Navigation Links
Switching immunosuppressants reduces cancer risk in kidney
Date:10/31/2009

Switching to a newer type of immunosuppressant drug may reduce the high rate of skin cancer after kidney transplantation, according to research being presented at the American Society of Nephrology's 42nd Annual Meeting and Scientific Exposition in San Diego, CA.

"In spite of the life-saving nature of organ transplantation, the need for transplant recipients to continue treatment with drugs that suppress the immune system to prevent rejection of the organ is associated with a number of side effects, one of which is the development of cancer," said lead researcher Graeme Russ, MD (The Queen Elizabeth Hospital, Australia). "So the search for an immunosuppressive drug which prevents rejection effectively but is associated with lower rates of cancer will be of significant advantage to transplant recipients."

The study included 86 kidney transplant patients who previously had skin cancer (other than melanoma)placing them at particularly high risk of new skin cancers. In Australia, skin cancer is the most common type of cancer occurring post-transplant.

One group of patients remained on standard immunosuppressant drug treatment. The other group was switched to treatment with sirolimusone of a newer class of immunosuppressants called mTOR inhibitors. "Previous studies have suggested that mTOR inhibitors are associated with less cancer than other commonly used agents," according to Russ.

Patients switched to sirolimus had a significantly lower rate of new skin cancers. Overall, new skin cancers developed in 56 percent of patients in the sirolimus group, compared to 81 percent of those who remained on the standard immunosuppressant. Most of the difference reflected a lower rate of one type of cancer, called squamous cell carcinoma.

Nearly half of patients stopped taking sirolimus because of side effects. "In spite of this large dropout rate there was a significantly lower rate of skin cancer development in the sirolimus gro
'/>"/>

Contact: Shari Leventhal
sleventhal@asn-online.org
202-558-8423
American Society of Nephrology
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Switching early breast cancer patients to exemestane improves long-term survival
2. AUDIO from Medialink and Forest Laboratories: Dangers of Switching Medications
3. For Treatment of Dyslipidemia, Surveyed Physicians are Increasingly Switching Patients to a More Potent Statin Following the ENHANCE and SEAS Trials
4. National Pharmacy Omnicare Pays 'Unusual' Settlement to Resolve Charges of Generic Drug Switching in Delaware Nursing Homes, Resulting From 'Qui Tam' Lawsuit
5. Senator Specter: Switching Parties or Coming Home?
6. Patients Urged to be Aware of Prescription Switching
7. Medicare Advantage Open Enrollment Offers One-Time Chance to Change Your Mind: Allsup Outlines Rules for Switching Plans
8. Walgreens Pays $35 Million, Settles Pharmacist-Whistleblower Qui Tam Drug Switching Allegations
9. Attorney General Corbett Announces $36.7 Million Multi-State Settlement With CVS/Caremark in National Dosage-Switching Investigation
10. CVS, Americas Largest Pharmacy Chain, Pays Nearly $37 Million to Settle Federal and State Generic Drug Switching Charges
11. Switching to MA Coverage Unlikely for Current Beneficiaries With MediGap or Medicare Only
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Switching immunosuppressants reduces cancer risk in kidney
(Date:7/31/2015)... (PRWEB) , ... July 31, 2015 , ... ... proud to announce that their latest designer handbag line will be named for ... an Internet sensation as the first globally recognized model with Down syndrome, gracing ...
(Date:7/31/2015)... (PRWEB) , ... July 31, 2015 , ... ... has announced plans to release a newly redesigned website at Healthpointe.net. The new ... enhanced user experience. , The redesign serves to provide smoother interactions between ...
(Date:7/31/2015)... ... July 31, 2015 , ... ZH Healthcare announces a ... , What is HITaaS? Health IT as a Service (HITaaS) is a Healthcare dedicated ... a service (SaaS). , HITaaS manages all aspects of infrastructure, security, ...
(Date:7/31/2015)... ... July 31, 2015 , ... EB ... and Hospital Medicine Practice, is pleased to announce that it has partnered with ... format available on iPhones, iPads, and Android smartphones and tablets. , “The ...
(Date:7/31/2015)... ... ... The Radiology Business Management Association’s 2015 Fall Educational Conference ... Care: A View From Capitol Hill” on Sunday, Sept. 27, 2015, in Austin, Tex. ... has a special understanding of the real world impact of health care policy issues,” ...
Breaking Medicine News(10 mins):Health News:everMaya to Launch Madeline Stuart Handbag Line 2Health News:everMaya to Launch Madeline Stuart Handbag Line 3Health News:Healthpointe Announces Newly Redesigned Website 2Health News:ZH Healthcare Unveils Health IT as a Service (HITaaS) at OSEHRA 2015 2Health News:ZH Healthcare Unveils Health IT as a Service (HITaaS) at OSEHRA 2015 3Health News:ZH Healthcare Unveils Health IT as a Service (HITaaS) at OSEHRA 2015 4Health News:EB Medicine Launches Mobile Application for Pediatric Emergency Medicine 2Health News:EB Medicine Launches Mobile Application for Pediatric Emergency Medicine 3Health News:Congressional Health Caucus Founder Rep. Michael Burgess, MD, to Speak at RBMA Fall Educational Conference 2Health News:Congressional Health Caucus Founder Rep. Michael Burgess, MD, to Speak at RBMA Fall Educational Conference 3
... new vaccine called the TAT vaccine has been developed in ... date. And more importantly it has had a 71% success ... for human testing and this may be the brightest hope ... of the Department of Virology at Italy’s National Health Institute ...
... social neglect and being unwanted even by near and dear ... like the other people - wherever they want and whenever ... passengers. Others are just indifferent. Leaving the ethical issues aside, ... of, many reasons. Primarily the physicians of these patients do ...
... The outgoing U.S. president Bill Clinton will be remembered as ... by becoming the first American president in history to be ... to win at the senate did he save himself and ... of many burning controversies throughout his term and his mid ...
... pregnancy can lead to increased risk of heart problems ... environment contribute to several aspects of cardiovascular risks in ... ,People whose mothers starved during the first 13 ... their adult life, Starvation during mid or late pregnancy ...
... cancer is pancreatic cancer, though it isn’t very common. Globally ... is some hope for the unfortunate victims. A new vaccine ... it has increased the survival rates in many. ,Vaccines ... In cancer, however, they are used along with other therapies ...
... new research into how our immunity works says stress reduces ... long we have agreed that stress is bad for our ... is sure to cause a lot of concern. , ... claming many victims every day, the new buzzword is immunity ...
Cached Medicine News:
(Date:7/30/2015)... VANCOUVER , July 30, 2015  OncoGenex Pharmaceuticals, ... will report its second quarter 2015 financial results on ... conference call and live webcast at 4:30 p.m. Eastern ... development programs and a general corporate update. ... Investor Relations page of the OncoGenex website at ...
(Date:7/30/2015)... 30, 2015  Cleveland Clinic President Wael Barsoum ... last month that industry is compelled to adopt declining ... the efficiencies—and develop the transformational innovations -- required to ... were preceded by Doug Kohrs , past President ... who stressed that industry must add "episode of care," ...
(Date:7/30/2015)...  Medimetriks Pharmaceuticals, Inc. announced today that its ... study for Ozenoxacin, a novel bactericidal non-fluorinated quinolone ... U.S. rights to Ozenoxacin 1% cream.  ... with an emphasis on U.S. patients, involved 412 ... older with a clinical diagnosis of bullous or ...
Breaking Medicine Technology:Orthopaedic Surgery Reimbursement Shifts to Episode of Care 2Medimetriks Pharmaceuticals, Inc. Announces Completion of the Second Successful Pivotal Phase III Study for Ozenoxacin 2Medimetriks Pharmaceuticals, Inc. Announces Completion of the Second Successful Pivotal Phase III Study for Ozenoxacin 3
An enzyme linked immunoassay (ELISA) for the detection and semiquantitationof IgG and IgM antibodies to 2-GP1, as an aid in assessingthe risk of thrombosis in patients with Systemic Lupus Erythematos...
An enzyme linked immunoassay (ELISA) for the detection and semiquantitation of IgG, IgA or IgM anticardiolipin antibodies, as an aid in assessing the risk of thrombosis in individuals with Systemic L...
The ImagingPlanet 70 mm surgical microscope video adapter: superior optical quality and precise engineering make this 70 mm focal length adapter an excellent decision for use with your Zeiss surgical...
The ImagingPlanet 55 mm surgical microscope video adapter: superior optical quality and precise engineering make this 55mm focal length adapter an excellent decision for use with your Leica surgical ...
Medicine Products: