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Susan Band Horwitz, Ph.D., receives Eighth Annual AACR Award for Lifetime Achievement in Cancer Research
Date:3/25/2011

s a result, the drug interfered with the normal functions of microtubules during cell division, leading to arrest in mitotis.

These pioneering studies led to clinical trials of the drug in the mid-1980s. Paclitaxel is now involved in first line treatment of many cancers, including ovarian, breast, non-small cell lung cancer, and Kaposi's sarcoma, and as an antiproliferative agent on coronary stents for the prevention of restenosis.

Horwitz' current research focuses on issues surrounding a variety of new natural products that share a similar mechanism to paclitaxel, but also have distinct differences that may enhance their therapeutic value. Her research on paclitaxel resistance has concentrated on p-glycoprotein, mutations in tubulin, modulation of the expression of tubulin isotypes, and more recently overcoming accelerated senescence. In addition, she is also interested in combining paclitaxel with specific inhibitors of signaling pathways to circumvent resistance.

Horwitz has authored more than 250 publications, advancing our knowledge of antitumor drugs and mechanisms of drug resistance. She has received numerous awards including the Cain Memorial Award from the AACR; the ASPET Award for Experimental Therapeutics; the Chester Stock Award from Memorial Sloan-Kettering Cancer Center; the American Cancer Society's Medal of Honor; the Bristol-Myers Squibb Cancer Distinguished Achievement Award; The Barnard Medal of Distinction; and the Warren Alpert Foundation Award from Harvard Medical School. She received a Doctor Honoris Causa, Universit de la Mditerrane, Marseilles, France.

Horwitz served as president of the AACR in 2002-2003. She is a member of the American Academy of Arts and Sciences, National Academy of Sciences and the Institute of Medicine. Horwitz is a fellow of the National Foundation for Cancer Research and The American Society of Pharmacognosy. She was a key figure in the external advisory group that evaluated a
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Contact: Michele Sharp
Michele.Sharp@aacr.org
267-646-0622
American Association for Cancer Research
Source:Eurekalert

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