s membership in the health information exchange underscores the ...
(Date:5/31/2016)... , ... May 31, 2016 , ... DDL, Inc. announced ... Association for Laboratory Accreditation (A2LA) to include ISO 594-1 and ISO 594-2 testing for ... of achieving a leak-free connection between two medical devices (e.g. a syringe and hypodermic ...
(Date:5/31/2016)... (PRWEB) , ... May 31, 2016 , ... The successful ... model in their laboratories as well. However, laboratories have different challenges compared to manufacturing ... of lean operations in the lab, METTLER TOLEDO has developed the Lean Lab ...
Breaking Medicine News(10 mins):
(Date:5/31/2016)... The global dental bone graft ... CAGR of 10.6% within a forecast period from 2014 ... in 2013. Owing to favorable factors at play in ... by the end of this forecast period, i.e. 2020. ... representation in a research report published by Transparency Market ...
(Date:5/31/2016)... , May 31, 2016 ... and Annotate Content From Elsevier,s ScienceDirect Database ... scientific, technical and medical information products and services, ... Berlin -based scientific collaboration platform PaperHive to enable ... over 12 million articles on ScienceDirect , ...
(Date:5/31/2016)... May 31, 2016 , Isansys  Lifecare, ... its Patient Status Engine wireless patient monitoring platform, as it ... Germany , Scotland and ... 2 nd generation system, launched earlier this year, is now ... , , This new technology significantly enhances ...
Breaking Medicine Technology: