Navigation Links
Surviving ovarian cancer: Rutgers scientists attack drug resistant cancer cells
Date:12/9/2013

Scientists at Rutgers University have developed a targeted drug delivery system that they believe could make ovarian cancer more treatable and increase survival rates for the most deadly gynecological cancer in the United States.

Tamara Minko, professor in the Ernest Mario School of Pharmacy and Lorna Rodriguez, professor of obstetrics and gynecology at Rutgers Cancer Institute of New Jersey, say because there is not a good screening method for ovarian cancer, most women with the disease are not diagnosed until after it has metastasized to other organs and surgery and chemotherapy are not as effective.

"Once the ovarian cancer becomes drug resistant we cannot cure it," says Rodriguez an oncologist who provides treatment to ovarian cancer patients. "Circumventing the development of drug resistance is a reasonable approach and very much needed."

The main reason for advanced-stage ovarian cancer, they say, is an out of control protein CD44, which enables cancerous tumors to proliferate and become resistant to conventional drug treatments. The result: a five-year survival rate for patients with advanced-stage ovarian cancer that is only 30 percent.

In a new study published in Clinical Cancer Research, Minko and Rodriguez provide results of animal research in which the cancer is attacked at the genetic level by using small, inhibiting RNA molecules that directly target and decrease the excess CD44 protein in cancer cells while simultaneously treating patients with the anti-cancer drug paclitaxel. This allows cells within the cancerous tumors to be successfully treated even at an advanced stage.

"We expect that the proposed treatment will be especially effective in advanced stages of ovarian cancers, where there are many cancer stem cells in the tumors that resist conventional drug treatment," says Minko.

In their research, scientists at Rutgers created animal models that closely resemble the cancerous tumors found in women w
'/>"/>

Contact: Robin Lally
rlally@ucm.rutgers.edu
732-932-7084 x652
Rutgers University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Former Athlete Credits Sports for Surviving Horrible Car Accident and Lengthy Coma
2. Stage I NSCLC patients who receive radiation therapy are surviving longer
3. Floodmasters 5 Tips to Surviving the Next Hurricane Sandy
4. Too Much Sitting May Lower Odds of Surviving Colon Cancer
5. More Infants Surviving With Serious Heart Defects, Study Finds
6. ParentMagic Inc Releases Enhanced E-Book “Surviving Your Adolescents” Available in iBooks on iOS
7. Study Finds Overweight Young Males Have a Greater Risk of Not Surviving Until Age 55, Making Weight Loss Supplements Like Prescopodene Helpful With Increasing Longevity
8. Surviving a Tornado and Then Facing Homeowner Insurance Battles
9. Parent Magic Inc's "Surviving Your Adolescents" Wins Gold Award in National Parenting Publications Awards 2013
10. Taller, Heavier Women May Face Higher Ovarian Cancer Risk
11. U.S. Panel Rejects Ovarian Cancer Screening
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... 2014 Ticket Down is a reliable ... NYC. In just a week, the U.S. Open Tennis Championship ... The event was originally founded in 1881 and features grass courts ... forced to withdrawal from the event because of a wrist injury. ... will return to New York City with hopes of winning her ...
(Date:8/20/2014)... HealthDay Reporter WEDNESDAY, Aug. ... dramatically during the past two decades, plummeting 57 percent and ... An estimated 4 million fewer births occurred among teenagers ... the U.S. Centers for Disease Control and Prevention. That ... report," said Bill Albert, chief program officer of The National ...
(Date:8/20/2014)... examined patient and tumor characteristics for melanomas with ... growth) in an effort to increase earlier detection ... , Author: Sarah Shen, M.B.B.S., B.Med.Sci., of ... Background: The tumor characteristic known as mitotic ... with prognosis and survival in melanoma patients. However, ...
(Date:8/20/2014)... discovered that the immune system is defective in people suffering ... sufferers have ongoing issues with pain. , The research ... also help to explain why some painkillers may not offer ... up to 10% of the community. There are different ... pain, which often has the greatest impact on sufferers, quality ...
(Date:8/20/2014)... now, Free content, The time to deploy Ebola ... published early online today in Annals of ... of Public Health write that the relentless epidemiologic trajectory ... a public health crisis that shows no signs of ... developed in the last decade, yet the sporadic nature ...
Breaking Medicine News(10 mins):Health News:2014 U.S. Open Tennis Tickets: Ticket Down Slashes Ticket Prices on All US Open Tennis Championship Sessions in New York at Arthur Ashe Stadium 2Health News:2014 U.S. Open Tennis Tickets: Ticket Down Slashes Ticket Prices on All US Open Tennis Championship Sessions in New York at Arthur Ashe Stadium 3Health News:2014 U.S. Open Tennis Tickets: Ticket Down Slashes Ticket Prices on All US Open Tennis Championship Sessions in New York at Arthur Ashe Stadium 4Health News:2014 U.S. Open Tennis Tickets: Ticket Down Slashes Ticket Prices on All US Open Tennis Championship Sessions in New York at Arthur Ashe Stadium 5Health News:Teen Birth Rate Has Dropped Dramatically in Last Two Decades: CDC 2Health News:Teen Birth Rate Has Dropped Dramatically in Last Two Decades: CDC 3Health News:Patient, tumor characteristics for high-mitotic rate melanoma 2Health News:Pain treatments less effective for those with irritable bowel 2Health News:News from Annals of Internal Medicine 2
... say that they have developed a faster, less expensive ... stretches of DNA. The development of the new technique ... mutant genes, but also from mutations of other DNA ... occur as a consequence of deleting non-gene DNA sequences, ...
... is an eye disease that can cause blindness and ... get past the blood-brain barrier making it an ... an engineering professor with appointments in UCFs Advanced Materials ... ,Seal and his colleagues from North Dakota ...
... suggests that playing with candy cigarettes may favorably set ... smokers . , The study, reported in ... a nationally representative sample of 25,887 US adults, the ... in current and former smokers vs. 22% in never ...
... Kingdom have found that patients with COPD, or chronic ... researchers also found that those COPD patients with osteoporosis, ... greater arterial stiffness. These premature signs of aging may ... cardiovascular disease. ,Their research results appear in ...
... Cancer Center researchers helps explain how memory T cells ... shows lymph nodes are not just organs where immune ... where a major fight against the spread of an ... many viruses, the body becomes immune (protected) from recurrence ...
... pair and played hide-and-seek Monday evening in a relatively rare ... ,As the cloud blanket gave way to an ... fields, parks and from top of their houses - had ... of the Nehru Planetarium here, assisted by over a dozen ...
Cached Medicine News:Health News:Boffins Develop New Technique to Hunt Illness-causing Mutants in Non-gene DNA 2Health News:Nanoparticle in the Treatment of Glaucoma 2Health News:The Danger in Candy Cigarettes 2Health News:Premature Vascular and Bone Changes Occur in COPD Patients 2Health News:Premature Vascular and Bone Changes Occur in COPD Patients 3Health News:Memory T Cells Protect the Body from Viruses 2
(Date:8/20/2014)... Aug. 20, 2014 Reportlinker.com announces ... available in its catalogue: Personal ... Trends and Opportunities to 2018 ... The report provides in depth market analysis, ... accident and health insurance segment, including: - ...
(Date:8/20/2014)... Calif. , Aug. 20, 2014 ... will be using advanced, ventilator technology from Covidien ... to care for patients. The ... more naturally, compared to conventional mechanical ventilation, and ... soon as possible. Patients on mechanical ventilation are ...
(Date:8/20/2014)... DUBLIN , Aug. 20, 2014 ... addition of the "Global Biosimilars/Follow-on-Biologics Market (Technology, ... 2013 - 2020" report to their offering. ... biosimilars/follow-on-biologics market (types, applications and geography) - Size, ... Research, Report, Opportunities, Segmentation and Forecast, 2013 - ...
Breaking Medicine Technology:Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 2Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 3Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 4Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 5Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 6Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 7Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 8Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 9Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 10Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 11Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 12Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 13Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 14Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 15Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 16Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 17Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 18Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 19Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 20Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 21Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 22Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 23Torrance Memorial Medical Center Acquires Advanced Ventilator Technology to Enhance Patient Care 2Global Biosimilars/Follow-on-Biologics Market (Technology, Types, Applications, Services and Geography) - Research Report, 2013 - 2020 2
... into blood-related diseases saves and improves the lives of millions ... this fact means that too often, funding does not feed ... "Haematology is probably the area of medicine that has progressed ... "La Sapienza" University of Rome. "For example, acute lymphoblastic leukaemia ...
... Unilife Corporation ("Unilife" or the "Company") (NASDAQ: ... Officer, Dr. Ramin Mojdeh, will purchase more than $250,000 in ... Dr. Mojdeh,s initial open market purchase of more than $250,000 ... joined the Company. Dr. Mojdeh will begin making ...
Cached Medicine Technology:Better Funding for Research into Blood Diseases Will Save More Lives 2Unilife COO to Again Purchase More Than $250,000 in Company Shares 2Unilife COO to Again Purchase More Than $250,000 in Company Shares 3
For primary and revision cases...
The Protract stem offers a press-fit option which will allow choice of standard or lateralized neck offsets while keeping a consistent leg length....
Standard Erlanger hip stem....
Cemented foundation 460 series....
Medicine Products: