Navigation Links
Susan G. Komen awards Case Western Reserve nearly $500,000 to study breast cancer in older women
Date:7/19/2010

CLEVELAND July 19, 2010 Cynthia Owusu, MD, associate professor at Case Western Reserve University and geriatric-oncologist at University Hospitals Case Medical Center, the School's primary affiliate, has received nearly $500,000 from Susan G. Komen For the Cure to fund a novel three-year study aimed at improving outcomes for older women with newly-diagnosed breast cancer.

Recent gains in life expectancy coupled with aging as a risk factor for breast cancer makes breast cancer a disease of older women. While breast cancer mortality rates are declining among women less than 70 years of age, they have either remained stable or increased among the oldest women with breast cancer.

"One reason for the existing age-related disparities in breast cancer mortality is the under-treatment of breast cancer among older women in comparison with their younger counterparts," said Dr. Owusu. "Several barriers have contributed to the under-treatment of older women, such as misconceptions and misinformation about reduced functional reserves and tolerability of cancer treatment by older women. This has served to limit their options and impact their survival."

Dr. Owusu hypothesizes that age-related disparities will be observed in receipt of recommended standard treatment for breast cancer and that age-related disparities in breast cancer treatment will be partly explained by differences in declines in physical function that occur during cancer treatment of older women.

To examine the hypothesis requires measurement of physical function and ensuing decline that occurs during breast cancer treatment of older women. The study will enroll 200 women 65 years of age and over who have been newly diagnosed with stage I-III breast cancer.

"Given that current instruments used by medical oncologists to measure physical function among cancer patients have been shown (by clinical research) not to be particularly accurate when applied to senior adults, and none of the instruments currently recommended for screening in senior adults with cancer have been validated for this purpose, there remains a critical need for a well validated instrument for functional decline among senior adults with cancer," continued Dr. Owusu. "Furthermore, despite the existence of substantial literature supporting a strong correlation between several biomarkers and reduced functional reserves, use of such biomarkers to evaluate risk of functional decline and inform the design of interventions for functional decline among senior adults with cancer, remain unexplored."

As a result, Dr. Owusu has proposed to conduct this longitudinal study of 200 women 65 years of age and older who have been newly diagnosed with stage I-III breast cancer recruited from ambulatory surgical and medical oncology clinics of the University Hospitals Case Medical Center and community satellite facilities, in Cleveland, Ohio. Following enrollment, women will be followed prospectively for 12 months to complete study procedures at several time points as follows: at study entry, post-treatment (primary surgery, chemotherapy and radiation therapy), six months and twelve months (study completion).

As a first step, Dr. Owusu will validate an instrument for identifying functional decline in participating patients and then use the instrument to examine the mediating role of functional decline on age-related disparities in breast cancer treatment.

Results from the study will provide new information on the appropriate instrument for measuring functional decline in older women with breast cancer and on the role of functional decline in age-related disparities in breast cancer treatment.

"Understanding this relation is important for designing strategies for remediation of functional decline," said Dr. Owusu. "The ability to correctly identify reduced functional reserves among older women undergoing treatment for breast cancer should be helpful in ensuring that healthy independent older women go on to receive recommended guideline treatment, and those with reduced functional reserve receive the necessary remediation that optimizes their oncology care. Over the long-term, remediation of functional decline among older women with breast cancer should translate into reductions in treatment differences and improved breast cancer survival."


'/>"/>

Contact: Christina DeAngelis
christina.deangelis@case.edu
216-386-3635
Case Western Reserve University
Source:Eurekalert

Related medicine news :

1. Businesses Rally Big Efforts to Benefit the Susan G. Komen Phoenix Affiliates Fight Against Breast Cancer
2. Hayes Announces Appointment Of Dr Susan Levine To The Medicare Evidence Development and Coverage Advisory Committee (MEDCAC)
3. The American Association on Health and Disability (AAHD) and the Susan G. Komen for the Cure Partner to Increase Accessibility for Women with Disabilities at Mammogram Facilities in the DC Metro Area
4. DC Dermatologist Dr. Susan T. Elliott Selected Best Doctor by Washingtonian Magazine
5. MAYO Communications Retained by MAMMOJAM 2010 Dr. Susan Love Research Foundation Event
6. Highest prize in public health -- the Frank A. Calderone Prize -- to Susan Baker, pioneer
7. Emmy-Award Winning Actress Susan Lucci to Receive Philanthropic Leadership Award at 7th Annual Cure for Sure Dinner
8. Susan Nedza MD, MBA, FACEP Named Vice President, Strategic Clinical Solutions of HealthyCircles
9. Susan G. Komen for the Cure awards grant to Lombardis V. Craig Jordan
10. Susan G. Komen for the Cure and RE/MAX Launch Home for the Cure™
11. Mental Health America Encourages Journalists, Media Professionals to Submit Entries for 2010 Media Awards
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... ... The temporary closing of Bruton Memorial Library on June 21 due to a possible lice ... overlooked aspect of head lice: the parasite’s ability to live away from a human host, ... a necessary one in the event that lice have simply gotten out of control. , ...
(Date:6/25/2016)... ... ... On Friday, June 10, Van Mitchell, Secretary of the Maryland Department of Health and ... their exemplary accomplishments in worksite health promotion. , The Wellness at Work Awards took ... the BWI Marriott in Linthicum Heights. iHire was one of 42 businesses to receive ...
(Date:6/24/2016)... ... June 24, 2016 , ... Marcy was in a crisis. Her son James, eight, was out ... family verbally and physically. , “When something upset him, he couldn’t control his emotions,” remembers ... would throw rocks at my other children and say he was going to kill them. ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway ... call for a minimum wage raise to $12 an hour by 2020 and then adjusting ... restore the lost value of the minimum wage, assure the wage floor does not erode ...
(Date:6/24/2016)... ... 24, 2016 , ... Strategic Capital Partners, LLC (SCP) in ... investment capital for emerging technology companies. SCP has delivered investment events and ... more than a million dollars of capital investment for five companies. ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... , June 27, 2016 Jazz Pharmaceuticals ... waiting period under the Hart-Scott-Rodino Antitrust Improvements Act of ... acquisition of Celator Pharmaceuticals, Inc. ("Celator"; Nasdaq: ... p.m. (Eastern Daylight Time). As previously announced ... into a definitive merger agreement under which Jazz Pharmaceuticals ...
(Date:6/26/2016)... , June 26, 2016 ... care operating models within the health care industry is ... financial efficiency , Deloitte offers a suite of ... business issues impacting efficient cost optimization: labor resource analysis, ... These services facilitate better outcomes and better economics ...
(Date:6/24/2016)... OAKLAND, N.J. , June 24, 2016 /PRNewswire/ ... in the design, development and manufacturing of collagen ... and regeneration announced today that Bill Messer ... Sales and Marketing to further leverage the growing ... surgery medical devices. Bill joins the ...
Breaking Medicine Technology: