Navigation Links
Symptoms have little value for early detection of ovarian cancer
Date:1/28/2010

Use of symptoms to trigger a medical evaluation for ovarian cancer does not appear to detect early-stage ovarian cancer earlier and would likely result in diagnosis in only 1 out of 100 women in the general population with such symptoms, according to an article published online January 28 in the Journal of the National Cancer Institute.

Researchers at Fred Hutchinson Cancer Research Center in Seattle assessed the predictive value of certain symptoms, including abdominal pain or bloating and urinary frequency, which were cited in a recent consensus statement as a way to diagnose ovarian cancer earlier.

Mary Anne Rossing, Ph.D., of the Program in Epidemiology at Fred Hutchinson, and colleagues conducted in-person interviews with 812 patients aged 35-74 years who had epithelial ovarian cancer that was diagnosed from 2002 through 2005. They compared the results from these case patients with results from interviews with 1,313 population-based control subjectswomen who did not have ovarian cancer. The researchers assessed the sensitivity, specificity, and positive predictive value of a proposed symptom index and of symptoms included in the consensus recommendation.

Symptoms appeared in most case patients only about 5 or fewer months before diagnosis. Women with early-stage ovarian cancer were somewhat less likely to have symptoms (except nausea) than those with late-stage cancer. The estimated positive predictive value of the symptoms was 0.6%𔂿.1% overall and less than 0.5% for early-stage disease.

The authors conclude that 100 symptomatic women would need to be evaluated to detect one woman with ovarian cancer.

"The low positive predictive value of symptoms to detect ovarian cancerparticularly at an early stageargues for a cautious approach to the use of symptom patterns to trigger extensive medical evaluation for ovarian cancer," the authors write.

In an accompanying editorial, Beth Y. Karlan, M.D., and Ilana Cass, M.D., of the Division of Gynecologic Oncology at Cedars-Sinai Medical Center in Los Angeles, note the strengths of the study, including in-person interviews and large number of patients, but also point out its limitations: inherent recall bias and survival bias in case patients and control subjects. Recall bias is always a possibility in casecontrol studies in that case subjects may be more likely to remember symptoms than control subjects.

"Importantly, these findings remind us that wide recognition of symptoms alone will not incrementally improve the overall survival from ovarian cancer," the editorialists write. "Rather, they highlight the urgent need to develop better molecular markers and improved imaging modalities for ovarian cancer screening."


'/>"/>

Contact: Steve Graff
jncimedia@oxfordjournals.org
301-841-1285
Journal of the National Cancer Institute
Source:Eurekalert

Related medicine news :

1. New treatment effective in counteracting cocaine-induced symptoms
2. Study suggests loss of 2 types of neurons -- not just 1 -- triggers Parkinsons symptoms
3. Effectiveness of mouse breeds that mimic Alzheimers disease symptoms questioned
4. New study: Pine bark reduces perimenopausal symptoms
5. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
6. Clean to Ease Allergy and Asthma Symptoms
7. Antidepressant shows early promise in treating agitation and psychotic symptoms of dementia
8. New study: Pine bark extract reduces ADHD symptoms in children
9. Study finds post-traumatic stress symptoms in adolescent children of cancer patients
10. Study shows autism symptoms can improve into adulthood
11. Common Early-Warning Symptoms of Ovarian Cancer Identified in CDC/Thomson Healthcare Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/27/2016)... ... ... With a team of certified experts, Validation Center is ... GMP accreditation, Validation Center is also a registered authority of the international system ... Validation Center is ISO17025 accredited and only offers its clients the latest technology, ...
(Date:5/26/2016)... ... 2016 , ... W.S. Badger Co. Inc ., the maker of certified ... Work Works Award for its use of effective workplace strategies to increase business and ... administered by the Families and Work Institute (FWI) and the Society for Human Resource ...
(Date:5/26/2016)... Atlanta, Georgia (PRWEB) , ... May 26, 2016 ... ... a certificate in intellectual property (IP) to its specialty academic programs. , Answering ... joins the college’s existing certificate programs in health law, and environmental and land ...
(Date:5/26/2016)... ... 2016 , ... The Woodlands at John Knox Village , Florida’s first ... for living and healing, celebrated its grand opening, today. The Woodlands at John Knox ... by Empowered Staff. , “This is an incredibly fulfilling time for John Knox Village ...
(Date:5/26/2016)... ... May 26, 2016 , ... MadgeTech will be showcasing its ... manufactured in Warner, New Hampshire at the MadgeTech headquarters. With products sold in more ... trusted by government agencies, including NASA. , In 2012, NASA strategically set up ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... , May 25, 2016 ... & Expo earlier this month, the numbers and momentum ... continue to climb into the billions, more research and ... released 4th Edition State of Legal Marijuana Markets Report ... cannabis-focused data-analysis firm, much of the increase in sector ...
(Date:5/25/2016)... ReportsnReports.com adds "Chronic Cough ... provides an overview on therapeutic pipeline of Chronic ... therapeutics assessment by drug target, mechanism of action ... along with latest updates, and featured news and ... in the therapeutic development for Chronic Cough and ...
(Date:5/24/2016)... HENDERSON, Nev. , May 24, 2016  Diana ... painfully "eats" her organs from the inside out.  This ... her completely dependent on her children and grandchildren to ... of her wheelchair, Diana,s family cannot haul the wheelchair.  ... rides in the car, and Diana is left to ...
Breaking Medicine Technology: