Navigation Links
Swelling After Knee Injury May Hinder Healing
Date:8/31/2007

Pig study shows blocking 2 proteins could mean less invasive treatment of meniscus damage

FRIDAY, Aug. 31 (HealthDay News) -- The swelling that normally occurs when a joint is injured may interfere with healing after knee injuries, researchers say.

Publishing in the September issue of Arthritis & Rheumatism, Duke University researchers identified two immune system proteins -- interleuken-1 and tumor necrosis factor -- produced by the body during swelling that blocked the healing of a damaged pig meniscus. The meniscus is a type of cartilage inside the knee joint that acts as a shock absorber between the thigh bone and lower leg bone. Almost 15 percent of all athletic injuries to the knee involve the meniscus. Over time, wear and tear on this cartilage contributes to osteoarthritis.

Medical treatments could be used to block interleuken-1 and tumor necrosis factor and help heal knee injuries and osteoarthritis, the researchers said.

"There already is a drug that blocks the effects of tumor necrosis factor that is used widely and effectively in patients with rheumatoid arthritis, the form of the disease caused by body's own immune system attacking the joint," senior researcher Farshid Guilak said in a prepared statement. "Another drug also exists that blocks IL-1 that is being used for rheumatoid arthritis and is currently undergoing clinical trials for osteoarthritis."

The Duke team exposed pig knees to varying levels of the two proteins. As they increased the dose amount, the meniscus tissue became less able to repair itself. The range of concentrations in the experiment match those found in the joints of humans with rheumatoid arthritis and osteoarthritis.

The majority of meniscus injuries are tears in the tissue. If the tear is small and occurs outside the meniscus, it can be repaired surgically, although surgical repairs are not always effective. A large tear may mean surgeons have to remove the torn tissue entirely, which speeds the progression of osteoarthritis.

These findings, the team said, could result in a targeted, less invasive way to manage meniscus damage.

More information

To learn more about meniscal injuries, visit A Patient's Guide to Meniscal Injuries.



-- Madeline Vann



SOURCE: Duke University, news release, Aug. 30, 2007


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Swelling increases stroke risk with high B.P.
2. Do Not Neglect Your Abdominal Pain/ Swelling - Help Your Doctor In Early Cancer Detection
3. Brain Swelling Key to Reducing Stroke Fatalities
4. Swelling of Prostate Gland Prevented with New drug
5. Surgeon Develops Procedure to Prevent Arm Swelling in Breast Cancer Patients
6. Brain Swelling Halts Conjoined Twin Surgery
7. Thyroid hormone treatment hastens recovery after cardiac surgery
8. Morning after pill effective up to five days after having unprotected sex
9. Liver donors can thrive after transplant
10. Recouping blood flow after a stroke
11. Quality of life after cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/22/2017)... ... March 22, 2017 , ... Sam ... insurance assistance, financial planning, and related services to residents of the region, is ... awareness of threatened species and wild lands. , Endangered Species International is committed ...
(Date:3/22/2017)... San Jose, CA (PRWEB) , ... March 22, ... ... of San Jose, Santa Cruz and Milpitas with a robust, ongoing community enrichment ... Supportive Housing (FSH), a nonprofit organization which has provided for the critical needs ...
(Date:3/22/2017)... ... 2017 , ... The American Society for Preventive Cardiology ... for prescribers to improve patients’ access to the revolutionary therapy for appropriate patients ... of the article entitled “PCSK9 Inhibitor Access Barriers: Issues and Recommendations: Improving ...
(Date:3/22/2017)... ... March 22, 2017 , ... Old School Labs™, makers of ... Theophane as a new Brand Ambassador. Theophane, who trained with Floyd Mayweather, made his ... 2011. He has racked up an impressive number of wins in contests in Britain, ...
(Date:3/22/2017)... Georgia (PRWEB) , ... March 22, 2017 , ... ... time consuming and frustrating and this tool bypasses that. Healthcare facilities across ... identified an opportunity to offer their clients and hospitals, across the country, an ...
Breaking Medicine News(10 mins):
(Date:3/22/2017)... RADNOR, Pennsylvania , 22 de marzo de ... proveedor independiente global líder de soluciones de productos ... ha anunciado hoy que ha adquirido EPL Archives, ... apoya a los clientes en todo el ciclo ... y comercialización ofreciendo una muestra de archivo, almacenamiento ...
(Date:3/22/2017)... DUBLIN , Mar. 22, 2017 Research ... Care Devices Market Analysis & Trends - Industry Forecast to 2025" ... ... to grow at a CAGR of around 10.9% over the next ... This industry report analyzes the market estimates and forecasts for all ...
(Date:3/22/2017)... -- DarioHealth Corp. (NASDAQ: DRIO), a leading global digital ... solutions, today reported financial and operational results for ... 31, 2016. 2016 Highlights ... compared to the full year 2015  ... year  Direct-to-consumer model launched in ...
Breaking Medicine Technology: