Navigation Links
Sweating the small stuff: Early adversity, prior depression linked to high sensitivity to stress
Date:6/28/2011

We all know people who are able to roll with life's punches, while for others, every misfortune is a jab straight to the gut. Research examining this issue has found that although most people require significant adversity to become depressed the death of a loved one, say, or getting fired roughly 30 percent of people with first-time depression and 60 percent of people with a history of depression develop the disorder following relatively minor misfortunes. But no one knew why.

Now, a new study led by UCLA researchers suggests that people become depressed more easily following minor life stress in part because they have experienced early life adversity or prior depressive episodes, both of which may make people more sensitive to later life stress.

George Slavich, an assistant professor at the UCLA Cousins Center for Psychoneuroimmunology, and colleagues assessed individuals' experiences with early adversity, clinical depression and recent life stress. Slavich found that individuals who experienced an early parental loss or separation and people who had more lifetime episodes of depression became depressed following lower levels of life stress than those who didn't have these predisposing factors.

The study appears in the current online edition of the Journal of Psychiatric Research.

"We have known for a long time that some people are more likely to experience mental and physical health problems than others," Slavich said. "For example, while some people get depressed following a relationship breakup, others do not. In this study, we aimed to identify factors that are associated with this phenomenon and to examine whether increased sensitivity to stress might be playing a role."

The researchers recruited 100 individuals with depression, 26 men and 74 women, and interviewed them extensively to determine what types of adversity they were exposed to when they were young, how many episodes of depression they had experienced and what types of life stress they had encountered recently.

The results showed that people who had lost a parent or had been separated from a parent for at least one year before the age of 18 and individuals who had experienced more episodes of depression over their lifetime became depressed following significantly lower levels of recent life stress.

Additional analysis revealed that these effects were unique to stressors involving interpersonal loss.

"Researchers at UCLA and elsewhere have previously demonstrated that early adversity and depression history are associated with heightened sensitivity to stress," Slavich said. "The present study replicates this effect but suggests for the first time that these associations may be unique to stressors involving interpersonal loss. In other words, individuals who are exposed to early parental loss or separation and persons with greater lifetime histories of depression may be selectively sensitized to stressors involving interpersonal loss."

An important question raised by these findings is how adversity early in life and prior experiences with depression promote increased sensitivity to stress. One possibility, the researchers say, is that people who experience early adversity or depression develop negative beliefs about themselves or the world beliefs that get activated in the face of subsequent life stress. Another possibility, which is not mutually exclusive, is that early adversity and depression influence biological systems that are involved in depression, perhaps by lowering the threshold at which depression-relevant processes like inflammation get triggered.

"Although many factors impact stress sensitivity," Slavich said, "thoughts almost always play a role. For example, when your best friend doesn't call back, do you think she is angry at you or do you think it just slipped her mind? Our thoughts affect how we react emotionally and biologically to situations, and these reactions in turn greatly influence our health. Regardless of your prior experiences, then, it is always important to take a step back and make sure you are interpreting situations in an unbiased way, based on the information available."


'/>"/>

Contact: Mark Wheeler
mwheeler@mednet.ucla.edu
310-794-2265
University of California - Los Angeles
Source:Eurekalert

Related medicine news :

1. Genes Play Role in Prognosis With Non-Small Cell Lung Cancers
2. Certain genetic profiles associated with recurrence-free survival for non-small cell lung cancer
3. Small Increase in Diabetes Risk Noted in Statin Patients
4. Small to Mid-Sized Hospitals Turn to Orion Health to Implement Health IT Solutions for Improved Patient Care and Outcomes
5. Media, small businesses invited to ACS Webinar on ways to take advantage of Chinas dynamic growth
6. Small Time Company Rolls into the Big League: Trigger Point Performance Therapy Selected to Attend Athletes' Performance NFL Combine Preparation Program
7. Visual Cues that Improve Walking for People with Movement Disorders - Study Shows Small Change in Arrangement Can Make a Big Difference in Improvement Gained
8. Small Dogs Traced Back to Middle Eastern Wolf
9. Landrieu Comments on Presidents Small Business Health Care Report
10. Small molecule with high impact
11. A Small Grass-roots Non-profit, Announces That They Haven't Gone Away and are Still Alive with Helping the Disadvantaged Children in Ukraine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... ... 24, 2016 , ... A recent article published June 14 on ... article goes on to state that individuals are now more comfortable seeking to undergo ... such as calf and cheek reduction. The Los Angeles area medical group, Beverly Hills ...
(Date:6/24/2016)... ... , ... June 19, 2016 is World Sickle Cell Observance Day. In an ... of holistic treatments, Serenity Recovery Center of Marne, Michigan, has issued a ... Cell Disease (SCD) is a disorder of the red blood cells, which can cause ...
(Date:6/24/2016)... ... June 24, 2016 , ... The ... in Dallas that it will receive two significant new grants to support its ... PHA marked its 25th anniversary by recognizing patients, medical professionals and scientists for ...
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. Amanda Cheng, an ... Dr. Cheng has extensive experience with all areas of orthodontics, including robotic Suresmile ... orthodontics. , Micro-osteoperforation is a revolutionary adjunct to orthodontic treatment. It can ...
(Date:6/24/2016)... ... ... of Topricin and MyPainAway Pain Relief Products, join The ‘Business for a Fair Minimum Wage’ ... 2020 and then adjusting it yearly to increase at the same rate as the median ... floor does not erode again, and make future increases more predictable. , The company is ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 2016 Research and Markets has announced ... Forecast to 2022" report to their offering. ... the patients with kidney failure, it replaces the function of ... patient,s blood and thus the treatment helps to keep the ... balance. Increasing number of ESRD patients & ...
(Date:6/23/2016)... , June 23, 2016 ... "Pharmaceutical Excipients Market by Type (Organic Chemical (Sugar, ... Formulation (Oral, Topical, Coating, Parenteral) - Global Forecast to ... The global pharmaceutical excipients market ... at a CAGR of 6.1% in the forecast period ...
(Date:6/23/2016)... Roche (SIX: RO, ROG; OTCQX: RHHBY) announced ... BRAHMS PCT (procalcitonin) assay as a dedicated testing solution ... this clearance, Roche is the first IVD company in ... sepsis risk assessment and management. PCT is ... levels in blood can aid clinicians in assessing the ...
Breaking Medicine Technology: