Navigation Links
Survival difference are not black and white
Date:12/6/2011

Highlights

  • Among patients on dialysis, African Americans tend to live longer than whites
  • This survival difference only exists among patients with high levels of inflammation
  • Determining inflammation's role may improve survival for all patients treated with dialysis

Washington, DC In the general population, African Americans die at earlier ages than whites, but among patients on dialysis, African Americans live longer than whites. A new study helps explain this paradox and could help prolong the lives of all patients on dialysis. The study appears in the Journal of the American Society Nephrology (JASN), a publication of the American Society of Nephrology.

High levels of inflammationwhich may be due to conditions such as infections, inflammatory illnesses, periodontal disease, chronic lung disease, and obesityincrease dialysis patients' risk of dying prematurely. Deidra Crews, MD (Johns Hopkins University) and her colleagues wondered whether racial differences in inflammation might explain the survival paradox among dialysis patients.

The investigators followed 554 white and 262 African American dialysis patients from 81 clinics for an average of three years (range four months to 9.5 years). Among the major findings:

  • At five years, a lower percentage of African Americans (34%) died compared with whites (56%), as expected.
  • A survival advantage for African Americans only existed among patients with high levels of inflammation.
  • When comparing patients with lower levels of inflammation, African American and white patients survived for similar lengths of time.

What is it about inflammation that could lead to these findings? It's not clear yet, but the authors note that inflammation in whites may be caused mostly by heart disease, while in African Americans it may be due to other causes that have less detrimental effects on survival. (At the start of dialysis, half of whites in the study had heart disease compared with a third of African Americans.) Alternatively, African Americans and whites may simply respond differently to inflammation, which implies that some genetic trait allows African Americans to "handle" it better than whites.

"Our findings challenge the long held notion that African Americans do better than whites on dialysis. If we can determine, and somehow modify the impact of inflammation, we may be able to improve survival for all patients treated with dialysis," said Dr. Crews.


'/>"/>
Contact: Adrienne Lea
alea@asn-online.org
202-503-6560
American Society of Nephrology
Source:Eurekalert

Related medicine news :

1. Paxil Blocks Tamoxifen, Lowers Survival Odds Against Breast Cancer
2. Certain genetic profiles associated with recurrence-free survival for non-small cell lung cancer
3. Survival benefit with high-intensity end-of-life approaches
4. Aspirin May Boost Breast Cancer Survival
5. Research validates surgery alone offers reasonable overall survival for stage I SCLC
6. News brief: ALDH associated with worse overall survival in patients with pancreatic adenocarcinoma
7. Drug Improved Survival in Mice With Cystic Fibrosis
8. Combined drug therapy to treat TB and HIV significantly improves survival
9. Pre-Diagnosis Diet Linked to Ovarian Cancer Survival
10. Poniard Pharmaceuticals Presents Positive Survival Data from a Phase 2 Clinical Study of Picoplatin in Metastatic Prostate Cancer at the 2010 American Society of Clinical Oncology Genitourinary Cancers Symposium
11. Recent Earthquakes Across the World Underscore the Importance of Emergency Preparedness Supplies and Survival Kits for Individuals, Families and Businesses
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/31/2016)... ... May 31, 2016 , ... The Global Wellness ... released ten predictions on the future of wellness, travel, spa and beauty in Europe. ... spa and beauty companies to leading economists and researchers - to forecast where wellness ...
(Date:5/31/2016)... ... May 31, 2016 , ... ... numeral energies can describe personality traits in humans. Using presidential candidate Donald Trump ... name and vitality. , “AstroNumerology is not about adding numbers up,” says ...
(Date:5/31/2016)... IL (PRWEB) , ... May 31, 2016 , ... The ... and executive committee members: , David G. Lewallen, MD, began his term as ... past president. Michael L. Parks, MD, is OREF’s new president-elect. Richard F. Kyle, MD, ...
(Date:5/31/2016)... ... May 31, 2016 , ... Phynd Technologies, Inc. announced recently the signing of ... TX and Shore Medical Center – Somers Point, NJ. The new clients range in ... demonstrating the breadth of Phynd’s solution and its interoperability. , Houston Methodist is a ...
(Date:5/31/2016)... ... May 31, 2016 , ... In a recent interview on The Greenburgh ... New Rochelle, NY-based WVOX (1460 AM), leading medical insurance advocate Adria Goldman ... country’s “modern medical money maelstrom.” , During the interview with Mr. Feiner that ...
Breaking Medicine News(10 mins):
(Date:5/27/2016)... highlights the necessity of health literacy within the technology advancement of diagnostic imaging. According to ... a majority of oncology patients undergo imaging screenings without understanding the nuanced risks associated ... ... ... Medical Diagnostic Imaging Ampronix ...
(Date:5/27/2016)... May 27, 2016 Hutchison ... company focused on the highly lucrative global oncology ... pipeline of potential first-in-class or best-in-class tyrosine kinase ... development with strategic partners. HCM,s profitable Chinese healthcare ... market. We expect progress of the mid-to-late-stage pipeline ...
(Date:5/27/2016)... NEW YORK , May 27, 2016 ... with biotechs, drug manufacturers, health insurance companies all falling ... very small healthcare companies. While not often talked about, ... The United States is by ... the world. Advanced Medical Isotope Corp. (OTC: ADMD), Nutranomics ...
Breaking Medicine Technology: