Navigation Links
Survival difference are not black and white
Date:12/6/2011

Highlights

  • Among patients on dialysis, African Americans tend to live longer than whites
  • This survival difference only exists among patients with high levels of inflammation
  • Determining inflammation's role may improve survival for all patients treated with dialysis

Washington, DC In the general population, African Americans die at earlier ages than whites, but among patients on dialysis, African Americans live longer than whites. A new study helps explain this paradox and could help prolong the lives of all patients on dialysis. The study appears in the Journal of the American Society Nephrology (JASN), a publication of the American Society of Nephrology.

High levels of inflammationwhich may be due to conditions such as infections, inflammatory illnesses, periodontal disease, chronic lung disease, and obesityincrease dialysis patients' risk of dying prematurely. Deidra Crews, MD (Johns Hopkins University) and her colleagues wondered whether racial differences in inflammation might explain the survival paradox among dialysis patients.

The investigators followed 554 white and 262 African American dialysis patients from 81 clinics for an average of three years (range four months to 9.5 years). Among the major findings:

  • At five years, a lower percentage of African Americans (34%) died compared with whites (56%), as expected.
  • A survival advantage for African Americans only existed among patients with high levels of inflammation.
  • When comparing patients with lower levels of inflammation, African American and white patients survived for similar lengths of time.

What is it about inflammation that could lead to these findings? It's not clear yet, but the authors note that inflammation in whites may be caused mostly by heart disease, while in African Americans it may be due to other causes that have less detrimental effects on survival. (At the start of dialysis, half of whites in the study had heart disease compared with a third of African Americans.) Alternatively, African Americans and whites may simply respond differently to inflammation, which implies that some genetic trait allows African Americans to "handle" it better than whites.

"Our findings challenge the long held notion that African Americans do better than whites on dialysis. If we can determine, and somehow modify the impact of inflammation, we may be able to improve survival for all patients treated with dialysis," said Dr. Crews.


'/>"/>
Contact: Adrienne Lea
alea@asn-online.org
202-503-6560
American Society of Nephrology
Source:Eurekalert

Related medicine news :

1. Paxil Blocks Tamoxifen, Lowers Survival Odds Against Breast Cancer
2. Certain genetic profiles associated with recurrence-free survival for non-small cell lung cancer
3. Survival benefit with high-intensity end-of-life approaches
4. Aspirin May Boost Breast Cancer Survival
5. Research validates surgery alone offers reasonable overall survival for stage I SCLC
6. News brief: ALDH associated with worse overall survival in patients with pancreatic adenocarcinoma
7. Drug Improved Survival in Mice With Cystic Fibrosis
8. Combined drug therapy to treat TB and HIV significantly improves survival
9. Pre-Diagnosis Diet Linked to Ovarian Cancer Survival
10. Poniard Pharmaceuticals Presents Positive Survival Data from a Phase 2 Clinical Study of Picoplatin in Metastatic Prostate Cancer at the 2010 American Society of Clinical Oncology Genitourinary Cancers Symposium
11. Recent Earthquakes Across the World Underscore the Importance of Emergency Preparedness Supplies and Survival Kits for Individuals, Families and Businesses
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... As health professionals work to improve their ... The patient is doing more than filling out a survey; in many cases health ... increasing emphasis in health care and research on the importance of active engagement with ...
(Date:10/13/2017)... ... , ... The American Board of Family Medicine's (ABFM) Board of Directors has ... succeeding Dr. James C. Puffer upon his retirement. Dr. Newton will serve in the ... at the end of 2018. Upon assuming the role of President and CEO on ...
(Date:10/13/2017)... ... October 13, 2017 , ... PurhealthRX , a leading Health and ... Applying the Purzorb™process to full spectrum CBD oil will revolutionize the rapidly growing CBD ... that can be easily incorporated into liquid products, while reducing costs to end users. ...
(Date:10/13/2017)... ... October 13, 2017 , ... Lori R. Somekh, founder of ... ElderCounsel, a national organization of elder law and special needs planning attorneys. “Membership in ... It also provides a forum to network with elder law attorneys nationwide,” said Somekh. ...
(Date:10/13/2017)... SAN LUIS OBISPO, Calif. (PRWEB) , ... October 13, 2017 , ... ... with Alzheimer’s or dementia. However, many long-term care insurance companies have a waiver for ... mean is the 90-day elimination period, when the family pays for care, is often ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... 11, 2017  BioPharmX Corporation (NYSE MKT: BPMX) researchers ... an innovative way to use nonlinear optical imaging to ... new drugs. ... will show how researchers from BioPharmX and the Wellman ... used a suite of imaging techniques in what is ...
(Date:10/10/2017)...  NDS received FDA 510(k) clearance in May 2017 for its ... specifically designed for endoscopy environments. An innovative secondary monitor solution, ZeroWire ... to support the improvement of patient outcomes, procedural efficiency, and the ... ... ...
(Date:10/4/2017)... , Oct. 4, 2017  South Korean-based healthcare product ... training aide "cprCUBE" on Kickstarter. The device will educate ... cardiac arrests with better efficiency compared to the dated ... real-time feedback on efficacy of the compression for a ... has a goal to raise $5,000. ...
Breaking Medicine Technology: