Navigation Links
Synthetic HDL Could Fight Heart Disease
Date:1/30/2009

Sponge-like molecule sops up bad lipoproteins, researchers say

FRIDAY, Jan. 30 (HealthDay News) -- A synthetic high-density lipoprotein (HDL) -- the "good" cholesterol -- may hold promise for combating chronically high cholesterol levels and the deadly cardiovascular disease it can cause.

The synthetic HDL, created by Northwestern University researchers, is close in size to natural HDL with a near-matching general surface composition. It also has the ability to bind irreversibly to cholesterol.

"We have designed and built a cholesterol sponge. The synthetic HDL features the basics of what a great cholesterol drug should be," study co-leader Chad A. Mirkin, a Northwestern professor of medicine and also materials science and engineering, said in a news release issued by the school.

The findings were published online in the Journal of the American Chemical Society.

With a gold nanoparticle as its core, synthetic HDL has two lipid layers covered by the main component of natural HDL -- the APOA1 protein.

"Cholesterol is essential to our cells, but chronic excess can lead to dangerous plaque formation in our arteries," study co-leader Dr. Shad Thaxton, an assistant professor of urology in Northwestern's Feinberg School of Medicine, said in the same news release. "HDL transports cholesterol to the liver, which protects against atherosclerosis. Our hope is that, with further development, our synthetic form of HDL could be used to increase HDL levels and promote better health."

The team will now study and evaluate how synthetic HDL acts in biological conditions.

"Drugs that lower the bad cholesterol, LDL, are available, and you can lower LDL through your diet, but it is difficult to raise the good cholesterol, HDL. We are hopeful that our synthetic HDL will one day help fill this gap in useful therapeutics," Mirkin said.

More information

The American Heart Association has more about cholesterol.



-- Kevin McKeever



SOURCE: Northwestern University, news release, January 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Duramed Launches New Indication for ENJUVIA(TM) (Synthetic Conjugated Estrogens, B) at North American Menopause Society Annual Meeting
2. Varian, Inc. Offers New Products for the Rapid Purification of Synthetic Oligonucleotides.
3. Collagen Matrix, Inc. Receives FDA 510(k) Clearance for SynOss(TM) Synthetic Mineral Bone Graft Material
4. New understanding of how big molecules bind will lead to better drugs, synthetic organic materials
5. Synthetic peptoids hold forth promise for new antibiotics
6. Oregon study raises questions on synthetic progestins
7. Experts Agree There is No Scientific Evidence of Health Risks in New Jersey Synthetic Turf Fields
8. Its Safe to Play on Desso Synthetic Turf
9. Synthetic molecules hold promise for new family of anti-cancer drugs
10. Safety of Synthetic Turf Validated by NJ Test Results
11. Pioneering Solutions To Fight Staph, MRSA Infections in Sports Facilities and Synthetic Turf Fields
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Synthetic HDL Could Fight Heart Disease 
(Date:6/27/2016)... ... June 27, 2016 , ... "FCPX editors can now reveal their media with ... X," said Christina Austin - CEO of Pixel Film Studios. , ProSlice Color ... users can now reveal the media of their split screens with growing colorful ...
(Date:6/27/2016)... ... June 27, 2016 , ... ... patient payment industry today announced its strategic partnership with Connance, a healthcare ... , The two companies’ proven, proprietary technology combine to provide health systems, ...
(Date:6/27/2016)... Park, KS (PRWEB) , ... June 27, 2016 , ... ... in retailers of Eyeglasses . , Millions of individuals in the United States ... eyeglasses have become a way to both correct vision and make a fashion statement. ...
(Date:6/26/2016)... Battle Creek, Michigan (PRWEB) , ... June 26, 2016 , ... ... abuse, joined as sponsor of the 2016 Cereal Festival and World’s Longest Breakfast Table ... held in honor of the city’s history as home to some of the world’s ...
(Date:6/26/2016)... ... ... PawPaws brand pet supplements owned by Whole Health Supply is ... of felines. The formula is all-natural and is made from Chinese herbs that have ... Kidney Support Supplement Soft Chews are Astragalus Root Extract and Rehmannia Root Extract ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 ... appointment of Dr. Edward Futcher to ... Director, effective June 23, 2016.Dr. Futcher was also ... and Governance Committees.  As a non-executive member of ... expertise and strategic counsel to VolitionRx in connection ...
(Date:6/23/2016)... June 23, 2016 Research and ... Excipients Market by Type (Organic Chemical (Sugar, Petrochemical, Glycerin), ... Topical, Coating, Parenteral) - Global Forecast to 2021" ... The global pharmaceutical excipients market is projected ... CAGR of 6.1% in the forecast period 2016 to ...
(Date:6/23/2016)... 23, 2016 Research and Markets has ... 52" report to their offering. ... creates a favourable commercial environment for MedImmune to enter. The ... that will serve to drive considerable growth for effective anti-influenza ... to cap sales considerably, but development is still in its ...
Breaking Medicine Technology: