Navigation Links
Survival shortened when ER/PR negative breast cancer spreads to the brain
Date:12/17/2007

me from:

  • Diagnosis to distant metastasis was a median of 15 months in the triple negative group versus 24 months in the rest of the patients.
  • Distant metastasis to brain metastasis was a median of three months for triple negative cancer versus 11 months for other subtypes.
  • Brain metastasis to death, on average, was the same in both groups seven months presumably because the tumors, once in the brain, were treated alike, with whole brain radiation, stereotactic radiosurgery, and /or surgery, despite their tumor subtype.
  • Diagnosis to death was a median of 26 months in the triple negative patients versus 49 months in other patients.

Dr. Vallow and her team of researchers looked at data from 83 women whose HER2+ tumors had spread to their brains. They found that:

  • Patients with ER/PR- tumors were more likely to have brain metastasis as the first site of disease progression (73 percent) compared to women with ER/PR+ cancer (27 percent).
  • Time from diagnosis to brain metastasis was a median of 45 months in ER/PR+ tumors compared to 14.5 months in ER/PR- cancer.
  • Time from brain metastasis to death was a median 10 months in women with ER/PR+ tumors compared to 3 months in patients with ER/PR- cancer.
  • Median survival for the ER/PR+ patients was 55 months compared with 17.5 months in patients with ER/PR- cancer.

This study shows us that the outcome of HER2 patients with brain metastasis tended to be worse for those women with ER/PR negative status, however, because this study was small, more patients need to be studied to confirm this finding, Dr. Vallow says.


'/>"/>

Contact: Paul Scotti
scotti.paul@mayo.edu
904-953-2299
Mayo Clinic
Source:Eurekalert

3

GOOD

Page: 1 2 3

Related medicine news :

1. Conventional prognostic factors fail to explain better prostate cancer survival in most Asian men
2. Survival differences by race most apparent in advanced stages of breast cancer
3. Prophylactic cranial irradiation in small cell lung cancer significantly increases survival
4. Human C-reactive protein regulates myeloma tumor cell growth and survival
5. Mediterranean Diet May Boost Alzheimers Survival
6. Hospitals Improve Survival Rates While Treating Sicker Patients Thomson Healthcare Study Shows
7. The Fight for His Life: Author, Family Battle Disease and Challenge Politics in the Face of Survival
8. Communication in cancer world is key to survival
9. Molecular profiling can accurately predict survival in colon cancer patients
10. New chemotherapy regimen prolongs survival in difficult-to-treat childhood brainstem gliomas
11. Phase II study shows HRPC patients with bone metastases see improved survival with ZD4054
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/18/2010)... Taxes, Other Tobacco Prevention Initiatives , ... , , ... ... ... WASHINGTON , March 18 Kids in New Jersey will take center stage in the fight against tobacco on March ...
(Date:3/18/2010)... ... , , ... ... ... New Hampshire will take center stage in the fight against tobacco on March 24 as they join thousands of young people nationwide ...
(Date:3/18/2010)... President and CEO, Legacy(SM) , ... , , ... ... WASHINGTON , March ... ...
(Date:3/18/2010)... of U.S. medical students choosing internal medicine residencies ... significantly impact the shortage of primary care physicians. ... Program report, 2,722 U.S. seniors at medical schools ... 3.4 percent increase from 2,632 in 2009. The ... (2,660), 2007 (2,680), and 2006 (2,668). In comparison, ...
(Date:3/18/2010)... In its 21-year history, under the ... leaders, SRLA has trained more than 40,000 teenagers from ... area to complete the 26.2 mile Los Angeles Marathon. ... volunteer leaders will again participate in the LA Marathon. ... SRLA,s mission is to challenge at-risk secondary students to ...
Breaking Medicine News(10 mins):Health News:New Jersey Kids 'Kick Butts' on March 24 2Health News:New Jersey Kids 'Kick Butts' on March 24 3Health News:New Jersey Kids 'Kick Butts' on March 24 4Health News:New Jersey Kids 'Kick Butts' on March 24 5Health News:New Hampshire Kids 'Kick Butts' on March 24 2Health News:New Hampshire Kids 'Kick Butts' on March 24 3Health News:New Hampshire Kids 'Kick Butts' on March 24 4Health News:Food and Drug Administration Issues Final Rule Regarding Sale, Distribution, and Use of Cigarettes and Smokeless Tobacco 2Health News:Food and Drug Administration Issues Final Rule Regarding Sale, Distribution, and Use of Cigarettes and Smokeless Tobacco 3Health News:Food and Drug Administration Issues Final Rule Regarding Sale, Distribution, and Use of Cigarettes and Smokeless Tobacco 4Health News:Food and Drug Administration Issues Final Rule Regarding Sale, Distribution, and Use of Cigarettes and Smokeless Tobacco 5Health News:Residency match results not encouraging for adults needing primary care 2Health News:Students Run LA Takes 40,000 Students Across the Marathon Finish Line Over Past 21 Years 2Health News:Students Run LA Takes 40,000 Students Across the Marathon Finish Line Over Past 21 Years 3
... French . , Montreal, April 14 2009 ... rule seems to apply to most diseases except HIV-AIDS, which ... called "CD4+" cells have disappeared. The results of a North ... of the Research Institute of the MUHC, run contrary to ...
... offer added flavors, antioxidants and nutritional benefits; Packaging now ... new wave of excitement to the enhanced water category, ... a low-calorie, nutrient enhanced water beverage designed to help ... 10 calories per serving(1), Propel is available ...
... Warns of Effects From Bleeding to Drug Interactions NEW ... or "herbal" are virtually synonymous with safety and purity. ... mistakenly believed to be free of significant risks. A ... warns that more than 40% of plastic surgery patients ...
... SAN FRANCISCO, April 14 Deloitte today released a ... of follow-on biologics, that explores the debate on ... biologics (FOBs), drugs that are envisioned as the biotech ... that have recently been introduced in Congress, both based ...
... guide to showcase Malaysia,s world-class medical facilities , ... ... of Private Hospitals of Malaysia (APHM) jointly announce the launch of ... for international distribution. The Malaysia Edition will be formally launched on ...
... sole marketing exclusivityPITTSBURGH, April 14 Mylan Inc. (Nasdaq: ... and its subsidiary Mylan Pharmaceuticals Inc. have been sued ... of an Abbreviated New Drug Application (ANDA) with the ... 150 mg and 500 mg, the generic version of ...
Other Medicine News:Health News:Treating HIV earlier to decrease the risk of death 2Health News:Propel Unveils New Enhanced Experience 2Health News:Propel Unveils New Enhanced Experience 3Health News:Are Herbal Supplements Putting Aesthetic Surgery Patients at Risk? 2Health News:Are Herbal Supplements Putting Aesthetic Surgery Patients at Risk? 3Health News:Are Herbal Supplements Putting Aesthetic Surgery Patients at Risk? 4Health News:Avoiding No Man's Land: New Deloitte Study on Follow-on Biologics Investigates Proposed Legislation and Possible Unintended Consequences 2Health News:Avoiding No Man's Land: New Deloitte Study on Follow-on Biologics Investigates Proposed Legislation and Possible Unintended Consequences 3Health News:Avoiding No Man's Land: New Deloitte Study on Follow-on Biologics Investigates Proposed Legislation and Possible Unintended Consequences 4Health News:Patients Beyond Borders Malaysia Edition to Launch in July 2Health News:Patients Beyond Borders Malaysia Edition to Launch in July 3Health News:Mylan Confirms First-to-File Patent Challenge Relating to Xeloda(R) Cancer Treatment 2
(Date:3/18/2010)... March 18 Poniard Pharmaceuticals, Inc. ... innovative oncology therapies, today announced that the U.S. Patent ... the composition of matter patent for picoplatin as RE41209, ... 2010 . The reissue was applied for May ... , the USPTO released the "Issue Notification" for the ...
(Date:3/18/2010)... , March 18 ... Chief Executive Officer, Pfizer, was elected board ... of America (PhRMA) today at the trade ... Chief Executive Officer Christopher Viehbacher ... Directors, and John C. Lechleiter , ...
(Date:3/18/2010)... results in too much ammonia in the blood. , ... , , ... ... (Logo: ... ...
Breaking Medicine Technology:U.S. Patent and Trademark Office Grants Reissue Patent on Picoplatin Composition of Matter 2U.S. Patent and Trademark Office Grants Reissue Patent on Picoplatin Composition of Matter 3U.S. Patent and Trademark Office Grants Reissue Patent on Picoplatin Composition of Matter 4U.S. Patent and Trademark Office Grants Reissue Patent on Picoplatin Composition of Matter 5Pfizer's Jeffrey Kindler Becomes PhRMA Board Chairman; Christopher Viehbacher, John Lechleiter Assume New Posts 2Pfizer's Jeffrey Kindler Becomes PhRMA Board Chairman; Christopher Viehbacher, John Lechleiter Assume New Posts 3Pfizer's Jeffrey Kindler Becomes PhRMA Board Chairman; Christopher Viehbacher, John Lechleiter Assume New Posts 4Pfizer's Jeffrey Kindler Becomes PhRMA Board Chairman; Christopher Viehbacher, John Lechleiter Assume New Posts 5Pfizer's Jeffrey Kindler Becomes PhRMA Board Chairman; Christopher Viehbacher, John Lechleiter Assume New Posts 6Pfizer's Jeffrey Kindler Becomes PhRMA Board Chairman; Christopher Viehbacher, John Lechleiter Assume New Posts 7Pfizer's Jeffrey Kindler Becomes PhRMA Board Chairman; Christopher Viehbacher, John Lechleiter Assume New Posts 8FDA Approves Drug to Treat Condition That Causes Elevated Ammonia Levels 2FDA Approves Drug to Treat Condition That Causes Elevated Ammonia Levels 3FDA Approves Drug to Treat Condition That Causes Elevated Ammonia Levels 4FDA Approves Drug to Treat Condition That Causes Elevated Ammonia Levels 5Johns Hopkins researchers track down protein responsible for chronic rhinosinusitis with polyps 61897 1Johns Hopkins researchers track down protein responsible for chronic rhinosinusitis with polyps 61897 2Johns Hopkins researchers track down protein responsible for chronic rhinosinusitis with polyps 61897 3Exposure to lead tobacco smoke raises risk of ADHD 10856 1Exposure to lead tobacco smoke raises risk of ADHD 10856 2Measuring and modeling blood flow in malaria 61892 1Measuring and modeling blood flow in malaria 61892 2
... Findings Reported Safety & Tolerability Profile,in Subjects ... --, CHICAGO, June 25, 2007 /PRNewswire-FirstCall/ -- ... annual meeting of the American Diabetes,Association demonstrated ... development by Bristol-Myers,Squibb Company and AstraZeneca , ...
... Unique Mechanism of Action and Broad Potential ... Calif., June 26, 2007 (PRIME NEWSWIRE) -- ... the treatment of neurological conditions, announced today ... an article,featuring Avigen's pipeline product, AV411 (ibudilast), ...
Other Medicine Technology:Data Demonstrated Saxagliptin Added to Metformin Improved Glycemic,Control in Subjects with Type 2 Diabetes Compared to Metformin,Alone 2Data Demonstrated Saxagliptin Added to Metformin Improved Glycemic,Control in Subjects with Type 2 Diabetes Compared to Metformin,Alone 3Data Demonstrated Saxagliptin Added to Metformin Improved Glycemic,Control in Subjects with Type 2 Diabetes Compared to Metformin,Alone 4Data Demonstrated Saxagliptin Added to Metformin Improved Glycemic,Control in Subjects with Type 2 Diabetes Compared to Metformin,Alone 5Data Demonstrated Saxagliptin Added to Metformin Improved Glycemic,Control in Subjects with Type 2 Diabetes Compared to Metformin,Alone 6Expert Opinion Highlights Avigen's AV411 as Potential New,Therapeutic for Neuropathic Pain and Opioid Withdrawal 2Expert Opinion Highlights Avigen's AV411 as Potential New,Therapeutic for Neuropathic Pain and Opioid Withdrawal 3Expert Opinion Highlights Avigen's AV411 as Potential New,Therapeutic for Neuropathic Pain and Opioid Withdrawal 4Expert Opinion Highlights Avigen's AV411 as Potential New,Therapeutic for Neuropathic Pain and Opioid Withdrawal 5
The Natural Selection family of specialty allografts are spinal allograft devices to eliminate the need for painful autograft harvesting....
... VG2 PLIF Allograft is comprised ... surrounding a cancellous center. The cortical ... support. The cancellous bone provides a ... osteoconductive environment. Superior and inferior surface ...
Williams Micro Discectomy Instruments are designed to be used in the microsurgical treatment of herniated disks....
Meyerding Laminectomy Retractors, self-retaining....
Medicine Products: