Navigation Links
Switch for Internal Body Clock Found
Date:12/12/2007

Discovery could lead to new treatments for sleep disorders

WEDNESDAY, Dec. 12 (HealthDay News) -- The chemical switch that activates the genetic mechanism regulating the body's internal clock has been identified by University of California, Irvine, researchers.

They added that the switch offers a target for the development of new drugs to treat sleep disorders and related problems.

The study found that a single amino acid triggers the genes that regulate circadian rhythms. Because of the complex genes involved, the researchers said they were surprised to find that a single amino acid switched on the body clock mechanism.

A modification in a single amino acid in the BMAL1 protein activates the genetic processes involved with circadian rhythms, the researchers found. If this amino acid modification goes awry, the genetic switching mechanism can malfunction, resulting in circadian rhythm-related disorders.

"Because the triggering action is so specific, it appears to be a perfect target for compounds that could regulate this activity. It is always amazing to see how molecular control is so precise in biology," study author Paolo Sassone-Corsi, Distinguished Professor and Chair of Pharmacology, said in a prepared statement.

Sassone-Corsi is currently testing antibodies that can target the activity of this amino acid in the BMAL1 protein.

The study is published in the Dec. 13 issue of Nature.

More information

The Medical College of Wisconsin has more about circadian rhythms.



-- Robert Preidt



SOURCE: University of California, Irvine, news release, Dec. 12, 2007


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved

Page: 1

Related medicine news :

1. Schizophrenia Gene May Have On/Off Switch
2. Brain Switch Helps Doctors Deal With Patients Pain
3. Switching to MA Coverage Unlikely for Current Beneficiaries With MediGap or Medicare Only
4. Scientists Spot Eye Development Switch
5. A molecular switch is linked to a common breast cancer
6. Researchers identify unusual molecular switch for common form of advanced breast cancer
7. Cell Structure Helps Direct Cancer Gene Switch
8. Childrens Hospital researchers identify molecular switch that could save very young lives
9. Protein-dependent switch regulates intracellular trafficking in epithelial cells
10. Annals of Internal Medicine tip sheet for Aug. 21, 2007, issue
11. Pharmaceutical Manufacturing Quality: Optimizing Your Internal Process for FDA Compliance
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... ... “America On The Brink”: the Christian history of the United States and the ... published author, William Nowers. Captain Nowers and his wife, Millie, have six children, ... in the Navy. Following his career as a naval aviator and carrier pilot, ...
(Date:10/12/2017)... ... October 12, 2017 , ... CitiDent and San Francisco ... using cutting-edge Oventus O2Vent technology. As many as 18 million Americans are estimated ... in breathing. Oral appliances can offer significant relief to about 75 percent of ...
(Date:10/12/2017)... ... October 12, 2017 , ... The ... demand of today’s consumer and regulatory authorities worldwide. From Children’s to Adults 50+, ... to meet the highest standard. , These products are also: Gluten Free, ...
(Date:10/12/2017)... Bethesda, MD (PRWEB) , ... October 12, 2017 , ... ... Award of Excellence to Carol Friedman, PhD, FACMI, during the Opening Session of AMIA’s ... 4 – 8. , In honor of Morris F. Collen, a pioneer in the ...
(Date:10/12/2017)... Maryland (PRWEB) , ... October 12, 2017 , ... ... magnetic drug delivery system that we intend to develop to enable prevention of ... can lead to severe hearing loss, especially in pediatric patients. For cisplatin, hearing ...
Breaking Medicine News(10 mins):
(Date:9/22/2017)... -- As the latest Obamacare repeal effort moves is debated, ... and Lindsey Graham (R-SC) medical device market ... is in an odd place.  The industry wants repeal ... on medical device sales passed along with the Affordable ... visits and hospital customers with the funding to invest ...
(Date:9/19/2017)... 2017 HistoSonics, Inc., a venture-backed medical device company developing a non-invasive, robotically assisted, ... three leadership team developments today:   ... ... Tom Tefft ... Veteran medical device executive Josh Stopek , PhD, who has ...
(Date:9/18/2017)... ALLENTOWN , Pa. and KALAMAZOO, Mich. ... Allentown, Penn. , and OptiMed Specialty Pharmacy ... a business partnership to offer a strategic hub service ... PMD Healthcare,s highly sought-after personal spirometer, Spiro PD 2.0, ... A spirometer is a medical device used ...
Breaking Medicine Technology: