Navigation Links
Surprise finding: Pancreatic cancers progress to lethal stage slowly
Date:10/27/2010

ad to other organs. Patients die an average of two and a half years after this metastasis.

The results contradict the idea that pancreatic cancers metastasize very early in their development, says Iacobuzio-Donahue.

For the study, scientists collected tissue samples during autopsies of seven patients who died from pancreatic cancer that had metastasized to other organs. Because the tissue samples were taken within six hours of each patient's death, the scientists were able to keep some of the cells alive long enough to extract the DNA and sequence the series of chemical "letters" that form genes.

In all patients, metastatic deposits were found in two or more sites in the body, most often the liver, lung and peritoneum (lining of the abdomen). The researchers found similar mutations present in both the areas of metastasis and in the primary pancreatic tumors from which the metastases arose.

They also identified and classified the types of mutations ones that occur before metastasis and others that happen after the cancer has spread. Both types of mutations were present within the primary tumor years before the metastases became clinically evident, according to Iacobuzio-Donahue.

Using mathematical models to study the timing of pancreatic cancer progression, the scientists conservatively estimated an average of 11.7 years before the first cancer cell develops within a high-grade pancreatic lesion, then an average of 6.8 years as the cancer grows and at least one cell has the potential to spread, and finally, an average of 2.7 years from then until a patient's death.

The Hopkins scientists say the goal is develop a pancreatic cancer screening method similar to the protocol used for breast and colon cancer. Though early stages of pancreatic cancer cause no symptoms, Iacobuzio-Donahue says, perhaps at a certain age people should undergo an endoscopy to screen for pancreatic cancer. Endoscopy is a procedure allowing
'/>"/>

Contact: Vanessa Wasta
wastava@jhmi.edu
410-955-1287
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. SIDS surprise: Study finds that infant boys are more easily aroused from sleep than girls
2. Health: Surprise Best Seller is Stem Cell Book – Author in Spokane - 10 City Tour
3. Revising the timeline for deadly pancreatic cancer
4. Rice, TMC team take aim at pancreatic cancer
5. UNC scientists receive grant to develop nanotechnology for pancreatic cancer diagnosis and treatment
6. Protein key to growth of pancreatic cancer
7. New investigational compound targets pancreatic cancer cells
8. Endoscopic ultrasound evaluation is associated with improved outcomes in pancreatic cancer patients
9. New combination effective against pancreatic cancer
10. Cysts hold clues to pancreatic cancer
11. Targeted immunotherapy shows promise for metastatic breast, pancreatic cancers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/20/2014)... LunaDress has recently announced its 2015 collection of ... on all of its special occasion dresses & wedding apparel. ... wedding gown. If you have no idea of what to ... different wedding dress styles and our dress experts are here ... current special offer, up to 80% off," the CEO of ...
(Date:12/20/2014)... holidays can be anything but joyous for people with ... and other allergy triggers. "The dust from the ... away in dank basements or dusty attics is triggering ... Shah, an affiliate faculty member at Loyola University Chicago ... Shah, who is also an allergist at Gottlieb ...
(Date:12/20/2014)... Angeldress.co.uk, the distinguished wedding dress manufacturer and retailer, has ... company has recently updated its official blog with the ... Angeldress Blog has recommended some new designs ... itself in offering a huge selection of elegant products ... outfits are very carefully selected based on the design ...
(Date:12/20/2014)... 2014 The aftermath of the November 24th ... not only in Hollywood, but worldwide. As reported ... ripples of that attack are starting a finger-pointing game which ... But they are not the only ones affected, regular ... for some embarrassing times ahead, agents and lawyers could be ...
(Date:12/20/2014)... Xarelto bleeding lawsuits filed by men ... and other serious side effects will be consolidated in ... coordinated pretrial proceedings, Wright & Schulte LLC reports. The ... order Friday to transfer 21 Xarelto lawsuits and over ... to the Louisiana district court for coordination by Judge ...
Breaking Medicine News(10 mins):Health News:2015 Collection of Wedding Dresses from LunaDress Online on Sale Now 2Health News:Holiday Trimmings Can Trigger Allergies 2Health News:Trendy Professional Wedding Apparel Recommended by Angeldress Blog 2Health News:Sony Pictures Hack Perfect Example of the Reach a Single Cyber Attack Can Have 2Health News:Sony Pictures Hack Perfect Example of the Reach a Single Cyber Attack Can Have 3Health News:Sony Pictures Hack Perfect Example of the Reach a Single Cyber Attack Can Have 4Health News:Sony Pictures Hack Perfect Example of the Reach a Single Cyber Attack Can Have 5Health News:Xarelto Bleeding Lawsuits Consolidated To Louisiana Federal Court For Multi-District Litigation Reports Wright & Schulte LLC 2Health News:Xarelto Bleeding Lawsuits Consolidated To Louisiana Federal Court For Multi-District Litigation Reports Wright & Schulte LLC 3Health News:Xarelto Bleeding Lawsuits Consolidated To Louisiana Federal Court For Multi-District Litigation Reports Wright & Schulte LLC 4
... 2009 - In a study by Miall, Gowen and Tchalenko ... ( http://www.elsevier.com/locate/cortex ), a brain scanner was used to ... of drawing faces. The researchers found that the captured visual ... plans to reach those locations. It is as if the ...
... April 1-5, 2009 at Marriott Wardman Park ... Osteoporosis Foundation (NOF) will bring together a ... relevant evidence-based information on bone health and ... of healthcare professionals at its comprehensive annual ...
... the Nebraska Medical AssociationOMAHA, Neb., March 19 With ... three months, it,s time for those who smoke to ... so on Wednesday, March 25, when school children throughout ... sponsored by the Campaign for Tobacco Free Kids. ...
... Increasing Sales of the Company,s Innovative Revenue Cycle ... charge capture technologies, today announced that it has ... led by existing investor Boston Millennia Partners. This ... growth of its Intelligent Charge Capture suite of ...
... Eating out, lack of social support and high-risk lifestyles ... with type 2 diabetes from controlling their condition, according ... 4,550 healthcare providers from 28 countries. , The ... Journal of Nursing and Healthcare of Chronic Illness , ...
... Field Museum for World Water Day March 22 CHICAGO, ... product safety testing services, will launch its water quality and ... Museum, 1400 S. Lake Shore Drive in Chicago, from 10:00 ... As part of the organization,s century-long commitment to public health ...
Cached Medicine News:Health News:The brain 'joins the dots' when drawing a cartoon face from memory 2Health News:Latest Osteoporosis Research Translated for Health Professionals to Use in Clinical Setting 2Health News:Kick Butts Day a Timely Prelude to Nebraska's June 1 Smoking Ban 2Health News:MedAptus Secures $6 Million Investment 2Health News:Barriers to diabetes care include restaurants and high-risk lifestyles, says international review 2Health News:Barriers to diabetes care include restaurants and high-risk lifestyles, says international review 3Health News:World Water Day 2009 Marks Launch of UL's Yearlong Commitment to Water Quality and Conservation Education 2Health News:World Water Day 2009 Marks Launch of UL's Yearlong Commitment to Water Quality and Conservation Education 3
(Date:12/19/2014)... , Dec. 18, 2014 Somewhere between ... hearing health was forgotten. But Audicus , a ... hear better this new year. Hearing loss ... the aging population, though it is often unaddressed. Forty-eight ... four has a hearing aid, mainly due to price. ...
(Date:12/19/2014)... CITY, Calif., Dec. 18, 2014 Capnia, ... the development of medical diagnostics based on its ... gas flow, today announced financial results for the ... 2014. "Following the completion of our ... positioned to maximize the recently initiated CoSense® commercial ...
(Date:12/19/2014)... , Dec. 18, 2014   Aratana Therapeutics, ... biopharmaceutical company focused on the licensing, development and ... announced positive results from its pivotal field study ... treating pain in dogs with osteoarthritis.  In the ... assessment scores that were statistically significant compared to ...
Breaking Medicine Technology:Audicus Will Help People Resolve to Hear Better in 2015 2Capnia Reports Third Quarter 2014 Financial Results 2Capnia Reports Third Quarter 2014 Financial Results 3Capnia Reports Third Quarter 2014 Financial Results 4Capnia Reports Third Quarter 2014 Financial Results 5Capnia Reports Third Quarter 2014 Financial Results 6Capnia Reports Third Quarter 2014 Financial Results 7Capnia Reports Third Quarter 2014 Financial Results 8Aratana Therapeutics Announces Positive Top-Line Results from AT-001 Pivotal Field Study in Client-Owned Dogs with Osteoarthritis 2Aratana Therapeutics Announces Positive Top-Line Results from AT-001 Pivotal Field Study in Client-Owned Dogs with Osteoarthritis 3Aratana Therapeutics Announces Positive Top-Line Results from AT-001 Pivotal Field Study in Client-Owned Dogs with Osteoarthritis 4Aratana Therapeutics Announces Positive Top-Line Results from AT-001 Pivotal Field Study in Client-Owned Dogs with Osteoarthritis 5
... , , , ... majority-owned subsidiary of Speedus Corp. (Nasdaq: SPDE ), ... the U.S. FDA, has cleared the Zargis Cardioscan(TM) device ... analysis software connects wirelessly to a Bluetooth®-enabled electronic stethoscope ...
... NATICK, Mass., Jan. 8 Boston Scientific Corporation (NYSE: ... from the Japanese Ministry of Health, Labor and Welfare (MHLW) ... treatment of coronary artery disease. The Company plans to ... which is expected in the coming weeks. , The PROMUS ...
Cached Medicine Technology:Zargis Cardioscan Cleared for Sale in Canada 2Zargis Cardioscan Cleared for Sale in Canada 3Boston Scientific Announces Japanese Approval for PROMUS(R) Everolimus-Eluting Coronary Stent System 2Boston Scientific Announces Japanese Approval for PROMUS(R) Everolimus-Eluting Coronary Stent System 3Boston Scientific Announces Japanese Approval for PROMUS(R) Everolimus-Eluting Coronary Stent System 4
... nebulizer system offers an affordable and ... COPD or other respiratory conditions. The ... gives patients the ability to take ... Its unique nebulizer design delivers powerful ...
Pediatric Compressor Nubulizer...
... very popular and competitively priced SportNeb ... compressor. Design enhancements include a neb ... optional black carry bag. The color ... The SportNeb also offers private labeling ...
... is an important part of managing the ... convenient products mean delivering the aerosolized medication ... while minimizing medication waste. Aerosol delivery with ... of Nebulizers, including the new NebuTech® HDN®, ...
Medicine Products: