Navigation Links
Synthetic HDL: A new weapon to fight cholesterol problems
Date:1/9/2009

EVANSTON, Ill. --- Buttery Christmas cookies, eggnog, juicy beef roast, rich gravy and creamy New York-style cheesecake. Happy holiday food unfortunately can send blood cholesterol levels sky high.

Northwestern University scientists now offer a promising new weapon -- synthetic high-density lipoprotein (HDL), the "good" cholesterol -- that could help fight chronically high cholesterol levels and the deadly heart disease that often results.

The researchers successfully designed synthetic HDL and show that their nanoparticle version is capable of irreversibly binding cholesterol. The synthetic HDL, based on gold nanoparticles, is similar in size to HDL and mimics HDL's general surface composition.

The study is published online by the Journal of the American Chemical Society (JACS).

"We have designed and built a cholesterol sponge. The synthetic HDL features the basics of what a great cholesterol drug should be," said Chad A. Mirkin, George B. Rathmann Professor of Chemistry in the Weinberg College of Arts and Sciences, professor of medicine and professor of materials science and engineering. Mirkin and Shad Thaxton, M.D., assistant professor of urology in Northwestern's Feinberg School of Medicine, led the study.

"Drugs that lower the bad cholesterol, LDL, are available, and you can lower LDL through your diet, but it is difficult to raise the good cholesterol, HDL," said Mirkin. "I've taken niacin to try and raise my HDL, but the side effects are bad so I stopped. We are hopeful that our synthetic HDL will one day help fill this gap in useful therapeutics."

In creating synthetic HDL the researchers started with a gold nanoparticle as the core. They then layered on a lipid that attaches to the gold surface, then another lipid and last a protein, called APOA1, the main protein component of naturally occurring HDL. The final high-density lipoprotein nanoparticles are each about 18 nanometers in dia
'/>"/>

Contact: Marla Paul
marla-Paul@northwestern.edu
312-503-8928
Northwestern University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New center launched today to spearhead UK research in synthetic biology
2. Researcher refining synthetic molecules to prevent HIV resistance
3. FDA Approves Durameds Synthetic Conjugated Estrogens-A Vaginal Cream
4. Caltech engineers build first-ever multi-input plug-and-play synthetic RNA device
5. Novel Solid-State Laser Design Based on Synthetic Diamond From Element Six Opens up New Applications
6. Pioneering Solutions To Fight Staph, MRSA Infections in Sports Facilities and Synthetic Turf Fields
7. Safety of Synthetic Turf Validated by NJ Test Results
8. Synthetic molecules hold promise for new family of anti-cancer drugs
9. Its Safe to Play on Desso Synthetic Turf
10. Experts Agree There is No Scientific Evidence of Health Risks in New Jersey Synthetic Turf Fields
11. Oregon study raises questions on synthetic progestins
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/1/2015)... “ The Barrel Mill ” was featured on NewsWatch ... look at the latest and coolest technology products and services ... a technology expert, conducted the review and shared with viewers ... According to Home Distillation of Alcohol, it's understood that oak ... pretty cool product that’ll help anyone achieve a barrel aged ...
(Date:3/1/2015)... February 28, 2015 CrossFit Attollo is a ... are offering a special discount to new members. Now ... for a three month contract will receive their fourth month ... would cost members $440. The three month contract is ... and then the fourth month comes in at only $55. ...
(Date:2/28/2015)... In recent years Medical Marijuana has continuously ... as a way for them to expand their patient base ... medicine. Since the FDA still lists Cannabis as a Schedule ... licensed physicians that can help guide them when recommending ... in Santa Cruz, CA is a leader in the ...
(Date:2/28/2015)... February 28, 2015 In a recent ... of Game Change Athlete Development Services ... about the benefits of athlete development and player engagement ... the unique challenges that athletes face and how off-field ... success. , Fletcher became involved in athlete development issues ...
(Date:2/28/2015)... 2015 With their commitment to achieving ... an additional exercise to their already robust library of ... most commonly known as, is often performed on a ... executed in a relatively safe manner and can be ... The full description of “Rope Pulls” is located in ...
Breaking Medicine News(10 mins):Health News:An Oak Infusion Spiral was Featured on NewsWatch Television on January 30, 2015 2Health News:CrossFit Gym in Vancouver WA Offers Spring Special 2Health News:Reputable Cannabis Doctor In Santa Cruz and Monterey Joins the Medical Cannabis Network 2Health News:SCI TV Covers Athlete Development with Duncan Fletcher 2Health News:SCI TV Covers Athlete Development with Duncan Fletcher 3
... law suit filed against sunscreen manufacturers in California as they ... on the other hand still recommend the liberal use of ... (SPF) ratings nor the label on the products gives a ... not cause burning but do cause aging of the skin ...
... of marriages. // ,Pathology labs in the city have registered ... season. ,Rajesh Bose (name changed) got an HIV test ... But her parents thought I was a flirt," said Bose. "But when ... ,Not only men but prospective brides too are going in ...
... Roseborough et al., mitochondrial K-ATP channel opener, diazoxide, prevents ... are the common problems that occur during aortic surgery ... in neurological deficits. But the works of Roseborough et ... injuries. , The results of his work ...
... protein present in chronic inflammatory conditions called heat shock ... – which is associated with the immune responses, a ... ,The specific response has earlier been observed in juvenile ... the role of HSP60 in inflammatory myositis. Inflammatory myositis ...
... club, for people living with HIV/Aids, started by Luta Shaba, an ... country. // ,Shaba says she dreams of ... use recommended safe sex methods. She says many of her ... large social stigma attached to HIV/Aids. Her club is a huge ...
... a coordinated action plan to check the deteriorating sexual ... ,The plan by UN agencies, WHO and UN Population ... more than half a million women die during pregnancy ... annually. , ,"There is a really worrying rise ...
Cached Medicine News:Health News:New Way To Combat Spinal Cord Injury during Aortic Surgery 2Health News:Proteins – A New Way to Treat Children's Muscle Diseas 2
(Date:3/1/2015)... , March 1, 2015  Patients suffering from ... against this debilitating foot ailment, according to research ... ,s Annual Scientific Meeting . Researchers utilized ... emulsify and remove diseased fasciitis tissue. Permanently removing ... to regrow in its place, restoring normal function. ...
(Date:2/27/2015)... WuXi PharmaTech (Cayman) Inc. (NYSE:  WX), a ... the pharmaceutical, biotechnology, and medical device industries with operations ... the United States , congratulates our partner TaiMed ... FDA for ibalizumab (TMB355). The FDA designates a drug ... or in combination with one or more other drugs, ...
(Date:2/27/2015)... Israele, February 27, 2015 ... sviluppo dell,innovativo sistema di monitoraggio dell,infarto congestizio (CHF ... sull,uomo-     ... di nuovo sistema per il monitoraggio cardiaco destinato ... annunciato oggi di aver concluso una raccolta di ...
Breaking Medicine Technology:Interventional radiology treatment relieves chronic plantar fasciitis 2Interventional radiology treatment relieves chronic plantar fasciitis 3WuXi Congratulates TaiMed Biologics on Receiving Breakthrough Therapy Designation from U.S. FDA 2Vectorious Medical Technologies completa una raccolta di 5 milioni di dollari 2
... IRVINE, Calif., Sept. 28 Cobalis Corp. (Pink ... Update Conference Call to provide investors and shareholders with further ... securities, financial and legal issues. Shareholders and investors ... held Tuesday, October 5, 2010 at 1:15pm Pacific Time. Interested ...
... Sept. 28 Grammy Award winner Gloria Gaynor -- whose ... -- will appear at AARP,s Orlando@50+ National Event & ... her own experience with this potentially debilitating condition. This high ... place September 30-October 2 at the Orange County ...
Cached Medicine Technology:Cobalis Corp. Announces Second Update Conference Call for Investors on October 5, 2010 2Gloria Gaynor to Appear at AARP's Orlando@50+ National Event & Expo 2
... best lens available for ... One 62 mirror. Tilted ... and laser beam astigmatism. ... used on most patients ...
Mcintyre straight lachrymal cannula, closed end, two side ports at 0.3 mm, straight shaft....
Lachrymal cannula, straight....
The first easy-to use peroxide system offers proven efficacy that's pure and simple. The convenience of a multi-purpose cleaner/rinse in one bottle. Added power of peroxide in the other bottle....
Medicine Products: