Navigation Links
Synthetic HDL Could Fight Heart Disease
Date:1/30/2009

Sponge-like molecule sops up bad lipoproteins, researchers say

FRIDAY, Jan. 30 (HealthDay News) -- A synthetic high-density lipoprotein (HDL) -- the "good" cholesterol -- may hold promise for combating chronically high cholesterol levels and the deadly cardiovascular disease it can cause.

The synthetic HDL, created by Northwestern University researchers, is close in size to natural HDL with a near-matching general surface composition. It also has the ability to bind irreversibly to cholesterol.

"We have designed and built a cholesterol sponge. The synthetic HDL features the basics of what a great cholesterol drug should be," study co-leader Chad A. Mirkin, a Northwestern professor of medicine and also materials science and engineering, said in a news release issued by the school.

The findings were published online in the Journal of the American Chemical Society.

With a gold nanoparticle as its core, synthetic HDL has two lipid layers covered by the main component of natural HDL -- the APOA1 protein.

"Cholesterol is essential to our cells, but chronic excess can lead to dangerous plaque formation in our arteries," study co-leader Dr. Shad Thaxton, an assistant professor of urology in Northwestern's Feinberg School of Medicine, said in the same news release. "HDL transports cholesterol to the liver, which protects against atherosclerosis. Our hope is that, with further development, our synthetic form of HDL could be used to increase HDL levels and promote better health."

The team will now study and evaluate how synthetic HDL acts in biological conditions.

"Drugs that lower the bad cholesterol, LDL, are available, and you can lower LDL through your diet, but it is difficult to raise the good cholesterol, HDL. We are hopeful that our synthetic HDL will one day help fill this gap in useful therapeutics," Mirkin said.

More information

The Americ
'/>"/>

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Page: 1 2

Related medicine news :

1. Duramed Launches New Indication for ENJUVIA(TM) (Synthetic Conjugated Estrogens, B) at North American Menopause Society Annual Meeting
2. Varian, Inc. Offers New Products for the Rapid Purification of Synthetic Oligonucleotides.
3. Collagen Matrix, Inc. Receives FDA 510(k) Clearance for SynOss(TM) Synthetic Mineral Bone Graft Material
4. New understanding of how big molecules bind will lead to better drugs, synthetic organic materials
5. Synthetic peptoids hold forth promise for new antibiotics
6. Oregon study raises questions on synthetic progestins
7. Experts Agree There is No Scientific Evidence of Health Risks in New Jersey Synthetic Turf Fields
8. Its Safe to Play on Desso Synthetic Turf
9. Synthetic molecules hold promise for new family of anti-cancer drugs
10. Safety of Synthetic Turf Validated by NJ Test Results
11. Pioneering Solutions To Fight Staph, MRSA Infections in Sports Facilities and Synthetic Turf Fields
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Synthetic HDL Could Fight Heart Disease 
(Date:4/17/2015)... San Jose, CA (PRWEB) April 17, 2015 ... of life insurance protection without modifications can now use ... are now general life insurance policy rates that are ... . , The standard plans that are offered are ... for adults aged 18 to 79. There are now ...
(Date:4/17/2015)... (PRWEB) April 17, 2015 Enthusiasts of gourmet ... Rapids, Saturday, April 25, 2015. The event will be held ... & Food (201 Monroe Ave NW, Grand Rapids, MI 49503) ... the West Michigan area. Patrons are encouraged to savor the ... and fun. , This year’s event will feature seven chefs, ...
(Date:4/17/2015)... April 17, 2015 At the end ... Lounge and the “Salute to the Oscars” in the ... Hilton Hotel, overlooking the impressive Los Angeles skyline. These ... by Debbie Durkin, LA’s leading producer of sustainable product ... of the world’s premier providers of eco-friendly and socially ...
(Date:4/17/2015)... New York, New York (PRWEB) April 17, 2015 ... ) that allege this class of prescription ... suffer a heart attack, stroke or other life-threatening ... litigation underway in U.S. District Court, Northern District ... issued by the U.S. Judicial Panel on Multidistrict ...
(Date:4/17/2015)... Organic Valley, the nation’s largest cooperative ... International Year of Soils by “Cycling for Sustainability” through ... employees will travel 215 miles from Auburn, California, to ... about the impact of agriculture on water and soil ... Maine, Wisconsin, Oregon, and Washington state, the cyclists have ...
Breaking Medicine News(10 mins):Health News:General Life Insurance Policy Rates Added to Quotation System at Insurance Website Online 2Health News:Children’s Leukemia Foundation of Michigan Presents 3rd Annual CRUSH Grand Rapids 2Health News:Choices Recovery Speaks with Dakota Hood of “The Hunger Games” about Addiction in Hollywood 2Health News:Testosterone Treatment Lawsuits Increase, as New Report Indicates Over 200 Federal Cases Filed Since March 2Health News:Testosterone Treatment Lawsuits Increase, as New Report Indicates Over 200 Federal Cases Filed Since March 3Health News:Testosterone Treatment Lawsuits Increase, as New Report Indicates Over 200 Federal Cases Filed Since March 4Health News:Organic Valley Farmers and Employees "Cycling for Sustainability" Through 215 Miles of California Watershed April 19-25 2Health News:Organic Valley Farmers and Employees "Cycling for Sustainability" Through 215 Miles of California Watershed April 19-25 3
... Amanda Gardner HealthDay Reporter , THURSDAY, May 26 ... in people whose pain is triggered by certain visual patterns, ... who have migraines accompanied by visual "aura," such as flashes ... a study appearing in the May 26 issue of the ...
... prevent organ transplantation rejection, inhibits breast cancer growth in ... in the May 26th PLoS ONE. Nancy Klauber-DeMore, ... have a rationale for performing human clinical trials to ... Since Tacrolimus is already an FDA-approved drug, the safety ...
... in the swine flu virus over the past three decades can ... pigs, a new study reports. The finding stems from an ... were transported from one region to another, the genetic material of ... the diversity of the virus, according to the study, done by ...
... residents of the Stroke Belta southern portion of the ... greater incidence of cognitive decline than other regions of ... of this population are to blame. Results of this ... and Stroke (NINDS), are published in Annals of ...
... Gordon HealthDay Reporter , WEDNESDAY, May 25 (HealthDay ... percent between 1998 and 2007, new government research shows. ... powerful germs -- Neisseria meningitidis and Streptococcus ... fewer infections among young children, the burden of the disease ...
... Precision tinted lenses have been used widely to ... increasingly used for migraine sufferers, but until now the ... published in the journal Cephalalgia , published by ... first time to suggest a neurological basis for these ...
Cached Medicine News:Health News:Special Tinted Glasses May Stymie Migraines 2Health News:Common transplant drug inhibits breast cancer growth, UNC laboratory study shows 2Health News:Tracking Swine Flu Virus in Pigs Reveals Mutations 2Health News:Cognitive decline incidence higher in Southern stroke belt 2Health News:CDC Report Shows Bacterial Meningitis Cases on the Decline 2Health News:CDC Report Shows Bacterial Meningitis Cases on the Decline 3Health News:CDC Report Shows Bacterial Meningitis Cases on the Decline 4Health News:Tinted specs offer real migraine relief, says fMRI study 2Health News:Tinted specs offer real migraine relief, says fMRI study 3
(Date:4/17/2015)... 2015 Research and Markets ( ... "Medical Device Outsourcing - Global Strategic Business ... This report analyzes the worldwide markets for Medical ... Device Categories: Class I, Class II, and Class ... report Include - Radiology, Orthopedic, Neurology, Cardiology, and ...
(Date:4/17/2015)... 17, 2015  Trovagene, Inc., (NASDAQ:  TROV) a ... clinical data presented at the 2015 European Lung ... Cancer Monitoring ℠ (PCM) platform outperformed tissue ... EGFR T790M mutations in metastatic lung cancer ... T790M Mutation in Urinary Circulating Tumor DNA from ...
(Date:4/17/2015)... Steven Rash , the CEO of Algae ... subsidiary American Seed & Oil Company, presented the Company,s ... in New York City.  Mr. Rash,s presentation featured the ... & Oil Company has recently announced the Dube ... Foods , the EpiVape , and Hempster ...
Breaking Medicine Technology:Medical Device Outsourcing (Radiology, Orthopedic, Neurology, Cardiology, and Others) Market 2015 - Global Strategic Business Report 2Medical Device Outsourcing (Radiology, Orthopedic, Neurology, Cardiology, and Others) Market 2015 - Global Strategic Business Report 3Trovagene's Urinary ctDNA Assay Outperforms Tissue Biopsy in Clinical Study for the Detection of EGFR T790M Mutations in Metastatic Lung Cancer Patients 2Trovagene's Urinary ctDNA Assay Outperforms Tissue Biopsy in Clinical Study for the Detection of EGFR T790M Mutations in Metastatic Lung Cancer Patients 3Trovagene's Urinary ctDNA Assay Outperforms Tissue Biopsy in Clinical Study for the Detection of EGFR T790M Mutations in Metastatic Lung Cancer Patients 4American Seed & Oil Company Benchmarks its Consumer Product Development Strategy Against Proctor & Gamble 2American Seed & Oil Company Benchmarks its Consumer Product Development Strategy Against Proctor & Gamble 3
... Ultra MD Super Pulse sealed CO2 ... versatility backed by the experience and support ... years of surgical laser experience. All settings ... finger. The Ultra MD Super Pulse surgical ...
The compact size and portability of the Epic system makes it a cost-effective solution for single or multi-office use....
A soft contact lens that lets presbyopes see clearly and comfortably at all distances , without the hassles of bifocals or reading glasses. Recommended for daily wear. Also approved for extended wear...
... display of corneal layers: endothelium, ... epithelial layers. Accurate analysis of ... keratocytes, nerve fibres, basal & ... surgery and pathology: optical pachymetry, ...
Medicine Products: