Surgical technique halts cell loss, Parkinson's resear... (l's research was a response to an observ...)

Surgical technique halts cell loss, Parkinson's researchers find

Date:9/2/2008

l's research was a response to an observation by physicians, including co-investigator George Mandybur, M.D., associate professor of neurosurgery, who have long been able to neutralize, in certain patients, some of the most debilitating symptoms of Parkinson's disease, including tremor, stiffness, and slowness, by stimulating an area deep within the brain.

"The surgery for Parkinson's disease has been available for over 10 years, and in that time we have noticed that in some patients the disease does not seem to progress as rapidly after surgery as it did before the surgery," says Mandybur, a neurosurgeon with the Mayfield Clinic. As a result, he and others theorized that DBS not only alleviated symptoms, but also provided neuroprotection.

The UC study, Mandybur says, "helps us to understand why this is going on and what may be happening in the brain. It also gives some evidence to support performing the surgery earlier to slow the overall progression of Parkinson's disease."

Sortwell's study, which is continuing, is supported by a $120,000 grant from the Sunflower Revolution fundraiser, a partnership of the University Hospital Foundation and the Davis Phinney Foundation. The 2008 Sunflower Revolution, scheduled for Sept. 5-7, includes a gala, a free educational symposium for patients, families and caregivers, and bike rides of 20, 40, and 100 kilometers. (See www.sunflowerrev.org.)

During the DBS study, researchers implanted high-frequency stimulating electrodes in the subthalamic nucleus, an area of the brain associated with movement, in rats and then induced dopamine neuron loss. When the rats had experienced a 50 percent loss of dopamine neurons, the researchers initiated brain stimulation in half of the group. Measurements of surviving, functioning dopamine neurons in rats implanted with active stimulators were then compared to a control group implanted with inactive stimulators.
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Contact: Cindy Starr
cstarr@mayfieldclinic.com
513-569-5321
University of Cincinnati
Source:Eurekalert

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Surgical technique halts cell loss, Parkinson's resear...(l's research was a response to an observ...),Health