Navigation Links
Swelling After Knee Injury May Hinder Healing
Date:8/31/2007

Pig study shows blocking 2 proteins could mean less invasive treatment of meniscus damage

FRIDAY, Aug. 31 (HealthDay News) -- The swelling that normally occurs when a joint is injured may interfere with healing after knee injuries, researchers say.

Publishing in the September issue of Arthritis & Rheumatism, Duke University researchers identified two immune system proteins -- interleuken-1 and tumor necrosis factor -- produced by the body during swelling that blocked the healing of a damaged pig meniscus. The meniscus is a type of cartilage inside the knee joint that acts as a shock absorber between the thigh bone and lower leg bone. Almost 15 percent of all athletic injuries to the knee involve the meniscus. Over time, wear and tear on this cartilage contributes to osteoarthritis.

Medical treatments could be used to block interleuken-1 and tumor necrosis factor and help heal knee injuries and osteoarthritis, the researchers said.

"There already is a drug that blocks the effects of tumor necrosis factor that is used widely and effectively in patients with rheumatoid arthritis, the form of the disease caused by body's own immune system attacking the joint," senior researcher Farshid Guilak said in a prepared statement. "Another drug also exists that blocks IL-1 that is being used for rheumatoid arthritis and is currently undergoing clinical trials for osteoarthritis."

The Duke team exposed pig knees to varying levels of the two proteins. As they increased the dose amount, the meniscus tissue became less able to repair itself. The range of concentrations in the experiment match those found in the joints of humans with rheumatoid arthritis and osteoarthritis.

The majority of meniscus injuries are tears in the tissue. If the tear is small and occurs outside the meniscus, it can be repaired surgically, although surgical repairs are not always effective. A large tear may mean surgeons have to remove the torn tissue entirely, which speeds the progression of osteoarthritis.

These findings, the team said, could result in a targeted, less invasive way to manage meniscus damage.

More information

To learn more about meniscal injuries, visit A Patient's Guide to Meniscal Injuries.



-- Madeline Vann



SOURCE: Duke University, news release, Aug. 30, 2007


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Swelling increases stroke risk with high B.P.
2. Do Not Neglect Your Abdominal Pain/ Swelling - Help Your Doctor In Early Cancer Detection
3. Brain Swelling Key to Reducing Stroke Fatalities
4. Swelling of Prostate Gland Prevented with New drug
5. Surgeon Develops Procedure to Prevent Arm Swelling in Breast Cancer Patients
6. Brain Swelling Halts Conjoined Twin Surgery
7. Thyroid hormone treatment hastens recovery after cardiac surgery
8. Morning after pill effective up to five days after having unprotected sex
9. Liver donors can thrive after transplant
10. Recouping blood flow after a stroke
11. Quality of life after cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/18/2017)... ... January 18, 2017 , ... At Hallmark Nameplate, their commitment ... they have achieved certification to ISO 13485. This certification is another way they are ... date products and services that they need. , The ISO 13485 Certification is a ...
(Date:1/18/2017)... ... January 18, 2017 , ... Rollerblade®, the worldwide ... (ABT), an innovative braking system that allows skaters of all levels to stop ... the biggest concerns of beginner and intermediate skaters – learning how to brake ...
(Date:1/17/2017)... NY (PRWEB) , ... January 17, 2017 , ... Gym ... opening of a new showroom at South Dixie Hwy in Miami, FL. , “We ... at Gym Source. “The new innovative in-store concept is designed to give clients a ...
(Date:1/17/2017)... , ... January 17, 2017 , ... SunView Software’s Service ... for Innovation of the Year. , Each year, Pink Elephant recognizes a ... innovative approach to address a specific business problem or opportunity. The award highlights original ...
(Date:1/17/2017)... (PRWEB) , ... January 17, 2017 , ... Mirror Mirror ... earned the highest honor of Diamond Level in Zeltiq’s Crystal Rewards Program. Practice founder, ... part of this elite group of providers. , Produced by Zeltiq, CoolSculpting is ...
Breaking Medicine News(10 mins):
(Date:1/18/2017)... , Jan. 18, 2017 The Philadelphia Pediatric Medical ... developing medical devices for children. The Consortium chose ... seed grants of $50,000 each. The devices under ... nerve signals, a hand-operated rapid blood delivery system for emergency ... babies. ...
(Date:1/18/2017)... India , January 18, 2017 According to a ... and by Application: Global Opportunity Analysis and Industry Forecast, 2014 - 2022," the ... to reach $1,127 million by 2022, growing at a CAGR of 8.26% from ... in terms of revenue. Continue Reading ... ...
(Date:1/18/2017)...  With an annual growth ranging from 6% to 10%, South East ... International Expo, March 22-24, 2017) serves the industry by fostering the regional discourse - ... Investment Forum ASEAN -- India ... conference content Enhanced business matchmaking program Roadshows ... ...
Breaking Medicine Technology: