Navigation Links
'Synthetic lethality' strategy improves molecularly targeted cancer therapy
Date:9/21/2010

PHILADELPHIA (September 21, 2010)Molecularly targeted therapies can reduce tumors rapidly. However, not all tumors respond to the drugs, and even those that do often develop resistance over time. Looking for a way to combat the problem of resistance, researchers at Fox Chase Cancer Center hypothesized that hitting already weakened cancer cells with a second targeted agent could kill thembut only if it was the right second agent.

One well-validated molecular target for anti-cancer drugs is the epidermal growth factor receptor, or EGFR. Using a novel screening approach, investigators in the Fox Chase Developmental Therapeutics Program identified over 60 additional proteins that are necessary for cells to survive in the presence of an EGFR inhibitor. When they simultaneously blocked the EGFR inhibitors and any one of these other proteins, more of the cancer cells died. The researchers say this screening strategy to identify targets for effective combinations of cancer drugs will open the door for future therapies. Already, two clinical trials are under way to test innovative drug combinations suggested by the new tactic.

"We found that knocking out one or the other target doesn't have a major effect, but knocking out both increases tumor cell death," says Igor Astsaturov, M.D., Ph.D., an assistant professor and medical oncologist at Fox Chase. Astsaturov led the study, which will be published in the September 21, 2010 issue of Science Signaling.

To identify additional targets that would boost the effectiveness of EGFR inhibitors against cancer, Astsaturov and colleagues screened only proteins that interact directly or indirectly with EGFR. The team mined the literature and built a candidate set of 638 EGFR-interacting proteins. They then used an experimental technique called small inhibitory RNA (siRNA) systematically to block activity of each of the genes in cancer cells that had been treated with an EGFR inhibitor. In doing so
'/>"/>

Contact: Diana Quattrone
Diana.Quattrone@fccc.edu
215-728-7784
Fox Chase Cancer Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Biosynthetic Corneas Show Promise in Transplants
2. Surf Sweets Among Few Candy Offerings Free of Synthetic Dyes Despite Growing Consumer Concern Over Affect on Children
3. Synthetic eye prosthesis
4. Chemo Plus Synthetic Drug Shrunk Pancreatic Tumors
5. Chemotherapy plus synthetic compound provides potent anti-tumor effect in pancreatic cancers
6. Strategy discovered to prevent Alzheimers-associated traffic jams in the brain
7. Radiologists call for national strategy to address medical imaging overuse
8. HIV care providers and researchers applaud release of national HIV/AIDS strategy
9. HIV prevention strategy key to curbing epidemic and cutting long-term treatment costs
10. Larry Watkins Joins QualEDIx as Executive Vice President, Healthcare Strategy and Business Development
11. Internists outline comprehensive federal strategy to control tobacco use
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/27/2015)... Beckman Coulter is sponsoring a ... the evolution of neural circuitry and swimming behavior of ... mechanisms by which analogous forms of swimming behavior, such ... independently in certain sea slug clades. The webinar is ... 30, 2015 at 8:00am PT. , Sea slugs (Mollusca, ...
(Date:4/27/2015)... April 27, 2015 Sitting or standing for ... and feel tired, and for those whose occupation requires them ... and taxi cab drivers, or to be on their feet ... the discomfort can be more severe and longer lasting. These ... syndrome. Dr. Madaiah Revana of Northeast Houston Vein Center is ...
(Date:4/27/2015)... 27, 2015 FMC Corporation’s Health and ... wide range of market leading ingredients and solutions at ... Geneva, Switzerland. Vitafoods Europe 2015 expects to host 14,000 ... the latest research in such areas as digestive health, ... FMC Health and Nutrition’s booth will feature its world ...
(Date:4/27/2015)... 27, 2015 Telematics Berlin is Europe’s ... suppliers, associations, CE players and the government to discuss ... to the car. This year’s panel on connected car ... the European Commission, is an opportunity to hear and ... a European Automotive Security Standard for years to come. ...
(Date:4/27/2015)... Mirada, CA (PRWEB) April 27, 2015 ... minimally invasive treatments for nail fungi and infections. Onychomycosis, ... to affect up to 10% of adults in the ... fragility, and irregularity in thickness. , Healthpointe’s ... Institute , a branch dedicated to providing quality skincare ...
Breaking Medicine News(10 mins):Health News:Beckman Coulter Genomics Presents Using Next-Gen Sequencing to Study the Evolution of Neural Circuitry 2Health News:Beckman Coulter Genomics Presents Using Next-Gen Sequencing to Study the Evolution of Neural Circuitry 3Health News:Northeast Houston Vein Center Offers Tips on How to Treat Achy Legs 2Health News:Northeast Houston Vein Center Offers Tips on How to Treat Achy Legs 3Health News:FMC Health and Nutrition to Feature Epax® Brand Omega-3 Ingredients at Vitafoods Europe 2015 2Health News:Telematics Berlin: European Commission discuss a pan European Automotive Security Strategy 2Health News:Telematics Berlin: European Commission discuss a pan European Automotive Security Strategy 3Health News:Southern California Healthpointe Clinics Now Treating Nail Fungus 2
... offered to manufacture an antiviral drug for bird flu called ... It has already made Tamiflu in its lab. // , ... popular as Tamiflu has but is cheaper and sometimes a ... Cipla in a press release said:‘‘Zanamivir is the only other ...
... as the first most common cause for death in ... stress echocardiography that can help predict life-threatening heart problems ... conducted among a group of diabetic women aged between ... type of stress test for suspected coronary disease that ...
... an increasing attention is being directed towards cost-effective treatment ... chiropractic care produces significantly // better outcomes when compared ... higher pain relief and satisfaction and lower disability scores ... ,The study has been conducted in the American population ...
... a hand-held scope called VELscope, which has been developed by ... of Dental Craniofacial Research. The devise emits a blue light ... detection of cancerous lesions in the mouth. The VELscope would ... better treatment is achieved when oral cancer is treated in ...
... Livermore National Laboratory are studying the biopolymer structural dynamics ... The new theory on protein folding unfolds the mystery ... leads to diseases and the study is to be ... of Sciences. , ,The researchers used a technique ...
... sclerosis patients in Britain can look forward to some relief, ... for the first time, following approval from the Home Office ... Britain will soon be able to obtain an unlicensed, cannabis-based ... arthritis even though it is yet to be licensed in ...
Cached Medicine News:Health News:Cipla In India Can Manufacture Drug For Bird Flu 2Health News:Cipla In India Can Manufacture Drug For Bird Flu 3Health News:A Simple Test To Detect Heart Disease In Women Can Be Lifesaving 2Health News:Back Pain Can Now Be Cost-Effectively Treated By Chiropractic Care 2Health News:Relief For British MS Patients: Cannabis-Based Oral Spray 2
(Date:4/27/2015)... MILAN , April 27, 2015  USL di ... Italian province of Reggio Emilia, has implemented Zebra ... throughout the hospital. The Wireless Network Solution ... patients, medical records securely and in real time via ... available at all times. Zebra also provides employee and ...
(Date:4/27/2015)... SAN DIEGO , April 27, 2015  Agena Bioscience ... (CSP) for Agena Bioscience,s MassARRAY platform in China ... at unprecedented speed. It is a hotbed for practical, meaningful ... China and for the rest of the world. ... community in China ," said Peter ...
(Date:4/27/2015)... -- China Jo-Jo Drugstores, Inc. (NASDAQ CM: ... leading China-based retail and wholesale distributor that offers pharmaceutical ... pharmacies, today announced its subsidiary, Hangzhou Jiuzhou Grand Pharmacy ... sales incentive agreement with Wyeth Pharmaceutical Company, Ltd. ("Wyeth"), ... of Pfizer Inc. (NYSE: PFE ) (the ...
Breaking Medicine Technology:Zebra Technologies' Wireless Solutions Help Reggio Emilia Hospital Staff Improve Patient Care and Reduce Costs 2Zebra Technologies' Wireless Solutions Help Reggio Emilia Hospital Staff Improve Patient Care and Reduce Costs 3Zebra Technologies' Wireless Solutions Help Reggio Emilia Hospital Staff Improve Patient Care and Reduce Costs 4Zebra Technologies' Wireless Solutions Help Reggio Emilia Hospital Staff Improve Patient Care and Reduce Costs 5Agena Bioscience Names Bioyong Technology as Fifth Certified Service Provider in China 2China Jo-Jo Drugstore Signed a New Sales Incentive Agreement with Wyeth Pharmaceutical, a Subsidiary of Pfizer 2China Jo-Jo Drugstore Signed a New Sales Incentive Agreement with Wyeth Pharmaceutical, a Subsidiary of Pfizer 3China Jo-Jo Drugstore Signed a New Sales Incentive Agreement with Wyeth Pharmaceutical, a Subsidiary of Pfizer 4
... Disease Week ... 2008, ... today that it has initiated the Phase 2 clinical,development program of MDX-1100, ... ulcerative colitis (UC) and,rheumatoid arthritis (RA). MDX-1100 could potentially treat UC and ...
... Thailand, May 9 An emergency,veterinary team from the ... stand-by in Thailand awaiting authority to enter cyclone struck,Myanmar ... of animals,that human survivors depend on for food and ... The Food and Agriculture,Organization of the United Nations (FAO) ...
Cached Medicine Technology:Medarex Announces Initiation of Phase 2 Clinical Trials for the Treatment of Ulcerative Colitis and Rheumatoid Arthritis 2Medarex Announces Initiation of Phase 2 Clinical Trials for the Treatment of Ulcerative Colitis and Rheumatoid Arthritis 3Medarex Announces Initiation of Phase 2 Clinical Trials for the Treatment of Ulcerative Colitis and Rheumatoid Arthritis 4Animals That Cyclone Survivors Depend on Need Help Now 2
Inquire...
Inquire...
Inquire...
The modular, high-end stereomicroscope; meets even the most critical demands in research and quality control provides high-contrast images with excellent depth of field and color fidelity...
Medicine Products: