Navigation Links
Synthetic HDL Could Fight Heart Disease
Date:1/30/2009

Sponge-like molecule sops up bad lipoproteins, researchers say

FRIDAY, Jan. 30 (HealthDay News) -- A synthetic high-density lipoprotein (HDL) -- the "good" cholesterol -- may hold promise for combating chronically high cholesterol levels and the deadly cardiovascular disease it can cause.

The synthetic HDL, created by Northwestern University researchers, is close in size to natural HDL with a near-matching general surface composition. It also has the ability to bind irreversibly to cholesterol.

"We have designed and built a cholesterol sponge. The synthetic HDL features the basics of what a great cholesterol drug should be," study co-leader Chad A. Mirkin, a Northwestern professor of medicine and also materials science and engineering, said in a news release issued by the school.

The findings were published online in the Journal of the American Chemical Society.

With a gold nanoparticle as its core, synthetic HDL has two lipid layers covered by the main component of natural HDL -- the APOA1 protein.

"Cholesterol is essential to our cells, but chronic excess can lead to dangerous plaque formation in our arteries," study co-leader Dr. Shad Thaxton, an assistant professor of urology in Northwestern's Feinberg School of Medicine, said in the same news release. "HDL transports cholesterol to the liver, which protects against atherosclerosis. Our hope is that, with further development, our synthetic form of HDL could be used to increase HDL levels and promote better health."

The team will now study and evaluate how synthetic HDL acts in biological conditions.

"Drugs that lower the bad cholesterol, LDL, are available, and you can lower LDL through your diet, but it is difficult to raise the good cholesterol, HDL. We are hopeful that our synthetic HDL will one day help fill this gap in useful therapeutics," Mirkin said.

More information

The American Heart Association has more about cholesterol.



-- Kevin McKeever



SOURCE: Northwestern University, news release, January 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Duramed Launches New Indication for ENJUVIA(TM) (Synthetic Conjugated Estrogens, B) at North American Menopause Society Annual Meeting
2. Varian, Inc. Offers New Products for the Rapid Purification of Synthetic Oligonucleotides.
3. Collagen Matrix, Inc. Receives FDA 510(k) Clearance for SynOss(TM) Synthetic Mineral Bone Graft Material
4. New understanding of how big molecules bind will lead to better drugs, synthetic organic materials
5. Synthetic peptoids hold forth promise for new antibiotics
6. Oregon study raises questions on synthetic progestins
7. Experts Agree There is No Scientific Evidence of Health Risks in New Jersey Synthetic Turf Fields
8. Its Safe to Play on Desso Synthetic Turf
9. Synthetic molecules hold promise for new family of anti-cancer drugs
10. Safety of Synthetic Turf Validated by NJ Test Results
11. Pioneering Solutions To Fight Staph, MRSA Infections in Sports Facilities and Synthetic Turf Fields
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Synthetic HDL Could Fight Heart Disease 
(Date:10/13/2017)... ... ... While it’s often important to take certain medications during the night, finding ... identified a solution. , She developed a prototype for MOTION LIGHT-UP PILL BOX to ... the need to turn on a light when taking medication during the night, allowing ...
(Date:10/13/2017)... ... 2017 , ... PurhealthRX , a leading Health and Nutrition Company, is ... to full spectrum CBD oil will revolutionize the rapidly growing CBD market by reducing ... easily incorporated into liquid products, while reducing costs to end users. , The team ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Apple ... care services, staged a mock evacuation of the facility as part of a disaster ... Fire Department, Echo Hose EMS and Shelton City Emergency Manager, as well as the ...
(Date:10/13/2017)... ... October 13, 2017 , ... Ellevate Network, the leading ... to advocate for action towards gender equality at their inaugural Summit in New York ... globe, and reached a social audience of over 3 million. To watch the Mobilize ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... giving viewers the lowdown on sciatica in a new episode of "Success Files," ... on current events and innovation and investigates each subject in-depth with passion and ...
Breaking Medicine News(10 mins):
(Date:9/25/2017)... PROVIDENCE, R.I. , Sept. 25, 2017 /PRNewswire/ ... immunogenicity assessment, vaccine design, and immune-engineering today announced ... focused on the development of personalized therapeutic cancer ... and has provided exclusive access to enabling technologies ... MSc Eng., MBA will lead EpiVax Oncology as ...
(Date:9/19/2017)... LOUISVILLE, Ky. , Sept. 19, 2017   ZirMed ... and predictive analytics, today announced that it has been ranked ... the Black Book™ Rankings 2017 User Survey. ZirMed ... software solution for large hospitals and medical centers over 200 ... in Black Book,s healthcare technology user survey history. ...
(Date:9/12/2017)... -- Consumer reviews on the independent review site Consumer Affairs ... for hearing aids, ranking it higher than Miracle Ear ™, ... ... Hearing Aids ... store that provides high performance, state-of-the-art, German-engineered hearing aids directly to ...
Breaking Medicine Technology: