Navigation Links
Surprise in Lab Helps ID Drug to Fight ALS
Date:1/24/2008

Study shows apocynin almost doubles life span of mice with inherited Lou Gehrig's disease

THURSDAY, Jan. 24 (HealthDay News) -- A drug that nearly doubles the life span of mice with inherited amyotrophic lateral sclerosis (ALS) has been identified by University of Iowa researchers, who made the finding after discovering an unexpected reaction between proteins in the lab.

The study results, published online Jan. 24 in The Journal of Clinical Investigation, may lead to treatments for some forms of ALS (also known as Lou Gehrig's disease), a fatal neurodegenerative disease that destroys motor nerve cells in the brain and spinal cord.

The researchers were studying the basic biology of cell signaling when they made the unexpected discovery that superoxide dismutase-1 (SOD1) -- a protein that's mutated in inherited forms of ALS -- interacts with Rac1, a protein that regulates production of reaction oxygen species (ROS) by the Nox2 protein complex.

ROS is essential for normal cell function, but abnormal ROS production is a suspected cause of ALS and other neurodegenerative diseases.

This unexpected interaction prompted the researchers to take a closer look.

They first found that deletion of the Nox2 protein almost doubled the life span of mice with inherited ALS. This provided further evidence that Nox-2 generated ROS may play a role in ALS progression. The researchers then found that a drug called apocynin, which blocks Nox2, slows ALS progression and increases life span of mice with inherited ALS.

About 5 percent to 10 percent of ALS cases in the United States are inherited, while 90 percent to 95 percent of ALS cases are not inherited and can affect anyone.

There are no mouse models for sporadic ALS, so the researchers were unable to test whether apocynin has any effect on sporadic ALS. The researchers also noted that extensive safety and efficacy testing in pre-clinical trials must be conducted to determine if apocynin is effective in people.

The discovery of the interaction between SOD1 and Rac1 may prove to have widespread importance.

"It is exciting not only from the standpoint of ALS, but also because of its implications for understanding basic cell biology. Rac1 is implicated in many cellular processes including cellular migration, proliferation and differentiation, and is an important component of inflammatory disease processes," team leader John Engelhardt, head of anatomy and cell biology at UI's Roy J. and Lucille A. Carver College of Medicine, said in a prepared statement.

More information

The Muscular Dystrophy Association has more about ALS.



-- Robert Preidt



SOURCE: University of Iowa, news release, Jan. 24, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Putting on Pedometer Helps Walkers Shed Pounds
2. Hormone Therapy Only Helps Some Older Men With Prostate Cancer
3. Saline Nasal Wash Helps Kids Fight Colds, Flu
4. Delta Dental Financial Support Helps ODA Members Serve Children in Need
5. Increased Usage of Mifeprex(R) Helps Slow Decline in Abortion Providers
6. Consuming extra virgin olive oil helps to combat degenerative diseases such as cancer
7. Philadelphia Policeman Helps Amputee Receive Power Wheelchair from The Scooter Store
8. Philadelphia Police Officer Helps Amputee Receive Power Wheelchair From The SCOOTER Store
9. Dual Treatment Helps Wean Patients From Ventilators
10. Statin Therapy Helps Diabetic Patients
11. Jefferson scientists find protein helps pancreatic cancer cells evade immune system and spread
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/30/2016)... ... April 30, 2016 , ... Orlando-based Maximized Living has ... go for gold in Rio. Under the care of Maximized Living doctors at ... In an unprecedented showing, Maximized Living is sending the largest contingent of elite chiropractors ...
(Date:4/29/2016)... ... April 29, 2016 , ... Memorial ... for Graduate Medical Education (ACGME) that it has received accreditation for its residency ... of three residency programs that Memorial is currently pursuing, including Pediatrics and Internal ...
(Date:4/29/2016)... ... April 29, 2016 , ... Dr. Bernie Siegel, ... "LOVE, MEDICINE and MIRACLES") addresses touchy topics related to Death live on ... Dr. Bernie Siegel, author of a plethora of essential books-to-read for physicians ...
(Date:4/29/2016)... ... ... Spine Team Texas, a comprehensive spine physician group specializing in the treatment of ... invited to be a featured speaker at the Texas Society of the American College ... , Dr. R. Scott McPherson, a physical medicine and rehabilitation specialist, will speak ...
(Date:4/29/2016)... ... ... the deadliest type of skin cancer. Although only about 1 percent of skin cancer cases ... 10,000 people are expected to die of melanoma this year. The risk increases with age, ... most commonly diagnosed cancers in young women. A recent breakthrough in genetic studies may give ...
Breaking Medicine News(10 mins):
(Date:4/29/2016)... April 29, 2016 Glycotope GmbH, ... today announces the appointment of Dr. Alfredo Zurlo ... is an oncologist with many years clinical experience and ... industries. His last role was at Mologen AG where ... Executive Board. Previously Dr. Zurlo held various positions at ...
(Date:4/28/2016)...  While Abbott,s announced purchase of St. Jude ... and stent business, healthcare research firm Kalorama Information ... into patient monitoring.  Kalorama said that patient monitoring ... with double-digit growth expected the next 5 years, ... Patient Monitoring . Abbott Laboratories agreed to ...
(Date:4/28/2016)... 2016 Dr. ... und Stephen Schmidt werden ... ArisGlobal®, ein führender Anbieter cloudbasierter Softwarelösungen für ... dass neue Führungskräfte zum Team Sicherheit und ... vielfältige Erfahrungen mitbringen.  Dies wird die Geschäftseinheit ...
Breaking Medicine Technology: