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Swine Flu Hits Sick People the Hardest: CDC
Date:5/20/2009

Meanwhile, vaccine won't be ready for months, World Health Organization says

WEDNESDAY, May 20 (HealthDay News) -- Underscoring the belief that the new H1N1 swine flu is no more dangerous than regular flu, U.S. health officials said Tuesday that those hospitalized with the infection who have underlying health problems fare worse than otherwise healthy people who also have been hospitalized.

And that mirrors trends seen with seasonal -- or regular -- flu, officials said.

In an early release of the U.S. Centers for Disease Control and Prevention's journal Morbidity and Mortality Weekly Report, California health authorities assessed 30 people hospitalized for the H1N1 swine flu. One difference between these patients and patients with seasonal flu was their average age. At 27, the swine flu patients were much younger than most patients with seasonal flu who required hospitalization.

Health officials in both the United States and abroad have previously reported that the H1N1 swine flu seems to be targeting teens and young adults, unlike the regular flu, which usually strikes hardest at the elderly and the very young.

Also, about two-thirds of the hospitalized patients in California had at least one underlying medical condition that put them at higher risk for influenza and its complications, Dr. Anne Schuchat, the CDC's interim deputy director for science and public health program, said during an afternoon teleconference. "The most common conditions were chronic lung disease, conditions associated with immunosuppression, chronic heart disease, obesity and pregnancy. There were five pregnant women in this series of patients," she said.

"Although the majority of hospitalized people infected with this new H1N1 virus recovered without complications, certain people did have severe and prolonged disease," Schuchat said. "None of these patients died. There are still some of these patients in the hospital, so we don't know whether they will make it or not."

Meanwhile, the World Health Organization said Tuesday that production of an H1N1 swine flu vaccine could not begin until mid-July at the earliest, which is weeks later than previous estimates. It would then take months before a vaccine would be available, the Associated Press reported.

The reason: swine flu virus isn't growing very fast in laboratories, making it hard for scientists to get the key ingredient they need for a vaccine -- the "seed stock" from the virus, WHO officials said, the AP reported.

Vaccine experts estimated that, under the best of conditions, they could produce nearly 5 billion doses of swine flu vaccine over a year after beginning full-scale production.

The WHO's director-general, Dr. Margaret Chan, said it would be impossible to produce enough vaccine for all 6.8 billion people on the planet -- a potential scenario that could pit rich countries against poorer ones as they bid for the vaccine, the AP said.

WHO officials are meeting this week at their headquarters in Geneva, Switzerland, with representatives from about 30 drug companies to discuss the potential need for a vaccine and how best to produce it.

One factor complicating a decision on a swine flu vaccine is that most flu vaccine companies can only make limited amounts of both seasonal flu vaccine and pandemic vaccine, such as that needed for swine flu, and not at the same time. The producers also can't make large quantities of both types of vaccine because that would exceed manufacturing capacity.

Testing has found that the swine flu virus remains susceptible to two common antiviral drugs, Tamiflu and Relenza, according to the CDC.

In the United States, while most cases of swine flu continue to be no worse than seasonal flu, the death rate from the new H1N1 virus is slightly higher than that seen with seasonal flu, U.S. health officials said Monday.

"Our best estimate right now is that the fatality [rate] is likely a little bit higher than seasonal influenza, but not necessarily substantially higher," Schuchat said.

Schuchat added that the spread of the swine flu is far from over and could continue through the summer. "H1N1 is not going away, despite what you've heard," she said.

On Tuesday, the CDC was reporting 5,469 U.S. cases of swine flu in 48 states, and six deaths. Health officials said a Missouri man with swine flu had died, and testing was being done to see if the disease caused his death. Also, New York City health officials said they were investigating the death of a 16-month-old boy to determine if swine flu was the cause.

The World Health Organization on Wednesday was reporting 10, 243 diagnosed cases in 41 countries, including at least 80 deaths, mostly in Mexico, believed to be the source of the outbreak.

The swine flu is a highly unusual mix of swine, bird and human flu viruses. Experts worry that, if the new flu virus mutates, people would have limited immunity to fight the infection.

The CDC is concerned with what will happen as the H1N1 virus moves into the Southern Hemisphere, where the flu season is about to start. The agency is also preparing for the virus' likely return in the fall to the Northern Hemisphere.

U.S. Human Cases of H1N1 Flu Infection
(As of May 19, 2009, 11:00 AM ET)
States # of
confirmed and
probable cases
Deaths
Alabama
61 cases
 
Arkansas
3 cases
 
Arizona
488 cases
2 deaths
California
553 cases
 
Colorado
56 cases
 
Connecticut
56 cases
 
Delaware
69 cases
 
Florida
103 cases
 
Georgia
25 cases
 
Hawaii
21 cases
 
Idaho
8 cases
 
Illinois
707 cases
 
Indiana
96 cases
 
Iowa
71 cases
 
Kansas
34 cases
 
Kentucky**
16 cases
 
Louisiana
65 cases
 
Maine
10 cases
 
Maryland
39 cases
 
Massachusetts
156 cases
 
Michigan
165 cases
 
Minnesota
38 cases
 
Mississippi
4 cases
 
Missouri
20 cases
 
Montana
9 cases
 
Nebraska
28 cases
 
Nevada
31 cases
 
New Hampshire
20 cases
 
New Jersey
18 cases
 
New Mexico
68 cases
 
New York
267 cases
 
North Carolina
12 cases
 
North Dakota
3 cases
 
Ohio
13 cases
 
Oklahoma
42 cases
 
Oregon
94 cases
 
Pennsylvania
55 cases
 
Rhode Island
8 cases
 
South Carolina
36 cases
 
South Dakota
4 cases
 
Tennessee
85 cases
 
Texas
556 cases
3 deaths
Utah
91 cases
 
Vermont
1 case
 
Virginia
23 cases
 
Washington
362 cases
1 death
Washington, D.C.
13 cases
 
Wisconsin
766 cases
 
TOTAL*(48)
5,469 cases
6 deaths
*includes the District of Columbia
**One case is resident of Ky. but hospitalized in Ga.

Source: U.S. Centers for Disease Control and Prevention

More information

For more on swine flu, visit the U.S. Centers for Disease Control and Prevention.



SOURCES: May 19, 2009, teleconference with Anne Schuchat, M.D., Interim Deputy Director for Science and Public Health Program, U.S. Centers for Disease Control and Prevention; Associated Press


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