Navigation Links
Switching early breast cancer patients to exemestane improves long-term survival
Date:9/21/2009

e years of treatment. The results presented in Berlin update findings reported previously, providing evidence based on a longer follow-up to produce a more robust estimate of the strategy's effect on survival and disease recurrence and give a clearer picture of the long-term side effects.

"Our earlier analysis, based on a shorter follow-up, had shown a clear relapse advantage but until now, the magnitude and duration of the overall survival benefit had been uncertain. These updated results show that the relapse improvement does not seem to diminish over time and have clarified that the survival advantage is robust and enduring."

The study, which has the longest follow-up of any trial to date investigating the impact of switching from tamoxifen to an aromatase inhibitor, involved 4,724 postmenopausal women from 37 countries with oestrogen-receptor-positive or unknown receptor status breast cancer who had their tumours cut out and had remained disease free after two or three years on tamoxifen. About half continued with tamoxifen until they had completed a total of five years of treatment, while the other half were switched to exemestane for the remaining period of treatment. The women were followed for an average of 91 months.

The 18% improvement in disease-free survival is derived from a hazard ratio of 0.82, while the 14% improvement in overall survival is calculated from a hazard ratio of 0.86.

"Practice changed in many countries after our early findings were released in 2004, from using five years of tamoxifen to the current recommended treatment strategy of switching these patients to exemestane or another aromatase inhibitor after two or three years of tamoxifen. The issue that has yet to be clarified is whether starting with tamoxifen and then switching is better than starting with an aromatase inhibitor," Prof Coombes said.

Cancer Research UK and Pfizer Ltd., which makes exemestane, funded the study.


'/>"/>
Contact: Emma Ross
rosswrite@mac.com
ECCO-the European CanCer Organisation
Source:Eurekalert

Page: 1 2

Related medicine news :

1. AUDIO from Medialink and Forest Laboratories: Dangers of Switching Medications
2. For Treatment of Dyslipidemia, Surveyed Physicians are Increasingly Switching Patients to a More Potent Statin Following the ENHANCE and SEAS Trials
3. National Pharmacy Omnicare Pays 'Unusual' Settlement to Resolve Charges of Generic Drug Switching in Delaware Nursing Homes, Resulting From 'Qui Tam' Lawsuit
4. Senator Specter: Switching Parties or Coming Home?
5. Patients Urged to be Aware of Prescription Switching
6. Medicare Advantage Open Enrollment Offers One-Time Chance to Change Your Mind: Allsup Outlines Rules for Switching Plans
7. Walgreens Pays $35 Million, Settles Pharmacist-Whistleblower Qui Tam Drug Switching Allegations
8. Attorney General Corbett Announces $36.7 Million Multi-State Settlement With CVS/Caremark in National Dosage-Switching Investigation
9. CVS, Americas Largest Pharmacy Chain, Pays Nearly $37 Million to Settle Federal and State Generic Drug Switching Charges
10. Switching to MA Coverage Unlikely for Current Beneficiaries With MediGap or Medicare Only
11. LA County Announces: Nearly 40,000 Seniors and Disabled to Lose Home Care Service Hours Due to State Budget Cuts
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/2/2015)... 2015 Robins & Morton Celebrates Women ... Women in Construction Week (March 1-7, sponsored by the ... National Women’s History Month, Robins & Morton is recognizing ... company and the construction industry as a whole. From ... dozens of roles in between, each woman has a ...
(Date:3/2/2015)... 2015 The Workgroup for Electronic Data ... use of health IT to create efficiencies in healthcare ... for Small Providers.” The white paper by WEDI’s ICD-10 ... for ICD-10 testing by focusing on primary considerations and ... with the October 1, 2015 implementation date. Download the ...
(Date:3/2/2015)... March 02, 2015 This year, the National ... and will provide opportunities for people across the country to ... help people with MS live their best lives. MS Awareness ... to inspire others to join the Society’s vision of a ... unpredictable, often disabling disease of the central nervous system, interrupts ...
(Date:3/2/2015)... 2015 Four Seasons Resort Maui at Wailea, ... anniversary this year, having officially opened its doors on March ... is honoring over 70 employees who started on Day 1 ... the approximately 400 original employees. The celebration will be ... , This Four Seasons flagship resort, the first ...
(Date:3/2/2015)... What are the best practices for writing a ... interviews scheduled, how can physicians best prepare, and how ... physicians who are looking for new opportunities can learn ... PracticeLink Physician Career Advancement Workshop and Job Fair on ... 5:30 to 8:30 p.m. at the Marriott-Texas Medical Center ...
Breaking Medicine News(10 mins):Health News:Robins & Morton Recognizes Women In Construction 2Health News:WEDI Releases New White Paper on ICD-10 Testing for Small Providers 2Health News:Every Connection Counts During MS Awareness Week 2Health News:Every Connection Counts During MS Awareness Week 3Health News:Every Connection Counts During MS Awareness Week 4Health News:Celebrating Four Seasons Resort Maui’s 25th Anniversary 2Health News:PracticeLink to Host a Career Advancement Workshop and Job Fair in Houston 2
... Ablation Frontiers, Inc., a,privately-held medical device company, ... using the company,s Tip-Versatile Ablation,Catheter(TM) (T-VAC). Dr. ... in,Chertsey, United Kingdom is one of three ... new multi-electrode linear ablation catheter since,November 2007. ...
... One of Australia,s largest,pharmacy groups, Chemmart, has introduced a ... posed by discount chains., The system was launched ... participating pharmacies signed up more than 30,000 Chemmart,"rewards" members., ... has now been,rolled out to more than 160 Chemmart ...
... 16 The Ninth Annual Renal Teen,Prom, "Winter ... is,to be held Sunday, January 20, 2008 at ... unique event attracts more than 350 kidney teens,(ages ... a transplant, and,their guests, coming from Washington D.C., ...
... Americans consume more calories as a,nation on Super Bowl Sunday ... the time the final whistle blows at Super Bowl XLII,Americans ... chicken wings, and beer., But this year you have ... field 109 times to burn off all of those extra ...
... life for kids with moderate to severe disease, , , ... significantly improved psoriasis symptoms in children under 17 with ... The study found that 57 percent of the children ... a 75 percent improvement in their symptoms, and their ...
... a 23% reduced risk of falling in winter, spring ... may help reduce the risk of falls among high-risk elderly ... than 65 fall each year, and six percent sustain a ... of falling is a major problem in older people," according ...
Cached Medicine News:Health News:Speedy Procedures Demonstrate Excitement and Continued Interest in Novel Multi-Electrode Ablation System 2Health News:Chemmart(R) Sees Instant Results From Launch of New Rewards Program 2Health News:Celebrities to Attend the Ninth Annual Kidney Teen Prom 2Health News:Eat This, Not That!(TM): 5 Smart Super Bowl Swaps That Will Save You Hundreds of Calories 2Health News:Adult Drug Effective in Treating Psoriasis in Children 2Health News:Adult Drug Effective in Treating Psoriasis in Children 3Health News:Vitamin D May Curb Falls in High-Risk Older Women 2
(Date:3/2/2015)... BETHESDA, Md. , March 2, 2015 ... on treating and preventing autoimmune diseases, announced today that ... (AMG 714) from Amgen (NASDAQ: AMGN ). ... has the rights to develop, manufacture and commercialize AMG ... . Concurrently, Amgen has been granted an exclusive ...
(Date:3/2/2015)... Texas , March 2, 2015   Lexicon ... biopharmaceutical company focused on developing breakthrough treatments for human ... 2014 financial results on Wednesday, March 4, 2015 before ... conference call and webcast to discuss clinical development progress ... end of 2014 at 10:00 a.m. Eastern Time on ...
(Date:3/2/2015)... 2, 2015  BioMed Realty Trust, Inc. (NYSE: ... 313,000 square feet of space in the most dynamic ... world through the termination of Vertex Pharmaceuticals, leases on ... effective February 28, 2015. BioMed Realty will receive a ... begin to reposition the properties to meet the growing ...
Breaking Medicine Technology:Celimmune Announces Anti-IL-15 Antibody Licensing and Option Agreements with Amgen 2Celimmune Announces Anti-IL-15 Antibody Licensing and Option Agreements with Amgen 3Lexicon To Report Fourth Quarter And Year End 2014 Financial Results On March 4, 2015 2BioMed Realty Gets Back 313,000 Square Feet Of Valuable Real Estate In Cambridge Innovation District 2BioMed Realty Gets Back 313,000 Square Feet Of Valuable Real Estate In Cambridge Innovation District 3
... 13 Anadys Pharmaceuticals, Inc. (Nasdaq: ANDS ) ... Annual Healthcare Conference on Friday, September 17, 2010 at 8:35 ... at the Four Seasons in Boston.  Steve Worland, Ph.D., President ... of Anadys and its clinical development programs. Dr. ...
... Amgen (Nasdaq: AMGN ) will participate in ... the St. Regis New York in New York City, beginning ... president of Global Development, for Amgen, will present at the ... the Internet and can be accessed from Amgen,s website, ...
Cached Medicine Technology:Anadys Pharmaceuticals to Present at Two Upcoming Investor Conferences 2
... nebulizer system offers an affordable and ... COPD or other respiratory conditions. The ... gives patients the ability to take ... Its unique nebulizer design delivers powerful ...
... The most compact, portable DC powered ... Elite provides the freedom to take ... system is powered by the included ... Adapter and Battery Kit. The integral ...
... The 50 psi MaxiCompressor, the ... to run 24 hours a ... It features a tamper-proof locking ... unintentional increases or decreases in ...
... PulmoStar is a low cost compressor/nebuliser which offers ... the home, health centre or clinic. The SunMist ... and a simple filter change every six months., ... With Disposable Neb, 3 Prong Polarized plug With ...
Medicine Products: