Navigation Links
Surprising new insights into the PTEN tumor suppressor gene
Date:4/24/2014

BOSTON Ever since it was first identified more than 15 years ago, the PTEN gene has been known to play an integral role in preventing the onset and progression of numerous cancers. Consequently, when PTEN is either lost or mutated, malignant cells can grow unchecked and cancer can develop.

Now a team led by investigators at Beth Israel Deaconess Medical Center (BIDMC) helps explain more precisely how PTEN exerts its anti-cancer effects and how its loss or alteration can set cells on a cancerous course. The new study, which reveals that PTEN loss and PTEN mutations are not synonymous, not only provides key insights into basic tumor biology but also offers a potential new direction in the pursuit of new cancer therapies.

The findings are reported online in the April 24 issue of the journal Cell.

"By characterizing the ways that two specific PTEN mutations regulate the tumor suppressor function of the normal PTEN protein, our findings suggest that different PTEN mutations contribute to tumorigenesis by regulating different aspects of PTEN biology," explains senior author Pier Paolo Pandolfi, MD, PhD, Director of the Cancer Center at BIDMC and George C. Reisman Professor of Medicine at Harvard Medical School. "It has been suggested that cancer patients harboring mutations in PTEN had poorer outcomes than cancer patients with PTEN loss. Now, using mouse modeling, we are able to demonstrate that this is indeed the case. Because PTEN mutations are extremely frequent in various types of tumors, this discovery could help pave the way for a new level of personalized cancer treatment."

The PTEN gene encodes a protein, which acts as a phosphatase, an enzyme that removes phosphates from other substrates. Several of the proteins that PTEN acts upon, both lipids and proteins, are known to promote cancer when bound to a phosphate. Consequently, when PTEN removes their phosphates, it is acting as a tumor suppressor to prevent cancer
'/>"/>

Contact: Bonnie Prescott
bprescot@bidmc.harvard.edu
617-667-7306
Beth Israel Deaconess Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Surprising results for use of dialysis for kidney failure in developing world
2. NYC Doc Announces 3 Surprising Ways to Beat Seasonal Allergies
3. Generation X is surprisingly unconcerned about climate change
4. Comparison of Obesity Surgeries Turns Up Surprising Results
5. Surprising findings from NHLBI Exome Sequencing Project reported
6. First study of Oregons Hmong reveals surprising influences on cancer screenings
7. Surprising connections between our well-being and giving, getting, and gratitude
8. Defective virus surprisingly plays major role in spread of disease, UCLA life scientists report
9. Tornado Survivors Surprisingly Optimistic, Study Finds
10. Surprising rate of women depressed after baby
11. Hair Loss Reveals Surprising Heart Attack Risks in Men, Study Finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... News) -- Pigs, hearts transplanted into baboons survived for ... as previously achieved, researchers report. The work is ... organs to shorten transplant waiting lists. In this ... baboons, abdomens. The genetic engineering and new methods of ... the hearts to survive for more than a year. ...
(Date:8/20/2014)... Reinberg HealthDay Reporter WEDNESDAY, ... cancer cells grow may help doctors diagnose and treat the ... investigators have found that the deadliest skin cancers occur most ... a long history of sun exposure. These lesions also ... Rapid cell growth -- called "high mitotic rate" -- ...
(Date:8/20/2014)... persistent and deadliest infectious diseases in the world, killing ... who study tuberculosis have long debated its origins. New ... Africa to seals and sea lions that brought the ... people there before Europeans landed on the continent. , ... Source of New World Human Tuberculosis," was published in ...
(Date:8/20/2014)... New York, New York (PRWEB) August 20, 2014 ... associated with the use of power morcellators ( http://www.injurybeacon.com/power-morcellator/ ... Liebhard LLP notes that two U.S. Senators from New ... (FDA) to seek a recall of the devices. In ... Charles Schumer, both Democrats, also implored the agency to ...
(Date:8/20/2014)... contrast to evidence that the amygdala stimulates stress ... Research Center, Emory University have found that the ... during the early development of nonhuman primates. , ... Journal of Neuroscience . , The amygdala is ... important for responses to threatening situations and learning ...
Breaking Medicine News(10 mins):Health News:Pigs' Hearts Beat for a Year in Baboons' Abdomens 2Health News:High-Risk Melanomas Often on Head or Neck, Study Finds 2Health News:High-Risk Melanomas Often on Head or Neck, Study Finds 3Health News:New research shows seals and sea lions likely spread tuberculosis to humans 2Health News:New research shows seals and sea lions likely spread tuberculosis to humans 3Health News:Power Morcellator News: Bernstein Liebhard LLP Notes Senators’ Letter Seeking FDA Morcellator Recall 2Health News:Power Morcellator News: Bernstein Liebhard LLP Notes Senators’ Letter Seeking FDA Morcellator Recall 3Health News:Power Morcellator News: Bernstein Liebhard LLP Notes Senators’ Letter Seeking FDA Morcellator Recall 4Health News:Maturing brain flips function of amygdala in regulating stress hormones 2Health News:Maturing brain flips function of amygdala in regulating stress hormones 3
... Red Compounds Financial Problems, According ... July 14 HealthLeaders-InterStudy, a,leading provider of healthcare ... the hospitals in the Los Angeles market are ... doing relatively well financially,and those that are barely ...
... and Blue Shield companies to,promote workplace wellness programs ... Recognizing that chronic,illness accounts for 75 percent ... on" approach to improving employee health and wellness ... prevention,and management. At a press briefing this morning ...
... of Health,and Hospitals announced its intent to award HMS ... and cost avoidance services,to the state,s Medicaid program. This ... the highest score in a competitive procurement process,for the ... the state, HMS recovered more than,$36 million for the ...
... Zimmer Holdings, Inc.,(NYSE: ZMH ; SWX: ZMH) statement:, ... that Zimmer,s,NexGen(R) knee implant had been recalled. In fact, ... used for minimally invasive,surgeries (MIS) and not the implant ... to a single surgical instrument and that additional,instrumentation options ...
... Bring Better Quality of Care and Improved Business Performance ... ... PITTSBURGH, July 14 Vocollect Healthcare Systems, Inc.,and SouthMed, Inc., ... healthcare market, announce a,strategic partnership, whereby SouthMed will resell AccuNurse,voice-assisted care ...
... Optimism is good for heart health, at least among ... Medical Center researcher Robert Gramling, M.D., D.Sc., found that ... cardiovascular disease actually experienced a three times lower incidence ... data did not support the same conclusion among women. ...
Cached Medicine News:Health News:Fragmented Los Angeles Hospital Market Provides Health Systems with Little Leverage to Negotiate Higher Reimbursement 2Health News:Employers Take Active Role in Promoting Workplace Wellness 2Health News:Employers Take Active Role in Promoting Workplace Wellness 3Health News:Louisiana Department of Health and Hospitals Announces Intent to Award Cost Containment Services Contract to HMS 2Health News:Zimmer Holdings Issues Clarification Regarding NexGen Knee System 2Health News:Zimmer Holdings Issues Clarification Regarding NexGen Knee System 3Health News:SouthMed, Inc. and Vocollect Healthcare Systems Announce Reseller Agreement 2Health News:Positive thinking is prescription for the heart 2
(Date:8/20/2014)... Aug. 20, 2014 Reportlinker.com announces that ... its catalogue: Global Coatings for Medical ... This report analyzes the worldwide ... Million by the following Product Segments: Active Coatings, ... report provides separate comprehensive analytics for the US, ...
(Date:8/20/2014)... 20, 2014 ApolloDx™ today announced it will ... a special event at the company,s office in ... 5, 2014. The event, which will start at 10:00 ... www.apollodx.com .    "We believe our ... Jared Bauer , Co-Founder and Managing Partner of ApolloDx. ...
(Date:8/20/2014)... Aug. 20, 2014   Easy Breathe , the fastest growing ... " Easy Blog " - has received more than 4.5 million ... "We are thrilled that so many people are finding our ... of Easy Breathe. "We,re committed to making sleep apnea more widely ... stay informed about sleep apnea news , troubleshooting advice ...
Breaking Medicine Technology:Global Coatings for Medical Devices Industry 2Global Coatings for Medical Devices Industry 3Global Coatings for Medical Devices Industry 4Global Coatings for Medical Devices Industry 5Global Coatings for Medical Devices Industry 6Global Coatings for Medical Devices Industry 7Global Coatings for Medical Devices Industry 8Global Coatings for Medical Devices Industry 9Global Coatings for Medical Devices Industry 10Global Coatings for Medical Devices Industry 11Global Coatings for Medical Devices Industry 12Global Coatings for Medical Devices Industry 13Global Coatings for Medical Devices Industry 14Global Coatings for Medical Devices Industry 15Global Coatings for Medical Devices Industry 16Global Coatings for Medical Devices Industry 17Global Coatings for Medical Devices Industry 18Global Coatings for Medical Devices Industry 19Global Coatings for Medical Devices Industry 20Global Coatings for Medical Devices Industry 21Easy Breathe Blog Emerges as the Go-To Resource for Sleep Apnea Sufferers 2Easy Breathe Blog Emerges as the Go-To Resource for Sleep Apnea Sufferers 3Easy Breathe Blog Emerges as the Go-To Resource for Sleep Apnea Sufferers 4
An enzyme-linked immuno-sorbent assay for the detectionand quantitation of anti-tissue Transglutaminase in serum of patients with Celiac Disease and Dermatitis Herpetiformis....
Jerome Halo Traction Units provide optimum immobilization for unstable injuries of the spine. The Generation 80 superstructure is available with either 2-point (serrated disk), or 3-point (flexion/ex...
... Boston Scoliosis Brace™ for neuromuscular ... a lightweight, soft, and easy ... maximum comfort. The Soft ... of non-cracking orthopedic grade copolymer ...
An indirect immunofluorescence antibody test for the qualitative and semi-quantitative detection of endomysial antibodies (EMA) in human serum as an aid in the diagnosis of celiac disease and dermati...
Medicine Products: