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Surveyed Oncologists Indicate that Avastin has Advantages over Temodar/Temodal in Increasing Overall Survival of High-Grade Glioma
Date:3/9/2009

A Drug That Improves Survival, When Added to Temodar/Temodal, Would Earn a 65 Percent Patient Share in the U.S. and a 30 Percent Patient Share in Europe in Newly Diagnosed Glioblastoma Multiforme, According to a New Report from Decision Resources

WALTHAM, Mass., March 9 /PRNewswire/ -- Decision Resources, one of the world's leading research and advisory firms for pharmaceutical and healthcare issues, finds that surveyed oncologists identify a therapy's effect on overall survival as the attribute that most influences their prescribing decisions in high-grade glioma. Clinical data and the opinions of interviewed thought leaders indicate that Roche/Genentech/Chugai's Avastin has advantages in this attribute over Schering-Plough's Temodar/Temodal (temozolomide), the sales-leading agent in the market.

The new report entitled High-Grade Glioma: Prolonged Survival over Temozolomide Will Be Integral to Market Success finds that a therapy, when added to temozolomide, that increases median overall survival compared with temozolomide alone would earn a 65 percent patient share in the United States and a 30 percent share in Europe in newly diagnosed glioblastoma multiforme, according to surveyed U.S. and European oncologists.

In 2008, Decision Resources' proprietary clinical gold standard for high-grade glioma was Avastin. Although Avastin is not formally approved for the treatment of high-grade glioma, the drug is widely prescribed off-label as a result of promising Phase II clinical trial data. Based on expert opinion, Avastin will retain clinical gold standard status through 2017, owing to its high efficacy.

"Avastin emerges as our gold standard because of its efficacy, the attribute surveyed oncologists rated as the most important in treating high-grade glioma," said Decision Resources Analyst Ramya Kollipara, Ph.D. "Because the prognosis for high-grade glioma patients is so poor, inter
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SOURCE Decision Resources
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