Navigation Links
Synthetic molecules hold promise for new family of anti-cancer drugs
Date:6/4/2008

Jerusalem, June 4, 2008 -- Synthetic molecules designed by two Hebrew University of Jerusalem researchers have succeeded in reducing and even eliminating the growth of human malignant tissues in mice, while having no toxic effects on normal tissue.

For their work in developing these harbingers of a possible new generation of anti-cancer drugs, Dr. Arie Dagan and Prof. Shimon Gatt of the Department of Biochemistry of the Hebrew University-Hadassah Medical School were among those receiving the Kaye Award for Innovation today during the 71st meeting of the Hebrew University of Jerusalem Board of Governors.

The molecules developed by Dagan and Gatt affected the metabolism of various sphingolipids and consequently those of cancer cells. Sphingolipids are a family of complex lipid molecules that are involved in signaling pathways that mediate cell growth, differentiation and death.

Several of the most active molecules developed by Dagan and Gatt are derivatives of ceramide (a member of the sphingolipid family). Ceramide induces programmed cell death (apoptosis) in a variety of cancer cells.

The natural levels of ceramide in cancer cells are generally too low to induce a therapeutic effect. In preclinical studies to date, various treatments with the synthetic molecules resulted in an elevation of ceramide levels in cancer cells, thereby leading to their death by apoptosis. In addition, these synthetic molecules appear to be synergistic with chemotherapeutic drugs.

Dagan and Gatt state that their studies demonstrated that their synthetic compounds reduced considerably the sizes of pancreatic, prostate and breast tumors with little or no effects on normal cells and tissues. The researchers see this as a precursor to the development of a new generation of anti-cancer drugs that induce, selectively, apoptosis only to tumorous cells. These drugs are expected to be highly effective while inducing fewer side effects than current anti-cancer drugs.


'/>"/>

Contact: Jerry Barach
jerryb@savion.huji.ac.il
972-258-82904
The Hebrew University of Jerusalem
Source:Eurekalert  

Related medicine news :

1. Its Safe to Play on Desso Synthetic Turf
2. Experts Agree There is No Scientific Evidence of Health Risks in New Jersey Synthetic Turf Fields
3. Oregon study raises questions on synthetic progestins
4. Synthetic peptoids hold forth promise for new antibiotics
5. New understanding of how big molecules bind will lead to better drugs, synthetic organic materials
6. Collagen Matrix, Inc. Receives FDA 510(k) Clearance for SynOss(TM) Synthetic Mineral Bone Graft Material
7. Varian, Inc. Offers New Products for the Rapid Purification of Synthetic Oligonucleotides.
8. Duramed Launches New Indication for ENJUVIA(TM) (Synthetic Conjugated Estrogens, B) at North American Menopause Society Annual Meeting
9. Study in mice suggests molecules in plants have beneficial effect on Alzheimers disease
10. Molecules that changed the world
11. Allergic response tied to lipid molecules in cell membrane
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Synthetic molecules hold promise for new family of anti-cancer drugs
(Date:9/22/2017)... HOUSTON, Texas (PRWEB) , ... September 22, 2017 ... ... leading network of independent freestanding emergency rooms is celebrating the one year anniversary ... anniversary of our facility opening,” said Dr. Otinwa, Facility Medical Director of First ...
(Date:9/22/2017)... ... September 22, 2017 , ... Silicon ... effectively even on the go. Their electric toothbrushes aggressively attack oral bacteria by ... UV sanitizing technology. Combining leading edge Enke technology with a premium timeless design, ...
(Date:9/22/2017)... ... ... “Letters From Home”: a moving compilation of letters that remind readers of ... Home” is the creation of published author, John Allred, a passionate leader of ministry ... International, who has traveled and ministered on four continents. , “It is my hope ...
(Date:9/22/2017)... ... September 22, 2017 , ... ... create life. Although frozen embryos have a slight statistical advantage for live births, ... is a wonderful opportunity for women undergoing medical treatment or who are concerned ...
(Date:9/21/2017)... (PRWEB) , ... September 21, 2017 , ... With ProSlideshow ... fun and easy to do. Users can select from up to two layers of ... a click of a mouse all within Final Cut Pro X. , ...
Breaking Medicine News(10 mins):
(Date:9/19/2017)... a venture-backed medical device company developing a non-invasive, robotically assisted, platform therapy that uses pulsed ...   ... Jim Bertolina, ... Tom Tefft ... medical device executive Josh Stopek , PhD, who has led R&D and business development ...
(Date:9/18/2017)... Mich. , Sept. 18, 2017  PMD Healthcare ... Specialty Pharmacy of Kalamazoo, Mich. , ... hub service that expedites and streamlines patient and provider ... PD 2.0, and wellness management services.  ... device used to measure lung function for a variety ...
(Date:9/13/2017)... 2017   OrthoAtlanta has been named the official ... Committee (AFHC) for the 2018 College Football Playoff (CFP) National ... Mercedes-Benz Stadium in Atlanta, Georgia . OrthoAtlanta ... In" campaign, participating in many activities leading up to, and ... ...
Breaking Medicine Technology: