Navigation Links
Survival in metastatic breast cancer directly linked to circulating tumor cells

Brussels, 6 May 2010 -- A new study of metastatic breast cancer shows that the number of circulating tumor cells patients have in their blood directly correlates with the length of their survival. Reported at the IMPAKT Breast Cancer Conference in Brussels, Belgium, the results have the potential to improve the delivery of personalized therapy to these patients.

Circulating tumor cells --cancer cells found in a patient's bloodstream-- are detected in 50% to 80% of patients with metastatic breast cancer. Since 2004, doctors have known that patients with 5 or more of these cells in 7.5 ml of blood survive on average for less time than those with fewer than 5 cells.

Dr Antonio Giordano from MD Anderson Cancer Center in Houston, USA, and colleagues set out to refine this prognostic test using a sophisticated computer model known as an artificial neural network.

"We chose to use an artificial neural network model to analyze 516 consecutive metastatic breast cancer patients at the University of Texas MD Anderson Cancer Center because, unlike more typical statistical methods, it can estimate the complex interactions between different factors over time," said Dr Giordano. "Our model, designed at the University of Naples Federico II, simply represents a dynamic time-related analysis of survival, taking into account all prognostic factor correlations."

Using the artificial neural network, the researchers studied the relationship between increasing numbers of circulating tumor cells and survival for different subgroups of breast cancer.

"We found that there was a linear relationship between the number of circulating tumor cells and the risk of death in patients with metastatic breast cancer. Most importantly, the risk of death after 1 year for patients with 40 circulating tumor cells in 7.5 ml of blood was about twice that for patients with none."

"These results show that the simple cutoff number of 5 circulating tumor cells probably does not adequately represent the complexity of this prognostic variable," Dr Giordano said. "Artificial neural networks are sophisticated techniques for analyzing survival of patients according to continuous variables over time."

Translated to clinical practice, these results suggest that monitoring of circulating tumor cell numbers should now be considered a standard test for patients with metastatic breast cancer, Dr Giordano said.

"While the treatment of this condition remains palliative, monitoring of circulating tumor cells can help determine when to modify regimens or discontinue therapy, in other words, this can improve the delivery of personalized therapy."


Contact: Vanessa Pavinato
European Society for Medical Oncology

Related medicine news :

1. One Sigmoidoscopy Boosts Colon Cancer Survival Odds
2. Youngest Preemies Survival Rate Unchanged
3. Researchers Boost Post-Heart Attack Survival in Mice
4. Beta-blockers help reduce metastasis and improve survival in breast cancer patients
5. Survival in metastatic breast cancer patients is improving: targeted therapies have contributed
6. Pregnancy for breast cancer survivors: Meta-analysis reveals it is safe and could improve survival
7. Accepting Help Improves Survival Among Diabetics
8. New therapies increase survival rates in post-transplant liver cancer patients
9. Chemo May Boost Survival After Lung Cancer Surgery
10. Recurrence of breast cancer after more than 10 years is an important indicator of survival
11. Mammograms May Not Boost Survival, Danish Study Suggests
Post Your Comments:
(Date:11/30/2015)... MN (PRWEB) , ... November 30, 2015 , ... ... at . The directory is specialized and only includes chiropractic clinics ... to find a competent and trustworthy alternative health practitioner when back pain sets ...
(Date:11/30/2015)... ... November 30, 2015 , ... In an effort ... the Word of Life Christian Church of Flint, MI, hosted a family-oriented evening ... 1.25 ton pile of candy dubbed “Candy Mountain”. , A Forever Recovery, a ...
(Date:11/30/2015)... ... November 30, 2015 , ... During ... fundraising campaign to raise funds for its research, education, support, and advocacy efforts. ... organization’s annual funding. , The Mesothelioma Applied Research Foundation, which also goes by ...
(Date:11/30/2015)... Dallas, TX (PRWEB) , ... November 30, 2015 ... ... its primary Catalyst continuing education course in Dallas, TX, on January 29 and ... are looking to improve the functions of their practices, to learn how to ...
(Date:11/30/2015)... , ... November 30, 2015 , ... ... chart and ingredient list of its hemorrhoid ointment to its website. , “Our ... relief for people suffering from hemorrhoids. Adding the comparison chart and ingredient list ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... and ST. LOUIS , Nov. ... (NASDAQ: ESRX ) today announced an early renewal ... which began in 1999, will now extend through at ... --> After evaluating pharmacy benefit manager capabilities during ... Express Scripts continues to offer the best health plan ...
(Date:11/30/2015)... Nov. 30, 2015 iCAD, Inc. (Nasdaq: ... feature its latest solutions for advanced image analysis ... cancer at the Radiological Society of North American ... from November 29 to December 4, ... including iReveal®, an automated breast density assessment solution, ...
(Date:11/30/2015)... 30, 2015 NHS Supply Chain has ... machines from Varian Medical Systems (NYSE: VAR ... replace older machines and institute modern radiotherapy and ... hospitals. The order, placed in September, also includes ... Varian,s RapidArc® and Eclipse™ software systems.    ...
Breaking Medicine Technology: