Navigation Links
Switch for Internal Body Clock Found
Date:12/12/2007

Discovery could lead to new treatments for sleep disorders

WEDNESDAY, Dec. 12 (HealthDay News) -- The chemical switch that activates the genetic mechanism regulating the body's internal clock has been identified by University of California, Irvine, researchers.

They added that the switch offers a target for the development of new drugs to treat sleep disorders and related problems.

The study found that a single amino acid triggers the genes that regulate circadian rhythms. Because of the complex genes involved, the researchers said they were surprised to find that a single amino acid switched on the body clock mechanism.

A modification in a single amino acid in the BMAL1 protein activates the genetic processes involved with circadian rhythms, the researchers found. If this amino acid modification goes awry, the genetic switching mechanism can malfunction, resulting in circadian rhythm-related disorders.

"Because the triggering action is so specific, it appears to be a perfect target for compounds that could regulate this activity. It is always amazing to see how molecular control is so precise in biology," study author Paolo Sassone-Corsi, Distinguished Professor and Chair of Pharmacology, said in a prepared statement.

Sassone-Corsi is currently testing antibodies that can target the activity of this amino acid in the BMAL1 protein.

The study is published in the Dec. 13 issue of Nature.

More information

The Medical College of Wisconsin has more about circadian rhythms.



-- Robert Preidt



SOURCE: University of California, Irvine, news release, Dec. 12, 2007


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved

Page: 1

Related medicine news :

1. Schizophrenia Gene May Have On/Off Switch
2. Brain Switch Helps Doctors Deal With Patients Pain
3. Switching to MA Coverage Unlikely for Current Beneficiaries With MediGap or Medicare Only
4. Scientists Spot Eye Development Switch
5. A molecular switch is linked to a common breast cancer
6. Researchers identify unusual molecular switch for common form of advanced breast cancer
7. Cell Structure Helps Direct Cancer Gene Switch
8. Childrens Hospital researchers identify molecular switch that could save very young lives
9. Protein-dependent switch regulates intracellular trafficking in epithelial cells
10. Annals of Internal Medicine tip sheet for Aug. 21, 2007, issue
11. Pharmaceutical Manufacturing Quality: Optimizing Your Internal Process for FDA Compliance
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/13/2016)... ... , ... Valentine’s Day is nearly upon us, and most singles could probably ... flawless hair, and a sparkling personality are all well and good, but if somebody ... home with Rover. (Actually, man’s best friend might not even want to be near ...
(Date:2/13/2016)... ... February 13, 2016 , ... In its newly ... vein visualization technology should be used to ensure patient safety when placing an ... INS Standards mandate the use of vein visualization technology in patients with difficult ...
(Date:2/12/2016)... ... 12, 2016 , ... According to an article published February 4th ... significant portion of hernia repairs throughout the United States. Commenting on this article, Beverly ... that this trend has not only been expected, but it seems to be a ...
(Date:2/12/2016)... ... February 12, 2016 , ... CDRH Enforcement Trends: , Back to the Future , ... , As Winston Churchill said, “Those who don’t learn from history are doomed to ... expect when they come knocking this year. But that takes time. , Take a ...
(Date:2/12/2016)... ... February 12, 2016 , ... T.E.N., a ... closed for the ISE Southeast Awards 2016. Finalists and winners of the ISE® ... Southeast Executive Forum and Awards Gala on March 15, 2016 at the Westin ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)... 12 2016  OMS Supply, a large provider of ... announced today the recent launching of their new company ... of features that enhance the user experience and enable ... --> --> Despite ... company that started in early 2016, they have already ...
(Date:2/11/2016)... Feb. 11, 2016 - ... in Personalized Medicine and Cancer Therapy. - European ... Diagnostic Testing Markets. - Key Diagnostic Testing Markets. ... Molecular Diagnostics in Genetic Testing. - Molecular Diagnostics ... - Over-the-Counter Diagnostic Products World Markets. - ...
(Date:2/11/2016)... -- Kindred Biosciences, Inc. (NASDAQ: KIN ), a biopharmaceutical ... pets, today announced the submission to FDA of the ... (NADA) for Zimeta™ (dipyrone injection, KIND-012).  Positive topline results ... the control of pyrexia (fever) in horses were recently ... --> The Chemistry, Manufacturing, and Controls technical ...
Breaking Medicine Technology: