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Sweating the small stuff: Early adversity, prior depression linked to high sensitivity to stress
Date:6/28/2011

ey had experienced and what types of life stress they had encountered recently.

The results showed that people who had lost a parent or had been separated from a parent for at least one year before the age of 18 and individuals who had experienced more episodes of depression over their lifetime became depressed following significantly lower levels of recent life stress.

Additional analysis revealed that these effects were unique to stressors involving interpersonal loss.

"Researchers at UCLA and elsewhere have previously demonstrated that early adversity and depression history are associated with heightened sensitivity to stress," Slavich said. "The present study replicates this effect but suggests for the first time that these associations may be unique to stressors involving interpersonal loss. In other words, individuals who are exposed to early parental loss or separation and persons with greater lifetime histories of depression may be selectively sensitized to stressors involving interpersonal loss."

An important question raised by these findings is how adversity early in life and prior experiences with depression promote increased sensitivity to stress. One possibility, the researchers say, is that people who experience early adversity or depression develop negative beliefs about themselves or the world beliefs that get activated in the face of subsequent life stress. Another possibility, which is not mutually exclusive, is that early adversity and depression influence biological systems that are involved in depression, perhaps by lowering the threshold at which depression-relevant processes like inflammation get triggered.

"Although many factors impact stress sensitivity," Slavich said, "thoughts almost always play a role. For example, when your best friend doesn't call back, do you think she is angry at you or do you think it just slipped her mind? Our thoughts affect how we react emotionally and biolog
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Contact: Mark Wheeler
mwheeler@mednet.ucla.edu
310-794-2265
University of California - Los Angeles
Source:Eurekalert

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