Navigation Links
Surprise finding: Pancreatic cancers progress to lethal stage slowly
Date:10/27/2010

ad to other organs. Patients die an average of two and a half years after this metastasis.

The results contradict the idea that pancreatic cancers metastasize very early in their development, says Iacobuzio-Donahue.

For the study, scientists collected tissue samples during autopsies of seven patients who died from pancreatic cancer that had metastasized to other organs. Because the tissue samples were taken within six hours of each patient's death, the scientists were able to keep some of the cells alive long enough to extract the DNA and sequence the series of chemical "letters" that form genes.

In all patients, metastatic deposits were found in two or more sites in the body, most often the liver, lung and peritoneum (lining of the abdomen). The researchers found similar mutations present in both the areas of metastasis and in the primary pancreatic tumors from which the metastases arose.

They also identified and classified the types of mutations ones that occur before metastasis and others that happen after the cancer has spread. Both types of mutations were present within the primary tumor years before the metastases became clinically evident, according to Iacobuzio-Donahue.

Using mathematical models to study the timing of pancreatic cancer progression, the scientists conservatively estimated an average of 11.7 years before the first cancer cell develops within a high-grade pancreatic lesion, then an average of 6.8 years as the cancer grows and at least one cell has the potential to spread, and finally, an average of 2.7 years from then until a patient's death.

The Hopkins scientists say the goal is develop a pancreatic cancer screening method similar to the protocol used for breast and colon cancer. Though early stages of pancreatic cancer cause no symptoms, Iacobuzio-Donahue says, perhaps at a certain age people should undergo an endoscopy to screen for pancreatic cancer. Endoscopy is a procedure allowing
'/>"/>

Contact: Vanessa Wasta
wastava@jhmi.edu
410-955-1287
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. SIDS surprise: Study finds that infant boys are more easily aroused from sleep than girls
2. Health: Surprise Best Seller is Stem Cell Book – Author in Spokane - 10 City Tour
3. Revising the timeline for deadly pancreatic cancer
4. Rice, TMC team take aim at pancreatic cancer
5. UNC scientists receive grant to develop nanotechnology for pancreatic cancer diagnosis and treatment
6. Protein key to growth of pancreatic cancer
7. New investigational compound targets pancreatic cancer cells
8. Endoscopic ultrasound evaluation is associated with improved outcomes in pancreatic cancer patients
9. New combination effective against pancreatic cancer
10. Cysts hold clues to pancreatic cancer
11. Targeted immunotherapy shows promise for metastatic breast, pancreatic cancers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... The federal court overseeing thousands of vaginal ... Southern District of West Virginia has upheld a $2 million ... bellwether trial. In an Order dated January 21st, the Court ... that C.R. Bard had not proven a miscarriage of justice. ...
(Date:1/22/2015)... New York, New York (PRWEB) January 22, 2015 ... filed after Fresenius Medical Care recalled its GranuFlo ... the federal multidistrict litigation underway in U.S. District Court, ... an Order dated January 20th, the Court has remanded ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Carinsurancesavings.biz has released ... accidental death and dismemberment insurance . , Purchasing an ... can be very advantageous. This type of rider provides benefits ... dismemberment can be considered a lesser form of life insurance. ...
(Date:1/22/2015)... 2015 Yesterday, Senator Holly Mitchell ... Kristin Olsen (R-Modesto) were honored by the California ... biotechnology, biomedical science, medical device and pharmaceutical innovation ... the “2014 Life Sciences Champion” award from CHI ...
(Date:1/22/2015)... years since the release of their debut recording Love is King, ... & Matthew Love – the duo are pleased to announce their ... Swan Records on February 24, 2015. , THE ROAD offers the ... all of us to walk out of the mire of our ...
Breaking Medicine News(10 mins):Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 2Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 3Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 4Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 2Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 3Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 4Health News:Accidental Death and Dismemberment Insurance Can Be Purchased at Low Prices Online 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 3Health News:THE ROAD by Avasa & Matthew Love -- A New Album 2Health News:THE ROAD by Avasa & Matthew Love -- A New Album 3Health News:THE ROAD by Avasa & Matthew Love -- A New Album 4
... addiction has reached alarming proportions, with the number of ... such as heroin or cocaine//. Health authorities from the ... taken to change the trend, it could lead to ... as it is commonly known, is a stimulant that ...
... Adolescents involved in sports activities seem to eat healthy ... a new study has found//. ,Teenage girls ... gymnastics and wrestling are more likely to eat breakfast ... compared to other girls who were not involved in ...
... million American adults are smokers, obese or both and are faced ... // ,Data from a 2002 national health interview ... United States who have one or both problems. ,The ... million people and this would include a larger percentage of them ...
... the medical students in Scotland to voice their opinion against ... the Scottish Parliament to show their disapproval. The students said ... close to the top-up fees. But ministers and Scottish Executive ... , But last year the Scottish ministers passed the Further ...
... to a recent study conducted by the researchers at New ... in seven East Asian immigrants are carriers// of the hepatitis ... cancer and cirrhosis. But it is surprising to know that ... Three-quarters of these people who are infected had no health ...
... hit by a rubella epidemic, with more than 6000 people ... worst affected//, said a Government health official. ,‘The ... 6,000,’ said Pham Ngoc Dinh, deputy director of the National ... largest outbreaks has been in Ho Chi Minh City's manufacturing ...
Cached Medicine News:Health News:Meth Addiction On The Rise, US Health Authorities Concerned 2Health News:East Asian Immigrants Bring Hepatitis to New York 2
(Date:1/23/2015)... DUBLIN , Jan. 23, 2015  Immune Therapeutics, Inc. ... Biotechnology, Inc. for the compounding, packaging and distributing of its ... the United States . ... of compounding naltrexone tablets in various strengths for individual patients ...
(Date:1/23/2015)... 23, 2015  iMD Companies, Inc. (ICBU) has repositioned itself as ... and grab a foothold in the hydroponic, hemp and medical ... a presence in the sector, and recently partnering with the ... hemp and medical marijuana, iMD is committing to bring its ...
(Date:1/23/2015)... 23, 2015  Mallinckrodt plc (NYSE: MNK ) ... a share repurchase program. The open-ended authorization permits the ... plc ordinary shares. "Funding additional initiatives ... as we continue to pursue a range of focused ...
Breaking Medicine Technology:Immune Therapeutics, Inc. Announces Agreement with KRS Global Biotechnology, Inc. 2Immune Therapeutics, Inc. Announces Agreement with KRS Global Biotechnology, Inc. 3Immune Therapeutics, Inc. Announces Agreement with KRS Global Biotechnology, Inc. 4iMD Companies Poised to Make Impact in Multi-Billion Dollar Medical Marijuana Sector With Recent Investments and Strategic Partnerships 2Mallinckrodt plc Announces Share Repurchase Program 2Mallinckrodt plc Announces Share Repurchase Program 3Mallinckrodt plc Announces Share Repurchase Program 4
... 2012 Star Scientific, Inc. (NASDAQ: CIGX ... Inc., announces that it has received important new research ... Sarasota, Florida. The Institute has completed a successful animal ... anatabine (patent pending), in an animal model of multiple ...
... PDII ) today announced that it will release its ... after the market close and host a conference call on ... the results.Access information:Date: , Tuesday, May 15, 2012Time:  , ... and Canada) or (706) 643-1203Conference ID number: , 72367450Live web ...
Cached Medicine Technology:Roskamp Institute Reports Beneficial Effects of Nutritional Supplementation with Anatabine in an Animal Model of Multiple Sclerosis 2Roskamp Institute Reports Beneficial Effects of Nutritional Supplementation with Anatabine in an Animal Model of Multiple Sclerosis 3Roskamp Institute Reports Beneficial Effects of Nutritional Supplementation with Anatabine in an Animal Model of Multiple Sclerosis 4
... Tecan Haemotyper is an automated ... The Tecan Haemotyper combines a ... platform with the DiaMed agglutination ... process DiaMed-ID cards and microplates ...
... people are in need of MRI exams, ... tunnel-type scanners. They have heard of, or ... claustrophobic and noisy tubes of supercon scanners ... What people want is a patient-friendly MRI. ...
Picofluor™ Fluorometer is a lightweight, inexpensive, handheld fluorometer, configured for the fluorescent probes commonly used for nucleic acid and protein quantitation....
... a spectro-fluorometer supplied by HORIBA ... a new type of spectro-fluorometer ... various components. The flexible system ... choose components that best suit ...
Medicine Products: