Navigation Links
Synthetic Red Blood Cells Developed
Date:12/14/2009

Soft and synthetic red-blood-cell-like particles carry oxygen, drugs, and more…

Santa Barbara, California (Vocus) -- Scientists at UC Santa Barbara, in collaboration with scientists at University of Michigan, have developed synthetic particles that closely mimic the characteristics and key functions of natural red blood cells, including softness, flexibility, and the ability to carry oxygen.

The primary function of natural red blood cells is to carry oxygen, and the synthetic red blood cells (sRBCs) do that very well, retaining 90% of their oxygen-binding capacity after a week. The sRBCs also, however, have been shown to deliver therapeutic drugs effectively and with controlled release, and to carry well-distributed contrast agents for enhanced resolution in diagnostic imaging.

“This ability to create flexible biomimetic carriers for therapeutic and diagnostic agents really opens up a whole new realm of possibilities in drug delivery and similar applications,” noted UCSB chemical engineering professor Samir Mitragotri. “We know that we can further engineer sRBCs to carry additional therapeutic agents, both encapsulated in the sRBC and on its surface.”

Mitragotri, his research group, and their collaborators from the University of Michigan succeeded in synthesizing the particles by creating a polymer doughnut-shaped template, coating the template with up to nine layers of hemoglobin and other proteins, then removing the core template. The resulting particles have the same size and flexibility, and can carry as much oxygen, as natural red blood cells. The flexibility, absent in “conventional” polymer-based biomaterials developed as carriers for therapeutic and diagnostic agents, gives the sRBCsthe ability to flow through channels smaller than their resting diameter, stretching in response to flow and regaining their discoidal shape upon exiting the capillary, just as their natural counterparts do.

In addition to synthesizing particles that mimic the shape and properties of healthy RBCs, the technique described in the paper can also be used to develop particles that mimic the shape and properties of diseased cells, such as those found in sickle-cell anemia and hereditary eliptocytosis. The availability of such synthetic diseased cells is expected to lead to greater understanding of how those diseases and others affect RBCs.

The discovery is described in the current online edition of Proceedings of the National Academy of Science, and will be published in the print version of the journal in the near future. UCSB graduate student Nishti Doshi was the lead author of the paper; former post-doctoral researcher Alisar Zahr (now at Harvard Medical School’s Schepers Eye Research Institute), Mitragotri, and their University of Michigan collaborators Srijanani Bhaskar and professor Joerg Lahann were co-authors.

Links:
Paper on line at PNAS: www.pnas.org/cgi/doi/10.1073/pnas.0907127106
Mitragotri Research Group: drugdelivery.engr.ucsb.edu
Mitrtagotri Faculty Page at UCSB: www.chemengr.ucsb.edu/people/faculty_d.php?id=19
Lahann Research Group at University of Michigan: www.engin.umich.edu/research/lahann

Image links:
http://engineering.ucsb.edu/images/news/synthetic_rbc.jpg
http://engineering.ucsb.edu/images/news/synthetic_rbc_bw.jpg

About the College of Engineering at UC Santa Barbara
The College of Engineering at UC Santa Barbara is a global leader in bioengineering, chemical and computational engineering, materials science, nanotechnology and physics. UCSB boasts five Nobel Laureates (four in sciences and engineering) and one winner of the prestigious international Millennium Technology Prize. Our students, professors and staff thrive in a uniquely-successful interdisciplinary and entrepreneurial culture. Our professors’ research is among the most cited by their peers, evidence of the significance and relevance of their work.   

Contact: Tony Rairden
Phone: (805) 893-4301
Cell Phone: (805) 453-0123
eMail: TRairden(at)Engineering(dot)UCSB(dot)edu

# # #

Read the full story at http://www.prweb.com/releases/2009/12/prweb3341934.htm.


'/>"/>
Source: PRWeb
Copyright©2009 Vocus, Inc.
All rights reserved  

Related medicine news :

1. Using synthetic evolution to study the brain: Researchers model key part of neurons
2. Recent Article Reveals Medical Ghostwriting Suppressed Links Between Synthetic Hormones and Breast Cancer
3. Synthetic Protein Thwarts HIV Infection in Lab
4. Thomson Reuters Launches New Developments to Support Synthetic Chemists
5. Sigma-Aldrich Offers Customizable Synthetic Extracellular Matrix for Stem Cell Research
6. Synthetic biology -- opportunities and risks
7. New Study Finds Yet Another Link to Cancer, Synthetic Hormones
8. CPC Files Patent for Synthetic Sealant for the MedClose(TM) Vascular Closure System (VCS)
9. Quark Pharmaceuticals Presents Data on Synthetic siRNAs for Prevention of Ocular and Inner Ear Sensory Cell Damage
10. Organic Left Standing as the Gold Standard for Consumers Looking to Avoid Food Produced With Synthetic Growth Hormones
11. QLT announces completion of Phase Ia safety trial of its synthetic retinoid product
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Synthetic Red Blood Cells Developed 
(Date:10/13/2017)... ... , ... The American Board of Family Medicine's (ABFM) Board of Directors has ... succeeding Dr. James C. Puffer upon his retirement. Dr. Newton will serve in the ... at the end of 2018. Upon assuming the role of President and CEO on ...
(Date:10/13/2017)... ... October 13, 2017 , ... Apple Rehab Shelton Lakes , which ... evacuation of the facility as part of a disaster drill on October 3rd. , ... and Shelton City Emergency Manager, as well as the Connecticut Long Term Care ...
(Date:10/13/2017)... ... October 13, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The ... the most popular and least understood books in the Holy Scriptures, Revelation. The Book ... have baffled scholars for centuries. Many have tossed it off as mere rubbish, but ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... for healthcare compliance program management, will showcase a range of technology and learning ... Assisted Living (NCAL) Convention and Expo to be held October 14–18, 2017 at ...
(Date:10/12/2017)... ... 12, 2017 , ... The American College of Medical Informatics (ACMI) will present ... the Opening Session of AMIA’s Annual Symposium in Washington, D.C. AMIA’s Annual Symposium ... Collen, a pioneer in the field of medical informatics, this prestigious award is presented ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)... DIEGO , Oct. 12, 2017 AVACEN ... recognized the company with their  2017 New Product Innovation Award ... based on extensive primary and secondary medical device market research ... Medical, through its first-to-market OTC, drug-free pain relief product, the ... unique approach to treating fibromyalgia widespread pain. ...
(Date:10/11/2017)... 11, 2017  BioPharmX Corporation (NYSE MKT: BPMX) researchers ... an innovative way to use nonlinear optical imaging to ... new drugs. ... will show how researchers from BioPharmX and the Wellman ... used a suite of imaging techniques in what is ...
(Date:10/11/2017)...  Hill-Rom Holdings, Inc. ("Hill-Rom") (NYSE: HRC), today provided ... Piedras, Puerto Rico , where the ... Following a comprehensive onsite ... structural damage, temporary loss of power and minimal water ... manufacturing operations have resumed, and the company expects to ...
Breaking Medicine Technology: