Navigation Links
Swelling After Knee Injury May Hinder Healing
Date:8/31/2007

Pig study shows blocking 2 proteins could mean less invasive treatment of meniscus damage

FRIDAY, Aug. 31 (HealthDay News) -- The swelling that normally occurs when a joint is injured may interfere with healing after knee injuries, researchers say.

Publishing in the September issue of Arthritis & Rheumatism, Duke University researchers identified two immune system proteins -- interleuken-1 and tumor necrosis factor -- produced by the body during swelling that blocked the healing of a damaged pig meniscus. The meniscus is a type of cartilage inside the knee joint that acts as a shock absorber between the thigh bone and lower leg bone. Almost 15 percent of all athletic injuries to the knee involve the meniscus. Over time, wear and tear on this cartilage contributes to osteoarthritis.

Medical treatments could be used to block interleuken-1 and tumor necrosis factor and help heal knee injuries and osteoarthritis, the researchers said.

"There already is a drug that blocks the effects of tumor necrosis factor that is used widely and effectively in patients with rheumatoid arthritis, the form of the disease caused by body's own immune system attacking the joint," senior researcher Farshid Guilak said in a prepared statement. "Another drug also exists that blocks IL-1 that is being used for rheumatoid arthritis and is currently undergoing clinical trials for osteoarthritis."

The Duke team exposed pig knees to varying levels of the two proteins. As they increased the dose amount, the meniscus tissue became less able to repair itself. The range of concentrations in the experiment match those found in the joints of humans with rheumatoid arthritis and osteoarthritis.

The majority of meniscus injuries are tears in the tissue. If the tear is small and occurs outside the meniscus, it can be repaired surgically, although surgical repairs are not always effective. A large tear may mean surgeons have to remove the torn tissue entirely, which speeds the progression of osteoarthritis.

These findings, the team said, could result in a targeted, less invasive way to manage meniscus damage.

More information

To learn more about meniscal injuries, visit A Patient's Guide to Meniscal Injuries.



-- Madeline Vann



SOURCE: Duke University, news release, Aug. 30, 2007


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Swelling increases stroke risk with high B.P.
2. Do Not Neglect Your Abdominal Pain/ Swelling - Help Your Doctor In Early Cancer Detection
3. Brain Swelling Key to Reducing Stroke Fatalities
4. Swelling of Prostate Gland Prevented with New drug
5. Surgeon Develops Procedure to Prevent Arm Swelling in Breast Cancer Patients
6. Brain Swelling Halts Conjoined Twin Surgery
7. Thyroid hormone treatment hastens recovery after cardiac surgery
8. Morning after pill effective up to five days after having unprotected sex
9. Liver donors can thrive after transplant
10. Recouping blood flow after a stroke
11. Quality of life after cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/25/2017)... ... April 25, 2017 , ... Back Pain Centers of ... pain with a reputable physician in their area, announces the launch of a new ... for patients who are looking for reputable physicians to help them with back or ...
(Date:4/25/2017)... NJ (PRWEB) , ... April 25, 2017 , ... Saad B. Chaudhary, MD is committed ... treatment of acute or chronic problems, I focus on preventative care with all my patients ... you have any questions, always feel free to contact my office and my trained staff ...
(Date:4/25/2017)... ... 25, 2017 , ... Emergency Physician and Distinguished Professor of Emergency Medicine Bentley ... in Writing, set to publish in summer 2017. , Dr. Bobrow, MD, FACEP, ... Arizona College of Medicine. He also serves as Medical Director for the Bureau of ...
(Date:4/25/2017)... ... April 25, 2017 , ... Vetoquinol ... is introducing Flexadin UCII, part of the EQUISTRO line, at this week’s Rolex ... in horses at the immunologic level. , The scientifically-developed Flexadin UCII supports the ...
(Date:4/24/2017)... ... April 24, 2017 , ... Emmanuel College ... nursing professionals advance their careers. Beginning in the fall of 2017, Emmanuel’s program will ... in as few as 16 months and for as little as $14,528. These changes ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... YORK , April 19, 2017 Global ... drainage devices are tubes used to remove excess liquid ... blood, serum, pus, urine, bile or lymph. Surgical drains ... of surgery such as orthopedics surgery, cardiovascular surgery, neurosurgery, ... is prophylactic post-surgery to prevent accumulation of fluid e.g. ...
(Date:4/19/2017)... Companion animal vaccines ... pets such as canine, avian and feline. ... such as Attenuated Live Vaccines, Conjugate Vaccines, Inactivated ... Recombinant Vaccines. Attenuated live vaccines are derived from ... have been weakend under laboratory conditions. Conjugate vaccines ...
(Date:4/18/2017)... 2017 Cogentix Medical, Inc. (NASDAQ: CGNT), a ... Uro/Gyn and Gynecology markets with innovative and proprietary products, ... March 31, 2017 after the market close on Tuesday, ... host a conference call and webcast to discuss its ... 2017 at 4:30 p.m. Eastern Time (3:30 p.m. Central ...
Breaking Medicine Technology: