Navigation Links
Synthetic HDL Could Fight Heart Disease
Date:1/30/2009

Sponge-like molecule sops up bad lipoproteins, researchers say

FRIDAY, Jan. 30 (HealthDay News) -- A synthetic high-density lipoprotein (HDL) -- the "good" cholesterol -- may hold promise for combating chronically high cholesterol levels and the deadly cardiovascular disease it can cause.

The synthetic HDL, created by Northwestern University researchers, is close in size to natural HDL with a near-matching general surface composition. It also has the ability to bind irreversibly to cholesterol.

"We have designed and built a cholesterol sponge. The synthetic HDL features the basics of what a great cholesterol drug should be," study co-leader Chad A. Mirkin, a Northwestern professor of medicine and also materials science and engineering, said in a news release issued by the school.

The findings were published online in the Journal of the American Chemical Society.

With a gold nanoparticle as its core, synthetic HDL has two lipid layers covered by the main component of natural HDL -- the APOA1 protein.

"Cholesterol is essential to our cells, but chronic excess can lead to dangerous plaque formation in our arteries," study co-leader Dr. Shad Thaxton, an assistant professor of urology in Northwestern's Feinberg School of Medicine, said in the same news release. "HDL transports cholesterol to the liver, which protects against atherosclerosis. Our hope is that, with further development, our synthetic form of HDL could be used to increase HDL levels and promote better health."

The team will now study and evaluate how synthetic HDL acts in biological conditions.

"Drugs that lower the bad cholesterol, LDL, are available, and you can lower LDL through your diet, but it is difficult to raise the good cholesterol, HDL. We are hopeful that our synthetic HDL will one day help fill this gap in useful therapeutics," Mirkin said.

More information

The American Heart Association has more about cholesterol.



-- Kevin McKeever



SOURCE: Northwestern University, news release, January 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Duramed Launches New Indication for ENJUVIA(TM) (Synthetic Conjugated Estrogens, B) at North American Menopause Society Annual Meeting
2. Varian, Inc. Offers New Products for the Rapid Purification of Synthetic Oligonucleotides.
3. Collagen Matrix, Inc. Receives FDA 510(k) Clearance for SynOss(TM) Synthetic Mineral Bone Graft Material
4. New understanding of how big molecules bind will lead to better drugs, synthetic organic materials
5. Synthetic peptoids hold forth promise for new antibiotics
6. Oregon study raises questions on synthetic progestins
7. Experts Agree There is No Scientific Evidence of Health Risks in New Jersey Synthetic Turf Fields
8. Its Safe to Play on Desso Synthetic Turf
9. Synthetic molecules hold promise for new family of anti-cancer drugs
10. Safety of Synthetic Turf Validated by NJ Test Results
11. Pioneering Solutions To Fight Staph, MRSA Infections in Sports Facilities and Synthetic Turf Fields
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Synthetic HDL Could Fight Heart Disease 
(Date:12/8/2016)... (PRWEB) , ... December 08, 2016 , ... ... accreditation with distinction by the Undersea and Hyperbaric Medical Society (UHMS), the leading ... advanced care and patient safety. Only a few hospitals and facilities have earned ...
(Date:12/8/2016)... ... 08, 2016 , ... Mirixa Corporation , a leading ... pharmacist-delivered patient care services, has announced the promotions of Karen Litsinger to senior ... of sales. , Litsinger joined Mirixa in 2008 after serving as a ...
(Date:12/8/2016)... ... December 08, 2016 , ... SunView ... customers and employees that are both engaging and easy to use. Coming off ... the software company revealed today its plans to roll out new AI-powered self-service ...
(Date:12/8/2016)... , ... December 08, 2016 , ... California Senate Bill ... payments per workers’ compensation claim in 2013 and 2014, according to CompScope™ Medical ... Institute (WCRI) . , According to the study, medical payments per claim in California ...
(Date:12/8/2016)... ... December 08, 2016 , ... The Dianne Michael Insurance ... in Hamilton County, is embarking on a charity drive with the aim of ... homes for orphaned or neglected senior dogs in the Cincinnati region, and LuvFurMutts ...
Breaking Medicine News(10 mins):
(Date:12/9/2016)... Dec. 9, 2016  Forge Therapeutics, Inc. today ... Stock Exchange: EVT, TecDAX, ISIN: DE0005664809) to advance ... the treatment of bacterial infections including those caused ... as an attractive antibacterial target for more than ... suitable chemical starting points has hampered its progress. ...
(Date:12/8/2016)... , Dec. 8, 2016 Australia Ophthalmic ... new report, "Australia Ophthalmic Lasers Market Outlook to 2022", ... market. The report provides value, in millions of US ... market segements - Excimer Lasers, Femtosecond Lasers and YAG ... distribution shares data for each of these market segements, ...
(Date:12/8/2016)... Dec. 8, 2016 KEY FINDINGS ... Patient warming ... of blood during surgeries, lowering the risks of neurological disorders ... of SSIs. The patient warming systems can be segmented into ... benefits in turn reduce the stay at hospitals thus, lowering ...
Breaking Medicine Technology: