Navigation Links
Switching immunosuppressants reduces cancer risk in kidney
Date:10/31/2009

Switching to a newer type of immunosuppressant drug may reduce the high rate of skin cancer after kidney transplantation, according to research being presented at the American Society of Nephrology's 42nd Annual Meeting and Scientific Exposition in San Diego, CA.

"In spite of the life-saving nature of organ transplantation, the need for transplant recipients to continue treatment with drugs that suppress the immune system to prevent rejection of the organ is associated with a number of side effects, one of which is the development of cancer," said lead researcher Graeme Russ, MD (The Queen Elizabeth Hospital, Australia). "So the search for an immunosuppressive drug which prevents rejection effectively but is associated with lower rates of cancer will be of significant advantage to transplant recipients."

The study included 86 kidney transplant patients who previously had skin cancer (other than melanoma)placing them at particularly high risk of new skin cancers. In Australia, skin cancer is the most common type of cancer occurring post-transplant.

One group of patients remained on standard immunosuppressant drug treatment. The other group was switched to treatment with sirolimusone of a newer class of immunosuppressants called mTOR inhibitors. "Previous studies have suggested that mTOR inhibitors are associated with less cancer than other commonly used agents," according to Russ.

Patients switched to sirolimus had a significantly lower rate of new skin cancers. Overall, new skin cancers developed in 56 percent of patients in the sirolimus group, compared to 81 percent of those who remained on the standard immunosuppressant. Most of the difference reflected a lower rate of one type of cancer, called squamous cell carcinoma.

Nearly half of patients stopped taking sirolimus because of side effects. "In spite of this large dropout rate there was a significantly lower rate of skin cancer development in the sirolimus group," said Russ. Switching to sirolimus did not increase the risk of rejection of the transplanted kidney.

Switching immunosuppressants may offer a new option to reduce the high risk of skin cancer for transplant recipients, the researchers believe. Russ added, "This is the first randomized controlled trial to address whether patients treated with mTOR inhibitors after renal transplantation have less skin cancer."


'/>"/>

Contact: Shari Leventhal
sleventhal@asn-online.org
202-558-8423
American Society of Nephrology
Source:Eurekalert  

Related medicine news :

1. Switching early breast cancer patients to exemestane improves long-term survival
2. AUDIO from Medialink and Forest Laboratories: Dangers of Switching Medications
3. For Treatment of Dyslipidemia, Surveyed Physicians are Increasingly Switching Patients to a More Potent Statin Following the ENHANCE and SEAS Trials
4. National Pharmacy Omnicare Pays 'Unusual' Settlement to Resolve Charges of Generic Drug Switching in Delaware Nursing Homes, Resulting From 'Qui Tam' Lawsuit
5. Senator Specter: Switching Parties or Coming Home?
6. Patients Urged to be Aware of Prescription Switching
7. Medicare Advantage Open Enrollment Offers One-Time Chance to Change Your Mind: Allsup Outlines Rules for Switching Plans
8. Walgreens Pays $35 Million, Settles Pharmacist-Whistleblower Qui Tam Drug Switching Allegations
9. Attorney General Corbett Announces $36.7 Million Multi-State Settlement With CVS/Caremark in National Dosage-Switching Investigation
10. CVS, Americas Largest Pharmacy Chain, Pays Nearly $37 Million to Settle Federal and State Generic Drug Switching Charges
11. Switching to MA Coverage Unlikely for Current Beneficiaries With MediGap or Medicare Only
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Switching immunosuppressants reduces cancer risk in kidney
(Date:12/8/2016)... ... December 08, 2016 , ... Premier Fitness Camp (PFC) and The ... ultimate weight loss and wellness program, at their world headquarters of Omni La Costa ... and long-term results to anyone seeking weight loss, personal development, a healthy lifestyle, or ...
(Date:12/8/2016)... ... , ... STATEN ISLAND, N.Y., Nov. 24, 2016 — ... standards of trauma, maternity, cancer and chronic obstructive pulmonary disease (COPD) services from ... Messina. , Among the recognitions, the American College of Surgeons' (ACS) named the ...
(Date:12/8/2016)... ... December 08, 2016 , ... Healthcare is in flux. ... advocates for the mass media launching of story movements to highlight what's most ... their unfortunate experiences; such a movement can generate the network power to improve ...
(Date:12/8/2016)... ... December 08, 2016 , ... ... services from offices headquartered in Jefferson County, is announcing the launch of a ... Birmingham. , The number of homeless women and children in Birmingham has grown ...
(Date:12/8/2016)... (PRWEB) , ... December 08, 2016 , ... ... and financial consulting services to residential and commercial clients in the northern Alabama ... support for Nobis Works. , Since 1977, Nobis Works has built a network ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... , December 8, 2016 Information products ... metrics in Scopus , the world,s largest abstract ... access to comprehensive metrics for journals from over 5,000 publishers. The ... which journals to subscribe to and when to adjust a journal,s ... , , ...
(Date:12/8/2016)... ALBANY, New York , December 8, 2016 ... the global Diabetes Injection Pens Market is expected ... as compared to US$4.9 bn in 2015. Between the forecast ... to rise at a CAGR of 7.9%. The leading players ... Nordisk A/S, Eli Lilly and Company, AstraZaneca plc., Biocon Ltd., ...
(Date:12/8/2016)... 2016 According to a new market research report ... Therapeutic (Pain, Insulin)), End Use (Sports, Fitness, RPM), Type (Smart watch, Patch), ... global market, in terms of value, is projected to reach 12.14 Billion ... 18.0% during the forecast period. Continue Reading ... ...
Breaking Medicine Technology: